KWMTBOMO04989

Protein

Length

1,698 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
487 - 706
Endonuclease/exonuclease/phosphatase (IPR005135)
975 - 1,244
Reverse transcriptase domain (IPR000477)
1,407 - 1,539
Ribonuclease H-like domain (IPR012337)
Ribonuclease H domain (IPR002156)

1 200 400 600 800 1000 1200 1400 1698

Detailed signature matches

IPR005135

Endonuclease/exonuclease/phosphatase
1. PF14529 (Exo_endo_p...)
  
  583 - 700
  
  Pfam
  PF14529 (Exo_endo_phos_2)
2. G3DSA:3.60.10.10
  
  487 - 706
  
  GENE3D
  G3DSA:3.60.10.10 (G3DSA:3.60.10.10)
3. SSF56219 (DNase I-like)
  
  487 - 706
  
  SUPERFAMILY
  SSF56219 (DNase I-like)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  997 - 1,244
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  975 - 1,244
  
  PROSITE profiles
  PS50878 (RT_POL)
IPR012337

Ribonuclease H-like domain
1. G3DSA:3.30.42...
  
  1,410 - 1,537
  
  GENE3D
  G3DSA:3.30.420.10 (G3DSA:3.30.420.10)
2. SSF53098 (Ribonucle...)
  
  1,409 - 1,538
  
  SUPERFAMILY
  SSF53098 (Ribonuclease H-like)
IPR002156

Ribonuclease H domain
1. PF00075 (RNase_H)
  
  1,411 - 1,538
  
  Pfam
  PF00075 (RNase_H)
2. PS50879 (RNASE_H)
  
  1,407 - 1,539
  
  PROSITE profiles
  PS50879 (RNASE_H)

no IPR

Unintegrated signatures

Coil

821 - 841

COILS
Coil (Coil)
SSF56672 (DNA/RNA p...)

928 - 1,210

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd01650 (RT_nLTR_like)

988 - 1,244

CDD
cd01650 (RT_nLTR_like)
cd09077 (R1-I-EN)

487 - 704

CDD
cd09077 (R1-I-EN)
cd09276 (Rnase_HI_R...)

1,412 - 1,530

CDD
cd09276 (Rnase_HI_RT_non_LTR)
mobidb-lite (disord...)

1 - 115

MobiDB Lite
mobidb-lite (disorder_prediction)

902 - 929

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

phosphate binding ...

492N

phosphate binding site
492N, 494Q, 519E, 589Y, 617D, 619N, 697H
CDD
cd09077 (R1-I-EN)

494Q

phosphate binding site
492N, 494Q, 519E, 589Y, 617D, 619N, 697H
CDD
cd09077 (R1-I-EN)

519E

phosphate binding site
492N, 494Q, 519E, 589Y, 617D, 619N, 697H
CDD
cd09077 (R1-I-EN)

589Y

phosphate binding site
492N, 494Q, 519E, 589Y, 617D, 619N, 697H
CDD
cd09077 (R1-I-EN)

617D

phosphate binding site
492N, 494Q, 519E, 589Y, 617D, 619N, 697H
CDD
cd09077 (R1-I-EN)

619N

phosphate binding site
492N, 494Q, 519E, 589Y, 617D, 619N, 697H
CDD
cd09077 (R1-I-EN)

697H

phosphate binding site
492N, 494Q, 519E, 589Y, 617D, 619N, 697H
CDD
cd09077 (R1-I-EN)
putative catalytic...

492N

putative catalytic site
492N, 519E, 589Y, 617D, 619N, 671D, 696D, 697H
CDD
cd09077 (R1-I-EN)

519E

putative catalytic site
492N, 519E, 589Y, 617D, 619N, 671D, 696D, 697H
CDD
cd09077 (R1-I-EN)

589Y

putative catalytic site
492N, 519E, 589Y, 617D, 619N, 671D, 696D, 697H
CDD
cd09077 (R1-I-EN)

617D

putative catalytic site
492N, 519E, 589Y, 617D, 619N, 671D, 696D, 697H
CDD
cd09077 (R1-I-EN)

619N

putative catalytic site
492N, 519E, 589Y, 617D, 619N, 671D, 696D, 697H
CDD
cd09077 (R1-I-EN)

671D

putative catalytic site
492N, 519E, 589Y, 617D, 619N, 671D, 696D, 697H
CDD
cd09077 (R1-I-EN)

696D

putative catalytic site
492N, 519E, 589Y, 617D, 619N, 671D, 696D, 697H
CDD
cd09077 (R1-I-EN)

697H

putative catalytic site
492N, 519E, 589Y, 617D, 619N, 671D, 696D, 697H
CDD
cd09077 (R1-I-EN)
putative metal bin...

519E

putative metal binding site
519E, 696D
CDD
cd09077 (R1-I-EN)

696D

putative metal binding site
519E, 696D
CDD
cd09077 (R1-I-EN)
putative NTP bindi...

1,077D

putative NTP binding site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,167D
CDD
cd01650 (RT_nLTR_like)

1,078I

putative NTP binding site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,167D
CDD
cd01650 (RT_nLTR_like)

1,079E

putative NTP binding site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,167D
CDD
cd01650 (RT_nLTR_like)

1,080G

putative NTP binding site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,167D
CDD
cd01650 (RT_nLTR_like)

1,081A

putative NTP binding site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,167D
CDD
cd01650 (RT_nLTR_like)

1,082F

putative NTP binding site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,167D
CDD
cd01650 (RT_nLTR_like)

1,135Q

putative NTP binding site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,167D
CDD
cd01650 (RT_nLTR_like)

1,167D

putative NTP binding site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,167D
CDD
cd01650 (RT_nLTR_like)
putative active si...

1,077D

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,078I

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,079E

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,080G

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,081A

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,082F

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,135Q

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,136G

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,165F

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,167D

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,168D

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,240L

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)

1,241G

putative active site
1,077D, 1,078I, 1,079E, 1,080G, 1,081A, 1,082F, 1,135Q, 1,136G, 1,165F, 1,167D, 1,168D, 1,240L, 1,241G
CDD
cd01650 (RT_nLTR_like)
putative nucleic a...

1,136G

putative nucleic acid binding site
1,136G
CDD
cd01650 (RT_nLTR_like)
RNA/DNA hybrid bin...

1,416D

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,417G

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,418S

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,419K

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,449T

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,450V

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,451Y

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,454E

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,478D

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

1,517W

RNA/DNA hybrid binding site
1,416D, 1,417G, 1,418S, 1,419K, 1,449T, 1,450V, 1,451Y, 1,454E, 1,478D, 1,517W
CDD
cd09276 (Rnase_HI_RT_non_LTR)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO04989

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component