KWMTBOMO04576

Protein

Length

1,500 amino acids

Protein family membership

Haem peroxidase (IPR010255)
- Haem peroxidase, animal (IPR019791)

Domains and repeats

Domain
804 - 946
EF-hand domain pair (IPR011992)
EF-hand domain (IPR002048)
1,037 - 1,181
Ferric reductase transmembrane component-like domain (IPR013130)
1,216 - 1,321
Riboflavin synthase-like beta-barrel (IPR017938)
Ferredoxin reductase-type FAD-binding domain (IPR017927)
FAD-binding 8 (IPR013112)
1,325 - 1,480
Ferric reductase, NAD binding domain (IPR013121)

1 200 400 600 800 1000 1200 1400 1500

Detailed signature matches

IPR010255

Haem peroxidase
1. SSF48113 (Heme-depe...)
  
  32 - 585
  
  SUPERFAMILY
  SSF48113 (Heme-dependent peroxidases)
IPR019791

Haem peroxidase, animal
1. PF03098 (An_peroxidase)
  
  37 - 556
  
  Pfam
  PF03098 (An_peroxidase)
2. PS50292 (PEROXIDASE_3)
  
  25 - 579
  
  PROSITE profiles
  PS50292 (PEROXIDASE_3)
3. G3DSA:1.10.64...
  
  122 - 567
  
  GENE3D
  G3DSA:1.10.640.10 (G3DSA:1.10.640.10)
4. PR00457 (ANPEROXIDASE)
  
  104 - 119
  
  PRINTS
  PR00457 (ANPEROXIDASE)
  
  280 - 306
  
  PRINTS
  PR00457 (ANPEROXIDASE)
  
  329 - 339
  
  PRINTS
  PR00457 (ANPEROXIDASE)
  
  237 - 255
  
  PRINTS
  PR00457 (ANPEROXIDASE)
  
  461 - 481
  
  PRINTS
  PR00457 (ANPEROXIDASE)
  
  255 - 275
  
  PRINTS
  PR00457 (ANPEROXIDASE)
IPR011992

EF-hand domain pair
1. G3DSA:1.10.23...
  
  804 - 946
  
  GENE3D
  G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
2. SSF47473 (EF-hand)
  
  805 - 931
  
  SUPERFAMILY
  SSF47473 (EF-hand)
IPR002048

EF-hand domain
1. SM00054 (efh_1)
  
  822 - 850
  
  SMART
  SM00054 (efh_1)
  
  858 - 886
  
  SMART
  SM00054 (efh_1)
2. PS50222 (EF_HAND_2)
  
  818 - 853
  
  PROSITE profiles
  PS50222 (EF_HAND_2)
  
  899 - 934
  
  PROSITE profiles
  PS50222 (EF_HAND_2)
  
  854 - 889
  
  PROSITE profiles
  PS50222 (EF_HAND_2)
3. cd00051 (EFh)
  
  823 - 884
  
  CDD
  cd00051 (EFh)
4. PF00036 (EF-hand_1)
  
  823 - 845
  
  Pfam
  PF00036 (EF-hand_1)
IPR013130

Ferric reductase transmembrane component-like domain
1. PF01794 (Ferric_reduct)
  
  1,037 - 1,181
  
  Pfam
  PF01794 (Ferric_reduct)
IPR017938

Riboflavin synthase-like beta-barrel
1. SSF63380 (Riboflavi...)
  
  1,220 - 1,317
  
  SUPERFAMILY
  SSF63380 (Riboflavin synthase domain-like)
IPR017927

Ferredoxin reductase-type FAD-binding domain
1. PS51384 (FAD_FR)
  
  1,216 - 1,321
  
  PROSITE profiles
  PS51384 (FAD_FR)
IPR013112

FAD-binding 8
1. PF08022 (FAD_binding_8)
  
  1,223 - 1,316
  
  Pfam
  PF08022 (FAD_binding_8)
IPR013121

Ferric reductase, NAD binding domain
1. PF08030 (NAD_binding_6)
  
  1,325 - 1,480
  
  Pfam
  PF08030 (NAD_binding_6)
IPR018247

EF-Hand 1, calcium-binding site
1. PS00018 (EF_HAND_1)
  
  831 - 843
  
  PROSITE patterns
  PS00018 (EF_HAND_1)
  
  867 - 879
  
  PROSITE patterns
  PS00018 (EF_HAND_1)

no IPR

Unintegrated signatures

G3DSA:2.40.30.10

1,220 - 1,316

GENE3D
G3DSA:2.40.30.10 (G3DSA:2.40.30.10)
G3DSA:3.40.50.80

1,328 - 1,490

GENE3D
G3DSA:3.40.50.80 (G3DSA:3.40.50.80)
PS51257 (PROKAR_LIP...)

1 - 26

PROSITE profiles
PS51257 (PROKAR_LIPOPROTEIN)
SFLDG01169 (NADPH_o...)

77 - 1,499

SFLD
SFLDG01169 (NADPH_oxidase_subgroup_(NOX))
SFLDS00052 (Ferric_...)

992 - 1,488

SFLD
SFLDS00052 (Ferric_Reductase_Domain)
SSF52343 (Ferredoxi...)

1,328 - 1,486

SUPERFAMILY
SSF52343 (Ferredoxin reductase-like, C-terminal NADP-linked domain)
cd06186 (NOX_Duox_l...)

