KWMTBOMO05081

Protein

Length

2,014 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
622 - 872
Peptidase S1, PA clan (IPR009003)
Serine proteases, trypsin domain (IPR001254)
1,359 - 1,427
SRCR-like domain (IPR017448)
SRCR domain (IPR001190)
1,517 - 1,841
Peptidase S1, PA clan (IPR009003)
Serine proteases, trypsin domain (IPR001254)
Peptidase S1A, nudel (IPR015420)
1,904 - 1,949
SRCR domain (IPR001190)
Repeat
347 - 386
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
385 - 417
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
413 - 456
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
882 - 920
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
1,253 - 1,321
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
1,322 - 1,360
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
1,739 - 1,776
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
1,791 - 1,831
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
1,833 - 1,854
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
1,860 - 1,903
Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)

1 200 400 600 800 1000 1200 1400 1600 1800 2014

Detailed signature matches

IPR009003

Peptidase S1, PA clan
1. SSF50494 (Trypsin-l...)
  
  1,517 - 1,715
  
  SUPERFAMILY
  SSF50494 (Trypsin-like serine proteases)
  
  622 - 872
  
  SUPERFAMILY
  SSF50494 (Trypsin-like serine proteases)
IPR001254

Serine proteases, trypsin domain
1. SM00020 (trypsin_2)
  
  634 - 866
  
  SMART
  SM00020 (trypsin_2)
2. PS50240 (TRYPSIN_DOM)
  
  1,521 - 1,841
  
  PROSITE profiles
  PS50240 (TRYPSIN_DOM)
  
  635 - 871
  
  PROSITE profiles
  PS50240 (TRYPSIN_DOM)
3. PF00089 (Trypsin)
  
  635 - 866
  
  Pfam
  PF00089 (Trypsin)
4. cd00190 (Tryp_SPc)
  
  635 - 869
  
  CDD
  cd00190 (Tryp_SPc)
IPR017448

SRCR-like domain
1. SSF56487 (SRCR-like)
  
  1,378 - 1,427
  
  SUPERFAMILY
  SSF56487 (SRCR-like)
IPR001190

SRCR domain
1. PS50287 (SRCR_2)
  
  1,359 - 1,420
  
  PROSITE profiles
  PS50287 (SRCR_2)
  
  1,904 - 1,949
  
  PROSITE profiles
  PS50287 (SRCR_2)
IPR015420

Peptidase S1A, nudel
1. PF09342 (DUF1986)
  
  1,522 - 1,636
  
  Pfam
  PF09342 (DUF1986)
IPR002172

Low-density lipoprotein (LDL) receptor class A repeat
1. SSF57424 (LDL recep...)
  
  1,874 - 1,902
  
  SUPERFAMILY
  SSF57424 (LDL receptor-like module)
  
  1,257 - 1,292
  
  SUPERFAMILY
  SSF57424 (LDL receptor-like module)
  
  1,792 - 1,828
  
  SUPERFAMILY
  SSF57424 (LDL receptor-like module)
  
  347 - 386
  
  SUPERFAMILY
  SSF57424 (LDL receptor-like module)
  
  1,322 - 1,360
  
  SUPERFAMILY
  SSF57424 (LDL receptor-like module)
  
  1,740 - 1,772
  
  SUPERFAMILY
  SSF57424 (LDL receptor-like module)
  
  882 - 919
  
  SUPERFAMILY
  SSF57424 (LDL receptor-like module)
2. PR00261 (LDLRECEPTOR)
  
  1,748 - 1,769
  
  PRINTS
  PR00261 (LDLRECEPTOR)
  
  1,833 - 1,854
  
  PRINTS
  PR00261 (LDLRECEPTOR)
  
  1,877 - 1,898
  
  PRINTS
  PR00261 (LDLRECEPTOR)
  
  1,334 - 1,355
  
  PRINTS
  PR00261 (LDLRECEPTOR)
  
  1,296 - 1,317
  
  PRINTS
  PR00261 (LDLRECEPTOR)
  
  1,802 - 1,823
  
  PRINTS
  PR00261 (LDLRECEPTOR)
3. PS50068 (LDLRA_2)
  
  413 - 455
  
  PROSITE profiles
  PS50068 (LDLRA_2)
  
  1,274 - 1,321
  
  PROSITE profiles
  PS50068 (LDLRA_2)
  
  1,739 - 1,775
  
  PROSITE profiles
  PS50068 (LDLRA_2)
  
  883 - 919
  
  PROSITE profiles
  PS50068 (LDLRA_2)
  
  1,322 - 1,359
  
  PROSITE profiles
  PS50068 (LDLRA_2)
  
  1,791 - 1,830
  
  PROSITE profiles
  PS50068 (LDLRA_2)
  
  1,860 - 1,902
  
  PROSITE profiles
  PS50068 (LDLRA_2)
  
  348 - 385
  
  PROSITE profiles
  PS50068 (LDLRA_2)
4. G3DSA:4.10.40...
  
