KWMTBOMO04605

Protein

Length

433 amino acids

Protein family membership

Enolase (IPR000941)

Domains and repeats

Domain
3 - 140
Enolase N-terminal domain-like (IPR029017)
Enolase, N-terminal (IPR020811)
Domain
128 - 432
Enolase C-terminal domain-like (IPR029065)
Enolase, C-terminal TIM barrel domain (IPR020810)

1 50 100 150 200 250 300 350 400 433

Detailed signature matches

IPR000941

Enolase
1. PIRSF001400 (Enolase)
  
  1 - 431
  
  PIRSF
  PIRSF001400 (Enolase)
2. MF_00318 (Enolase)
  
  1 - 418
  
  HAMAP
  MF_00318 (Enolase)
3. TIGR01060
  
  3 - 429
  
  TIGRFAMs
  TIGR01060 (TIGR01060)
4. cd03313 (enolase)
  
  5 - 417
  
  CDD
  cd03313 (enolase)
5. PR00148 (ENOLASE)
  
  341 - 355
  
  PRINTS
  PR00148 (ENOLASE)
  
  35 - 49
  
  PRINTS
  PR00148 (ENOLASE)
  
  107 - 123
  
  PRINTS
  PR00148 (ENOLASE)
  
  318 - 329
  
  PRINTS
  PR00148 (ENOLASE)
  
  370 - 387
  
  PRINTS
  PR00148 (ENOLASE)
  
  164 - 177
  
  PRINTS
  PR00148 (ENOLASE)
IPR029017

Enolase N-terminal domain-like
1. G3DSA:3.30.39...
  
  3 - 127
  
  GENE3D
  G3DSA:3.30.390.10 (G3DSA:3.30.390.10)
2. SSF54826 (Enolase N...)
  
  3 - 140
  
  SUPERFAMILY
  SSF54826 (Enolase N-terminal domain-like)
IPR020811

Enolase, N-terminal
1. SM01193 (Enolase_N_3)
  
  3 - 134
  
  SMART
  SM01193 (Enolase_N_3)
2. PF03952 (Enolase_N)
  
  3 - 134
  
  Pfam
  PF03952 (Enolase_N)
IPR029065

Enolase C-terminal domain-like
1. SSF51604 (Enolase C...)
  
  143 - 431
  
  SUPERFAMILY
  SSF51604 (Enolase C-terminal domain-like)
2. G3DSA:3.20.20...
  
  128 - 432
  
  GENE3D
  G3DSA:3.20.20.120 (G3DSA:3.20.20.120)
IPR020810

Enolase, C-terminal TIM barrel domain
1. SM01192 (Enolase_C_3)
  
  142 - 432
  
  SMART
  SM01192 (Enolase_C_3)
2. PF00113 (Enolase_C)
  
  143 - 431
  
  Pfam
  PF00113 (Enolase_C)
IPR020809

Enolase, conserved site
1. PS00164 (ENOLASE)
  
  341 - 354
  
  PROSITE patterns
  PS00164 (ENOLASE)

no IPR

Unintegrated signatures

SFLDS00001 (Enolase)

9 - 429

SFLD
SFLDS00001 (Enolase)

Residue annotation

dimer interface cd...

7K

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

9R

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

10Q

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

11I

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

12F

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

13D

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

14S

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

15R

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

16G

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

17N

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

21E

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

32R

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

159A

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

160G

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

161N

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

182M

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

183R

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

186S

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

187E

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

190H

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

191H

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

206A

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

207V

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

214A

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

216N

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

376E

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

377T

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

378E

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

401R

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

402S

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

403E

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

405L

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

406A

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

409N

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

412L

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

413R

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)

416E

dimer interface
7K, 9R, 10Q, 11I, 12F, 13D, 14S, 15R, 16G, 17N, 21E, 32R, 159A, 160G, 161N, 182M, 183R, 186S, 187E, 190H, 191H, 206A, 207V, 214A, 216N, 376E, 377T, 378E, 401R, 402S, 403E, 405L, 406A, 409N, 412L, 413R, 416E
CDD
cd03313 (enolase)
metal binding site...

40S

metal binding site
40S, 245D, 294E, 319D
CDD
cd03313 (enolase)

245D

metal binding site
40S, 245D, 294E, 319D
CDD
cd03313 (enolase)

294E

metal binding site
40S, 245D, 294E, 319D
CDD
cd03313 (enolase)

319D

metal binding site
40S, 245D, 294E, 319D
CDD
cd03313 (enolase)
substrate binding ...

158H

substrate binding pocket
158H, 210E, 344K, 372H, 373R, 374S, 395K
CDD
cd03313 (enolase)

210E

substrate binding pocket
158H, 210E, 344K, 372H, 373R, 374S, 395K
CDD
cd03313 (enolase)

344K

substrate binding pocket
158H, 210E, 344K, 372H, 373R, 374S, 395K
CDD
cd03313 (enolase)

372H

substrate binding pocket
158H, 210E, 344K, 372H, 373R, 374S, 395K
CDD
cd03313 (enolase)

373R

substrate binding pocket
158H, 210E, 344K, 372H, 373R, 374S, 395K
CDD
cd03313 (enolase)

374S

substrate binding pocket
158H, 210E, 344K, 372H, 373R, 374S, 395K
CDD
cd03313 (enolase)

395K

substrate binding pocket
158H, 210E, 344K, 372H, 373R, 374S, 395K
CDD
cd03313 (enolase)
SFLDS00001

245D

SFLD_Res03
245D, 294E, 319D
SFLD
SFLDS00001 (Enolase)

294E

SFLD_Res03
245D, 294E, 319D
SFLD
SFLDS00001 (Enolase)

319D

SFLD_Res03
245D, 294E, 319D
SFLD
SFLDS00001 (Enolase)

GO term prediction

Biological Process

GO:0006096 glycolytic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity

Cellular Component

GO:0000015 phosphopyruvate hydratase complex

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Entry type

Status

Per-residue features