KWMTBOMO04068

Protein

Length

1,429 amino acids

Protein family membership

Adenylyl cyclase class-4/guanylyl cyclase (IPR001170)

Domains and repeats

Domain
220 - 651
Periplasmic binding protein-like I (IPR028082)
Receptor, ligand binding region (IPR001828)
704 - 1,006
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)
Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)
1,034 - 1,249
Nucleotide cyclase (IPR029787)
Adenylyl cyclase class-3/4/guanylyl cyclase (IPR001054)

1 200 400 600 800 1000 1200 1429

Detailed signature matches

IPR001170

Adenylyl cyclase class-4/guanylyl cyclase
1. PR00255 (NATPEPTIDER)
  
  428 - 446
  
  PRINTS
  PR00255 (NATPEPTIDER)
  
  294 - 312
  
  PRINTS
  PR00255 (NATPEPTIDER)
  
  542 - 560
  
  PRINTS
  PR00255 (NATPEPTIDER)
  
  666 - 688
  
  PRINTS
  PR00255 (NATPEPTIDER)
IPR028082

Periplasmic binding protein-like I
1. SSF53822 (Periplasm...)
  
  220 - 651
  
  SUPERFAMILY
  SSF53822 (Periplasmic binding protein-like I)
IPR001828

Receptor, ligand binding region
1. PF01094 (ANF_receptor)
  
  244 - 608
  
  Pfam
  PF01094 (ANF_receptor)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  751 - 1,006
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  704 - 997
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
IPR001245

Serine-threonine/tyrosine-protein kinase catalytic domain
1. PF07714 (Pkinase_Tyr)
  
  753 - 991
  
  Pfam
  PF07714 (Pkinase_Tyr)
IPR029787

Nucleotide cyclase
1. SSF55073 (Nucleotid...)
  
  1,056 - 1,246
  
  SUPERFAMILY
  SSF55073 (Nucleotide cyclase)
IPR001054

Adenylyl cyclase class-3/4/guanylyl cyclase
1. PS50125 (GUANYLATE_...)
  
  1,070 - 1,200
  
  PROSITE profiles
  PS50125 (GUANYLATE_CYCLASE_2)
2. SM00044 (cyc_6)
  
  1,034 - 1,228
  
  SMART
  SM00044 (cyc_6)
3. G3DSA:3.30.70...
  
  1,055 - 1,249
  
  GENE3D
  G3DSA:3.30.70.1230 (G3DSA:3.30.70.1230)
4. PF00211 (Guanylate_cyc)
  
  1,062 - 1,246
  
  Pfam
  PF00211 (Guanylate_cyc)
IPR018297

Adenylyl cyclase class-4/guanylyl cyclase, conserved site
1. PS00452 (GUANYLATE_...)
  
  1,177 - 1,200
  
  PROSITE patterns
  PS00452 (GUANYLATE_CYCLASE_1)

no IPR

Unintegrated signatures

Coil

1,007 - 1,027

COILS
Coil (Coil)
G3DSA:1.10.51...

794 - 989

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

749 - 793

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
G3DSA:3.40.50...

217 - 341

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)

507 - 596

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)

597 - 651

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)

342 - 503

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
cd06373 (PBP1_NPR_like)

222 - 628

CDD
cd06373 (PBP1_NPR_like)
cd07302 (CHD)

1,068 - 1,245

CDD
cd07302 (CHD)
cd14042 (PK_GC-A_B)

721 - 999

CDD
cd14042 (PK_GC-A_B)
mobidb-lite (disord...)

1,321 - 1,342

MobiDB Lite
mobidb-lite (disorder_prediction)

1,253 - 1,305

MobiDB Lite
mobidb-lite (disorder_prediction)

1,380 - 1,429

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

chloride binding s...

270T

chloride binding site
270T, 297G, 298C
CDD
cd06373 (PBP1_NPR_like)

297G

chloride binding site
270T, 297G, 298C
CDD
cd06373 (PBP1_NPR_like)

298C

chloride binding site
270T, 297G, 298C
CDD
cd06373 (PBP1_NPR_like)
dimerization inter...

279L

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

283E

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

299E

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

300Y

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

303A

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

307R

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

311P

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

312W

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

381F

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

382L

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

385S

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)

388F

dimerization interface (closed form)
279L, 283E, 299E, 300Y, 303A, 307R, 311P, 312W, 381F, 382L, 385S, 388F
CDD
cd06373 (PBP1_NPR_like)
ligand binding sit...

299E

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

300Y

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

303A

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

307R

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

325A

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

326F

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

370D

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

381F

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

382L

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

385S

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

388F

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

389T

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)

403T

ligand binding site
299E, 300Y, 303A, 307R, 325A, 326F, 370D, 381F, 382L, 385S, 388F, 389T, 403T
CDD
cd06373 (PBP1_NPR_like)
dimerization inter...

420L

dimerization interface (open form)
420L, 421H, 441E, 448D
CDD
cd06373 (PBP1_NPR_like)

421H

dimerization interface (open form)
420L, 421H, 441E, 448D
CDD
cd06373 (PBP1_NPR_like)

441E

dimerization interface (open form)
420L, 421H, 441E, 448D
CDD
cd06373 (PBP1_NPR_like)

448D

dimerization interface (open form)
420L, 421H, 441E, 448D
CDD
cd06373 (PBP1_NPR_like)
nucleotidyl bindin...

1,073F

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,075D

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,076I

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,077V

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,078G

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,079F

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,080T

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,115E

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,117I

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,118G

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,119D

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,122M

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,187C

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,188L

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,189F

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,193V

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,194N

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,197S

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,198R

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)

1,235K

nucleotidyl binding site
1,073F, 1,075D, 1,076I, 1,077V, 1,078G, 1,079F, 1,080T, 1,115E, 1,117I, 1,118G, 1,119D, 1,122M, 1,187C, 1,188L, 1,189F, 1,193V, 1,194N, 1,197S, 1,198R, 1,235K
CDD
cd07302 (CHD)
metal binding site...

1,075D

metal binding site
1,075D, 1,119D
CDD
cd07302 (CHD)

1,119D

metal binding site
1,075D, 1,119D
CDD
cd07302 (CHD)
dimer interface cd...

1,080T

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,092V

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,095L

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,096N

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,099Y

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,103D

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,115E

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,116T

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,175V

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,178V

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,188L

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,189F

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,190G

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,191D

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,194N

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

1,235K

dimer interface
1,080T, 1,092V, 1,095L, 1,096N, 1,099Y, 1,103D, 1,115E, 1,116T, 1,175V, 1,178V, 1,188L, 1,189F, 1,190G, 1,191D, 1,194N, 1,235K
CDD
cd07302 (CHD)

GO term prediction

Biological Process

GO:0006468 protein phosphorylation
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0016849 phosphorus-oxygen lyase activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features