  1,865 - 1,901
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
  
  1,257 - 1,294
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
  
  1,322 - 1,359
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
  
  390 - 417
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
  
  887 - 920
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
  
  418 - 455
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
  
  1,744 - 1,774
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
  
  1,299 - 1,320
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
  
  1,792 - 1,824
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
  
  348 - 385
  
  GENE3D
  G3DSA:4.10.400.10 (G3DSA:4.10.400.10)
5. SM00192 (LDLa_2)
  
  1,739 - 1,776
  
  SMART
  SM00192 (LDLa_2)
  
  1,253 - 1,292
  
  SMART
  SM00192 (LDLa_2)
  
  1,322 - 1,360
  
  SMART
  SM00192 (LDLa_2)
  
  1,860 - 1,903
  
  SMART
  SM00192 (LDLa_2)
  
  414 - 456
  
  SMART
  SM00192 (LDLa_2)
  
  385 - 413
  
  SMART
  SM00192 (LDLa_2)
  
  348 - 384
  
  SMART
  SM00192 (LDLa_2)
  
  883 - 920
  
  SMART
  SM00192 (LDLa_2)
  
  1,791 - 1,831
  
  SMART
  SM00192 (LDLa_2)
6. PF00057 (Ldl_recept_a)
  
  1,257 - 1,290
  
  Pfam
  PF00057 (Ldl_recept_a)
  
  1,322 - 1,358
  
  Pfam
  PF00057 (Ldl_recept_a)
  
  349 - 384
  
  Pfam
  PF00057 (Ldl_recept_a)
IPR023415

Low-density lipoprotein (LDL) receptor class A, conserved site
1. PS01209 (LDLRA_1)
  
  1,879 - 1,901
  
  PROSITE patterns
  PS01209 (LDLRA_1)
  
  362 - 386
  
  PROSITE patterns
  PS01209 (LDLRA_1)
  
  896 - 918
  
  PROSITE patterns
  PS01209 (LDLRA_1)
  
  1,336 - 1,358
  
  PROSITE patterns
  PS01209 (LDLRA_1)
IPR018114

Serine proteases, trypsin family, histidine active site
1. PS00134 (TRYPSIN_HIS)
  
  671 - 676
  
  PROSITE patterns
  PS00134 (TRYPSIN_HIS)
IPR033116

Serine proteases, trypsin family, serine active site
1. PS00135 (TRYPSIN_SER)
  
  814 - 825
  
  PROSITE patterns
  PS00135 (TRYPSIN_SER)

no IPR

Unintegrated signatures

G3DSA:2.40.10.10

1,517 - 1,633

GENE3D
G3DSA:2.40.10.10 (G3DSA:2.40.10.10)

635 - 668

GENE3D
G3DSA:2.40.10.10 (G3DSA:2.40.10.10)

669 - 871

GENE3D
G3DSA:2.40.10.10 (G3DSA:2.40.10.10)
cd00112 (LDLa)

887 - 918

CDD
cd00112 (LDLa)

1,744 - 1,769

CDD
cd00112 (LDLa)

1,323 - 1,358

CDD
cd00112 (LDLa)

1,867 - 1,901

CDD
cd00112 (LDLa)

1,792 - 1,825

CDD
cd00112 (LDLa)

349 - 384

CDD
cd00112 (LDLa)

1,257 - 1,290

CDD
cd00112 (LDLa)
mobidb-lite (disord...)

1,105 - 1,124

MobiDB Lite
mobidb-lite (disorder_prediction)

1,004 - 1,023

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative binding s...

354K

putative binding surface
354K, 363I, 374D, 375C
CDD
cd00112 (LDLa)

363I

putative binding surface
354K, 363I, 374D, 375C
CDD
cd00112 (LDLa)

374D

putative binding surface
354K, 363I, 374D, 375C
CDD
cd00112 (LDLa)

375C

putative binding surface
354K, 363I, 374D, 375C
CDD
cd00112 (LDLa)
calcium-binding si...

