KWMTBOMO04806

Protein

Length

1,043 amino acids

Protein family membership

Ubiquitin/SUMO-activating enzyme E1 (IPR000011)
- Ubiquitin-activating enzyme E1 (IPR018075)

Domains and repeats

Domain
39 - 426
NAD(P)-binding domain (IPR016040)
THIF-type NAD/FAD binding fold (IPR000594)
434 - 936
NAD(P)-binding domain (IPR016040)
THIF-type NAD/FAD binding fold (IPR000594)
Domain
222 - 290
Ubiquitin-activating enzyme E1, FCCH domain (IPR032418)
291 - 352
Ubiquitin-activating enzyme E1, four-helix bundle (IPR032420)
630 - 875
Ubiquitin-activating enzyme, catalytic cysteine domain (IPR019572)
913 - 1,038
Ubiquitin-activating enzyme E1, C-terminal (IPR018965)
Domain
631 - 663
Ubiquitin activating enzyme, alpha domain (IPR023318)

1 100 200 300 400 500 600 700 800 900 1043

Detailed signature matches

IPR000011

Ubiquitin/SUMO-activating enzyme E1
1. PR01849 (UBIQUITINACT)
  
  689 - 716
  
  PRINTS
  PR01849 (UBIQUITINACT)
  
  537 - 562
  
  PRINTS
  PR01849 (UBIQUITINACT)
  
  490 - 513
  
  PRINTS
  PR01849 (UBIQUITINACT)
  
  182 - 209
  
  PRINTS
  PR01849 (UBIQUITINACT)
  
  69 - 93
  
  PRINTS
  PR01849 (UBIQUITINACT)
IPR018075

Ubiquitin-activating enzyme E1
1. TIGR01408
  
  42 - 1,041
  
  TIGRFAMs
  TIGR01408 (TIGR01408)
IPR016040

NAD(P)-binding domain
1. G3DSA:3.40.50...
  
  434 - 630
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
  
  684 - 785
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
  
  39 - 251
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
  
  800 - 933
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
  
  288 - 426
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
IPR000594

THIF-type NAD/FAD binding fold
1. PF00899 (ThiF)
  
  444 - 936
  
  Pfam
  PF00899 (ThiF)
  
  48 - 424
  
  Pfam
  PF00899 (ThiF)
2. SSF69572 (Activatin...)
  
  42 - 426
  
  SUPERFAMILY
  SSF69572 (Activating enzymes of the ubiquitin-like proteins)
  
  438 - 931
  
  SUPERFAMILY
  SSF69572 (Activating enzymes of the ubiquitin-like proteins)
IPR032418

Ubiquitin-activating enzyme E1, FCCH domain
1. PF16190 (E1_FCCH)
  
  222 - 290
  
  Pfam
  PF16190 (E1_FCCH)
IPR032420

Ubiquitin-activating enzyme E1, four-helix bundle
1. PF16191 (E1_4HB)
  
  291 - 352
  
  Pfam
  PF16191 (E1_4HB)
IPR019572

Ubiquitin-activating enzyme, catalytic cysteine domain
1. PF10585 (UBA_e1_thi...)
  
  630 - 875
  
  Pfam
  PF10585 (UBA_e1_thiolCys)
IPR023318

Ubiquitin activating enzyme, alpha domain
1. G3DSA:1.10.10...
  
  631 - 663
  
  GENE3D
  G3DSA:1.10.10.520 (G3DSA:1.10.10.520)
IPR018965

Ubiquitin-activating enzyme E1, C-terminal
1. PF09358 (E1_UFD)
  
  946 - 1,038
  
  Pfam
  PF09358 (E1_UFD)
2. SM00985 (UBA_e1_C_a_2)
  
  913 - 1,038
  
  SMART
  SM00985 (UBA_e1_C_a_2)
IPR018074

Ubiquitin-activating enzyme E1, conserved site
1. PS00536 (UBIQUITIN_...)
  
  404 - 412
  
  PROSITE patterns
  PS00536 (UBIQUITIN_ACTIVAT_1)
IPR033127

Ubiquitin-activating enzyme E1, Cys active site
1. PS00865 (UBIQUITIN_...)
  
  622 - 630
  
  PROSITE patterns
  PS00865 (UBIQUITIN_ACTIVAT_2)

no IPR

Unintegrated signatures

cd01490 (Ube1_repeat2)

463 - 996

CDD
cd01490 (Ube1_repeat2)
cd01491 (Ube1_repeat1)

47 - 428

CDD
cd01491 (Ube1_repeat1)
mobidb-lite (disord...)

1 - 36

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

interdomain dimer ...

47L

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

49S

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

50R

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

51Q

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

52L

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

53Y

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

54V

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

55L

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

57H

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

79E

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

82K

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

83N

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

86L

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

102V

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

103A

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

105L

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

106S

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

107S

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

109F

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

116I

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

127Q

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

130E

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

131L

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

187L

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

392A

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

396G

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

400Q

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)

422I

interdomain dimer interaction
47L, 49S, 50R, 51Q, 52L, 53Y, 54V, 55L, 57H, 79E, 82K, 83N, 86L, 102V, 103A, 105L, 106S, 107S, 109F, 116I, 127Q, 130E, 131L, 187L, 392A, 396G, 400Q, 422I
CDD
cd01491 (Ube1_repeat1)
putative ATP bindi...

468G

putative ATP binding site
468G, 470G, 472I, 496D, 498D, 507R, 520K, 566A, 572A
CDD
cd01490 (Ube1_repeat2)

470G

putative ATP binding site
468G, 470G, 472I, 496D, 498D, 507R, 520K, 566A, 572A
CDD
cd01490 (Ube1_repeat2)

472I

putative ATP binding site
468G, 470G, 472I, 496D, 498D, 507R, 520K, 566A, 572A
CDD
cd01490 (Ube1_repeat2)

496D

putative ATP binding site
468G, 470G, 472I, 496D, 498D, 507R, 520K, 566A, 572A
CDD
cd01490 (Ube1_repeat2)

498D

putative ATP binding site
468G, 470G, 472I, 496D, 498D, 507R, 520K, 566A, 572A
CDD
cd01490 (Ube1_repeat2)

507R

putative ATP binding site
468G, 470G, 472I, 496D, 498D, 507R, 520K, 566A, 572A
CDD
cd01490 (Ube1_repeat2)

520K

putative ATP binding site
468G, 470G, 472I, 496D, 498D, 507R, 520K, 566A, 572A
CDD
cd01490 (Ube1_repeat2)

566A

putative ATP binding site
468G, 470G, 472I, 496D, 498D, 507R, 520K, 566A, 572A
CDD
cd01490 (Ube1_repeat2)

572A

putative ATP binding site
468G, 470G, 472I, 496D, 498D, 507R, 520K, 566A, 572A
CDD
cd01490 (Ube1_repeat2)
putative substrate...

470G

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

472I

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

567L

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

568D

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

573R

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

592T

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

593L

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

597G

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

598N

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

612S

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

616P

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)

617P

putative substrate interface
470G, 472I, 567L, 568D, 573R, 592T, 593L, 597G, 598N, 612S, 616P, 617P
CDD
cd01490 (Ube1_repeat2)
catalytic residue ...

624C

catalytic residue
624C
CDD
cd01490 (Ube1_repeat2)

GO term prediction

Biological Process

GO:0006464 cellular protein modification process

Molecular Function

GO:0008641 small protein activating enzyme activity
GO:0016881 acid-amino acid ligase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features