1,227 - 1,405

CDD
cd06186 (NOX_Duox_like_FAD_NADP)
cd09820 (dual_perox...)

39 - 590

CDD
cd09820 (dual_peroxidase_like)

Residue annotation

putative heme bind...

246Q

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

247N

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

329V

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

332F

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

333R

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

334F

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

336H

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

339V

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

368W

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

418L

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

421L

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)

425R

putative heme binding site
246Q, 247N, 329V, 332F, 333R, 334F, 336H, 339V, 368W, 418L, 421L, 425R
CDD
cd09820 (dual_peroxidase_like)
putative substrate...

297L

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

300Y

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

301V

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

305L

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

328A

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

332F

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

334F

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

492P

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

496F

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

500I

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

501I

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

504F

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

505T

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)

508R

putative substrate binding site
297L, 300Y, 301V, 305L, 328A, 332F, 334F, 492P, 496F, 500I, 501I, 504F, 505T, 508R
CDD
cd09820 (dual_peroxidase_like)
Ca2+ binding site ...

831D

Ca2+ binding site
831D, 833D, 835D, 842E, 867D, 869D, 871N, 878E
CDD
cd00051 (EFh)

833D

Ca2+ binding site
831D, 833D, 835D, 842E, 867D, 869D, 871N, 878E
CDD
cd00051 (EFh)

835D

Ca2+ binding site
831D, 833D, 835D, 842E, 867D, 869D, 871N, 878E
CDD
cd00051 (EFh)

842E

Ca2+ binding site
831D, 833D, 835D, 842E, 867D, 869D, 871N, 878E
CDD
cd00051 (EFh)

867D

Ca2+ binding site
831D, 833D, 835D, 842E, 867D, 869D, 871N, 878E
CDD
cd00051 (EFh)

869D

Ca2+ binding site
831D, 833D, 835D, 842E, 867D, 869D, 871N, 878E
CDD
cd00051 (EFh)

871N

Ca2+ binding site
831D, 833D, 835D, 842E, 867D, 869D, 871N, 878E
CDD
cd00051 (EFh)

878E

Ca2+ binding site
831D, 833D, 835D, 842E, 867D, 869D, 871N, 878E
CDD
cd00051 (EFh)
FAD binding pocket...

1,251W

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,265H

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,266S

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,267F

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,268T

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,281H

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,282I

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,283K

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,286G

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,287P

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,288W

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,289T

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,335I

FAD binding pocket
1,251W, 1,265H, 1,266S, 1,267F, 1,268T, 1,281H, 1,282I, 1,283K, 1,286G, 1,287P, 1,288W, 1,289T, 1,335I
CDD
cd06186 (NOX_Duox_like_FAD_NADP)
FAD binding motif ...

1,265H

FAD binding motif
1,265H, 1,267F, 1,268T
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,267F

FAD binding motif
1,265H, 1,267F, 1,268T
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,268T

FAD binding motif
1,265H, 1,267F, 1,268T
CDD
cd06186 (NOX_Duox_like_FAD_NADP)
beta-alpha-beta st...

1,330M

beta-alpha-beta stucture motif
1,330M, 1,334G, 1,335I, 1,336G, 1,337V, 1,339P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,334G

beta-alpha-beta stucture motif
1,330M, 1,334G, 1,335I, 1,336G, 1,337V, 1,339P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,335I

beta-alpha-beta stucture motif
1,330M, 1,334G, 1,335I, 1,336G, 1,337V, 1,339P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,336G

beta-alpha-beta stucture motif
1,330M, 1,334G, 1,335I, 1,336G, 1,337V, 1,339P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,337V

beta-alpha-beta stucture motif
1,330M, 1,334G, 1,335I, 1,336G, 1,337V, 1,339P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,339P

beta-alpha-beta stucture motif
1,330M, 1,334G, 1,335I, 1,336G, 1,337V, 1,339P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)
NAD pyrophosphate ...

1,330M

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,331V

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,332G

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,333G

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,334G

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,335I

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,336G

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,337V

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,338T

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,339P

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,340Y

NAD pyrophosphate binding region
1,330M, 1,331V, 1,332G, 1,333G, 1,334G, 1,335I, 1,336G, 1,337V, 1,338T, 1,339P, 1,340Y
CDD
cd06186 (NOX_Duox_like_FAD_NADP)
NAD binding pocket...

1,335I

NAD binding pocket
1,335I, 1,336G, 1,369I, 1,370C, 1,371P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,336G

NAD binding pocket
1,335I, 1,336G, 1,369I, 1,370C, 1,371P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,369I

NAD binding pocket
1,335I, 1,336G, 1,369I, 1,370C, 1,371P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,370C

NAD binding pocket
1,335I, 1,336G, 1,369I, 1,370C, 1,371P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,371P

NAD binding pocket
1,335I, 1,336G, 1,369I, 1,370C, 1,371P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)
NADP ribose bindin...

1,367L

NADP ribose binding motif
1,367L, 1,368W, 1,371P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,368W

NADP ribose binding motif
1,367L, 1,368W, 1,371P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

1,371P

NADP ribose binding motif
1,367L, 1,368W, 1,371P
CDD
cd06186 (NOX_Duox_like_FAD_NADP)

GO term prediction

Biological Process

GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features