367Q

calcium-binding site
367Q, 370D, 374D, 380D, 381E
CDD
cd00112 (LDLa)

370D

calcium-binding site
367Q, 370D, 374D, 380D, 381E
CDD
cd00112 (LDLa)

374D

calcium-binding site
367Q, 370D, 374D, 380D, 381E
CDD
cd00112 (LDLa)

380D

calcium-binding site
367Q, 370D, 374D, 380D, 381E
CDD
cd00112 (LDLa)

381E

calcium-binding site
367Q, 370D, 374D, 380D, 381E
CDD
cd00112 (LDLa)
D-X-S-D-E motif cd...

377D

D-X-S-D-E motif
377D, 378V, 379S, 380D, 381E
CDD
cd00112 (LDLa)

378V

D-X-S-D-E motif
377D, 378V, 379S, 380D, 381E
CDD
cd00112 (LDLa)

379S

D-X-S-D-E motif
377D, 378V, 379S, 380D, 381E
CDD
cd00112 (LDLa)

380D

D-X-S-D-E motif
377D, 378V, 379S, 380D, 381E
CDD
cd00112 (LDLa)

381E

D-X-S-D-E motif
377D, 378V, 379S, 380D, 381E
CDD
cd00112 (LDLa)
cleavage site cd00...

635V

cleavage site
635V
CDD
cd00190 (Tryp_SPc)
active site cd00190

675H

active site
675H, 723D, 820S
CDD
cd00190 (Tryp_SPc)

723D

active site
675H, 723D, 820S
CDD
cd00190 (Tryp_SPc)

820S

active site
675H, 723D, 820S
CDD
cd00190 (Tryp_SPc)
substrate binding ...

814D

substrate binding sites
814D, 842S, 844G
CDD
cd00190 (Tryp_SPc)

842S

substrate binding sites
814D, 842S, 844G
CDD
cd00190 (Tryp_SPc)

844G

substrate binding sites
814D, 842S, 844G
CDD
cd00190 (Tryp_SPc)
putative binding s...

887F

putative binding surface
887F, 897I, 908D, 909C
CDD
cd00112 (LDLa)

897I

putative binding surface
887F, 897I, 908D, 909C
CDD
cd00112 (LDLa)

908D

putative binding surface
887F, 897I, 908D, 909C
CDD
cd00112 (LDLa)

909C

putative binding surface
887F, 897I, 908D, 909C
CDD
cd00112 (LDLa)
calcium-binding si...

901R

calcium-binding site
901R, 904D, 908D, 914D, 915E
CDD
cd00112 (LDLa)

904D

calcium-binding site
901R, 904D, 908D, 914D, 915E
CDD
cd00112 (LDLa)

908D

calcium-binding site
901R, 904D, 908D, 914D, 915E
CDD
cd00112 (LDLa)

914D

calcium-binding site
901R, 904D, 908D, 914D, 915E
CDD
cd00112 (LDLa)

915E

calcium-binding site
901R, 904D, 908D, 914D, 915E
CDD
cd00112 (LDLa)
D-X-S-D-E motif cd...

911G

D-X-S-D-E motif
911G, 912G, 913E, 914D, 915E
CDD
cd00112 (LDLa)

912G

D-X-S-D-E motif
911G, 912G, 913E, 914D, 915E
CDD
cd00112 (LDLa)

913E

D-X-S-D-E motif
911G, 912G, 913E, 914D, 915E
CDD
cd00112 (LDLa)

914D

D-X-S-D-E motif
911G, 912G, 913E, 914D, 915E
CDD
cd00112 (LDLa)

915E

D-X-S-D-E motif
911G, 912G, 913E, 914D, 915E
CDD
cd00112 (LDLa)
putative binding s...

1,260F

putative binding surface
1,260F, 1,269I, 1,280D, 1,281C
CDD
cd00112 (LDLa)

1,269I

putative binding surface
1,260F, 1,269I, 1,280D, 1,281C
CDD
cd00112 (LDLa)

1,280D

putative binding surface
1,260F, 1,269I, 1,280D, 1,281C
CDD
cd00112 (LDLa)

1,281C

putative binding surface
1,260F, 1,269I, 1,280D, 1,281C
CDD
cd00112 (LDLa)
calcium-binding si...

1,273L

calcium-binding site
1,273L, 1,276D, 1,280D, 1,286D, 1,287E
CDD
cd00112 (LDLa)

1,276D

calcium-binding site
1,273L, 1,276D, 1,280D, 1,286D, 1,287E
CDD
cd00112 (LDLa)

1,280D

calcium-binding site
1,273L, 1,276D, 1,280D, 1,286D, 1,287E
CDD
cd00112 (LDLa)

1,286D

calcium-binding site
1,273L, 1,276D, 1,280D, 1,286D, 1,287E
CDD
cd00112 (LDLa)

1,287E

calcium-binding site
1,273L, 1,276D, 1,280D, 1,286D, 1,287E
CDD
cd00112 (LDLa)
D-X-S-D-E motif cd...

