KWMTBOMO04076

Protein

Length

256 amino acids

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
3 - 250
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 256

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PF00106 (adh_short)
  
  7 - 206
  
  Pfam
  PF00106 (adh_short)
2. PR00080 (SDRFAMILY)
  
  162 - 181
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  77 - 88
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  142 - 150
  
  PRINTS
  PR00080 (SDRFAMILY)
3. PR00081 (GDHRDH)
  
  183 - 200
  
  PRINTS
  PR00081 (GDHRDH)
  
  6 - 23
  
  PRINTS
  PR00081 (GDHRDH)
  
  77 - 88
  
  PRINTS
  PR00081 (GDHRDH)
  
  136 - 152
  
  PRINTS
  PR00081 (GDHRDH)
  
  162 - 181
  
  PRINTS
  PR00081 (GDHRDH)
  
  217 - 237
  
  PRINTS
  PR00081 (GDHRDH)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  3 - 250
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  3 - 250
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

no IPR

Unintegrated signatures

SM00822 (PKS_KR)

5 - 197

SMART
SM00822 (PKS_KR)
cd05371 (HSD10-like...)

3 - 252

CDD
cd05371 (HSD10-like_SDR_c)

Residue annotation

NAD binding site c...

11G

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

14S

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

15G

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

16L

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

35D

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

36I

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

57G

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

58S

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

59I

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

85C

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

86A

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

87G

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

114I

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

147T

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

148A

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

149S

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

162Y

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

166T

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

192P

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

193G

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

194I

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

195F

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

197T

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

198P

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

199L

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)

200T

NAD binding site
11G, 14S, 15G, 16L, 35D, 36I, 57G, 58S, 59I, 85C, 86A, 87G, 114I, 147T, 148A, 149S, 162Y, 166T, 192P, 193G, 194I, 195F, 197T, 198P, 199L, 200T
CDD
cd05371 (HSD10-like_SDR_c)
homodimer interfac...

93Q

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

94I

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

95Y

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

102P

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

103S

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

105L

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

108F

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

112I

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

117V

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

120F

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

121N

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

124R

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

152A

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

153Y

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

154E

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

155G

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

156D

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

157I

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

158G

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

160A

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

163A

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

164A

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

167A

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

168A

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

171G

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

172M

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

175P

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

176I

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

178R

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)

179D

homodimer interface
93Q, 94I, 95Y, 102P, 103S, 105L, 108F, 112I, 117V, 120F, 121N, 124R, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 175P, 176I, 178R, 179D
CDD
cd05371 (HSD10-like_SDR_c)
homotetramer inter...

93Q

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

94I

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

95Y

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

97F

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

102P

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

103S

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

105L

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

108F

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

109T

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

112I

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

116T

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

117V

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

120F

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

121N

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

124R

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

127A

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

128G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

131G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

138N

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

139G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

140Q

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

152A

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

153Y

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

154E

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

155G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

156D

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

157I

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

158G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

160A

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

163A

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

164A

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

167A

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

168A

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

171G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

172M

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

174L

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

175P

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

176I

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

178R

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

179D

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

181A

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

182S

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

183K

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

184G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

186R

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

195F

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

216P

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

217F

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

218P

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

220R

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

221L

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

222G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

226E

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

229H

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

230L

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

233T

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

235V

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

236E

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

237N

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

238P

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

239M

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

240L

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

241N

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

242G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

243E

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

244V

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

245I

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

246R

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

247L

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

248D

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

249G

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

250A

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)

252R

homotetramer interface
93Q, 94I, 95Y, 97F, 102P, 103S, 105L, 108F, 109T, 112I, 116T, 117V, 120F, 121N, 124R, 127A, 128G, 131G, 138N, 139G, 140Q, 152A, 153Y, 154E, 155G, 156D, 157I, 158G, 160A, 163A, 164A, 167A, 168A, 171G, 172M, 174L, 175P, 176I, 178R, 179D, 181A, 182S, 183K, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229H, 230L, 233T, 235V, 236E, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244V, 245I, 246R, 247L, 248D, 249G, 250A, 252R
CDD
cd05371 (HSD10-like_SDR_c)
active site cd05371

115N

active site
115N, 149S, 162Y, 166T
CDD
cd05371 (HSD10-like_SDR_c)

149S

active site
115N, 149S, 162Y, 166T
CDD
cd05371 (HSD10-like_SDR_c)

162Y

active site
115N, 149S, 162Y, 166T
CDD
cd05371 (HSD10-like_SDR_c)

166T

active site
115N, 149S, 162Y, 166T
CDD
cd05371 (HSD10-like_SDR_c)

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO04076

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component