1,283D

D-X-S-D-E motif
1,283D, 1,284G, 1,285T, 1,286D, 1,287E
CDD
cd00112 (LDLa)

1,284G

D-X-S-D-E motif
1,283D, 1,284G, 1,285T, 1,286D, 1,287E
CDD
cd00112 (LDLa)

1,285T

D-X-S-D-E motif
1,283D, 1,284G, 1,285T, 1,286D, 1,287E
CDD
cd00112 (LDLa)

1,286D

D-X-S-D-E motif
1,283D, 1,284G, 1,285T, 1,286D, 1,287E
CDD
cd00112 (LDLa)

1,287E

D-X-S-D-E motif
1,283D, 1,284G, 1,285T, 1,286D, 1,287E
CDD
cd00112 (LDLa)
putative binding s...

1,328F

putative binding surface
1,328F, 1,337I, 1,348E, 1,349C
CDD
cd00112 (LDLa)

1,337I

putative binding surface
1,328F, 1,337I, 1,348E, 1,349C
CDD
cd00112 (LDLa)

1,348E

putative binding surface
1,328F, 1,337I, 1,348E, 1,349C
CDD
cd00112 (LDLa)

1,349C

putative binding surface
1,328F, 1,337I, 1,348E, 1,349C
CDD
cd00112 (LDLa)
calcium-binding si...

1,341N

calcium-binding site
1,341N, 1,344D, 1,348E, 1,354D, 1,355E
CDD
cd00112 (LDLa)

1,344D

calcium-binding site
1,341N, 1,344D, 1,348E, 1,354D, 1,355E
CDD
cd00112 (LDLa)

1,348E

calcium-binding site
1,341N, 1,344D, 1,348E, 1,354D, 1,355E
CDD
cd00112 (LDLa)

1,354D

calcium-binding site
1,341N, 1,344D, 1,348E, 1,354D, 1,355E
CDD
cd00112 (LDLa)

1,355E

calcium-binding site
1,341N, 1,344D, 1,348E, 1,354D, 1,355E
CDD
cd00112 (LDLa)
D-X-S-D-E motif cd...

1,351Q

D-X-S-D-E motif
1,351Q, 1,352N, 1,353D, 1,354D, 1,355E
CDD
cd00112 (LDLa)

1,352N

D-X-S-D-E motif
1,351Q, 1,352N, 1,353D, 1,354D, 1,355E
CDD
cd00112 (LDLa)

1,353D

D-X-S-D-E motif
1,351Q, 1,352N, 1,353D, 1,354D, 1,355E
CDD
cd00112 (LDLa)

1,354D

D-X-S-D-E motif
1,351Q, 1,352N, 1,353D, 1,354D, 1,355E
CDD
cd00112 (LDLa)

1,355E

D-X-S-D-E motif
1,351Q, 1,352N, 1,353D, 1,354D, 1,355E
CDD
cd00112 (LDLa)
putative binding s...

1,751I

putative binding surface
1,751I, 1,762Q, 1,763C
CDD
cd00112 (LDLa)

1,762Q

putative binding surface
1,751I, 1,762Q, 1,763C
CDD
cd00112 (LDLa)

1,763C

putative binding surface
1,751I, 1,762Q, 1,763C
CDD
cd00112 (LDLa)
calcium-binding si...

1,755R

calcium-binding site
1,755R, 1,758D, 1,762Q, 1,768D, 1,769E
CDD
cd00112 (LDLa)

1,758D

calcium-binding site
1,755R, 1,758D, 1,762Q, 1,768D, 1,769E
CDD
cd00112 (LDLa)

1,762Q

calcium-binding site
1,755R, 1,758D, 1,762Q, 1,768D, 1,769E
CDD
cd00112 (LDLa)

1,768D

calcium-binding site
1,755R, 1,758D, 1,762Q, 1,768D, 1,769E
CDD
cd00112 (LDLa)

1,769E

calcium-binding site
1,755R, 1,758D, 1,762Q, 1,768D, 1,769E
CDD
cd00112 (LDLa)
D-X-S-D-E motif cd...

1,765D

D-X-S-D-E motif
1,765D, 1,766G, 1,767N, 1,768D, 1,769E
CDD
cd00112 (LDLa)

1,766G

D-X-S-D-E motif
1,765D, 1,766G, 1,767N, 1,768D, 1,769E
CDD
cd00112 (LDLa)

1,767N

D-X-S-D-E motif
1,765D, 1,766G, 1,767N, 1,768D, 1,769E
CDD
cd00112 (LDLa)

1,768D

D-X-S-D-E motif
1,765D, 1,766G, 1,767N, 1,768D, 1,769E
CDD
cd00112 (LDLa)

1,769E

D-X-S-D-E motif
1,765D, 1,766G, 1,767N, 1,768D, 1,769E
CDD
cd00112 (LDLa)
putative binding s...

1,797M

putative binding surface
1,797M, 1,805L, 1,816D, 1,817C
CDD
cd00112 (LDLa)

1,805L

putative binding surface
1,797M, 1,805L, 1,816D, 1,817C
CDD
cd00112 (LDLa)

1,816D

putative binding surface
1,797M, 1,805L, 1,816D, 1,817C
CDD
cd00112 (LDLa)

1,817C

putative binding surface
1,797M, 1,805L, 1,816D, 1,817C
CDD
cd00112 (LDLa)
calcium-binding si...

1,809L

calcium-binding site
1,809L, 1,812D, 1,816D, 1,822D, 1,823E
CDD
cd00112 (LDLa)

1,812D

calcium-binding site
1,809L, 1,812D, 1,816D, 1,822D, 1,823E
CDD
cd00112 (LDLa)

1,816D

calcium-binding site
1,809L, 1,812D, 1,816D, 1,822D, 1,823E
CDD
cd00112 (LDLa)

1,822D

calcium-binding site
1,809L, 1,812D, 1,816D, 1,822D, 1,823E
CDD
cd00112 (LDLa)

1,823E

calcium-binding site
1,809L, 1,812D, 1,816D, 1,822D, 1,823E
CDD
cd00112 (LDLa)
D-X-S-D-E motif cd...

1,819D

D-X-S-D-E motif
1,819D, 1,820G, 1,821T, 1,822D, 1,823E
CDD
cd00112 (LDLa)

1,820G

D-X-S-D-E motif
1,819D, 1,820G, 1,821T, 1,822D, 1,823E
CDD
cd00112 (LDLa)

1,821T

D-X-S-D-E motif
1,819D, 1,820G, 1,821T, 1,822D, 1,823E
CDD
cd00112 (LDLa)

1,822D

D-X-S-D-E motif
1,819D, 1,820G, 1,821T, 1,822D, 1,823E
CDD
cd00112 (LDLa)

1,823E

D-X-S-D-E motif
1,819D, 1,820G, 1,821T, 1,822D, 1,823E
CDD
cd00112 (LDLa)
putative binding s...

1,867Y

putative binding surface
1,867Y, 1,880V, 1,891D, 1,892C
CDD
cd00112 (LDLa)

1,880V

putative binding surface
1,867Y, 1,880V, 1,891D, 1,892C
CDD
cd00112 (LDLa)

1,891D

putative binding surface
1,867Y, 1,880V, 1,891D, 1,892C
CDD
cd00112 (LDLa)

1,892C

putative binding surface
1,867Y, 1,880V, 1,891D, 1,892C
CDD
cd00112 (LDLa)
calcium-binding si...

1,884M

calcium-binding site
1,884M, 1,887D, 1,891D, 1,897D, 1,898E
CDD
cd00112 (LDLa)

1,887D

calcium-binding site
1,884M, 1,887D, 1,891D, 1,897D, 1,898E
CDD
cd00112 (LDLa)

1,891D

calcium-binding site
1,884M, 1,887D, 1,891D, 1,897D, 1,898E
CDD
cd00112 (LDLa)

1,897D

calcium-binding site
1,884M, 1,887D, 1,891D, 1,897D, 1,898E
CDD
cd00112 (LDLa)

1,898E

calcium-binding site
1,884M, 1,887D, 1,891D, 1,897D, 1,898E
CDD
cd00112 (LDLa)
D-X-S-D-E motif cd...

1,894N

D-X-S-D-E motif
1,894N, 1,895G, 1,896E, 1,897D, 1,898E
CDD
cd00112 (LDLa)

1,895G

D-X-S-D-E motif
1,894N, 1,895G, 1,896E, 1,897D, 1,898E
CDD
cd00112 (LDLa)

1,896E

D-X-S-D-E motif
1,894N, 1,895G, 1,896E, 1,897D, 1,898E
CDD
cd00112 (LDLa)

1,897D

D-X-S-D-E motif
1,894N, 1,895G, 1,896E, 1,897D, 1,898E
CDD
cd00112 (LDLa)

1,898E

D-X-S-D-E motif
1,894N, 1,895G, 1,896E, 1,897D, 1,898E
CDD
cd00112 (LDLa)

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding

Cellular Component

GO:0016020 membrane

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Entry type

Status

Per-residue features