KWMTBOMO03235

Protein

Length

2,945 amino acids

Protein family membership

Mini-chromosome maintenance protein (IPR031327)

DNA replication licensing factor Mcm3 (IPR008046)

Domains and repeats

Domain
365 - 435
Pre-C2HC domain (IPR006579)
628 - 832
Endonuclease/exonuclease/phosphatase (IPR005135)
1,095 - 1,383
Reverse transcriptase domain (IPR000477)
1,819 - 1,974
Ribonuclease H-like domain (IPR012337)
Integrase, catalytic core (IPR001584)
2,159 - 2,245
MCM N-terminal domain (IPR027925)
2,256 - 2,386
MCM OB domain (IPR033762)
2,428 - 2,808
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
AAA+ ATPase domain (IPR003593)
MCM domain (IPR001208)
Domain
2,158 - 2,406
Nucleic acid-binding, OB-fold (IPR012340)

1 500 1000 1500 2000 2500 2945

Detailed signature matches

IPR031327

Mini-chromosome maintenance protein
1. SM00350 (mcm)
  
  2,251 - 2,797
  
  SMART
  SM00350 (mcm)
IPR008046

DNA replication licensing factor Mcm3
1. PR01659 (MCMPROTEIN3)
  
  2,639 - 2,649
  
  PRINTS
  PR01659 (MCMPROTEIN3)
  
  2,606 - 2,616
  
  PRINTS
  PR01659 (MCMPROTEIN3)
  
  2,328 - 2,342
  
  PRINTS
  PR01659 (MCMPROTEIN3)
  
  2,354 - 2,366
  
  PRINTS
  PR01659 (MCMPROTEIN3)
  
  2,784 - 2,799
  
  PRINTS
  PR01659 (MCMPROTEIN3)
IPR006579

Pre-C2HC domain
1. PF07530 (PRE_C2HC)
  
  366 - 434
  
  Pfam
  PF07530 (PRE_C2HC)
2. SM00596 (115neu5)
  
  365 - 435
  
  SMART
  SM00596 (115neu5)
IPR005135

Endonuclease/exonuclease/phosphatase
1. PF14529 (Exo_endo_p...)
  
  715 - 827
  
  Pfam
  PF14529 (Exo_endo_phos_2)
2. G3DSA:3.60.10.10
  
  630 - 832
  
  GENE3D
  G3DSA:3.60.10.10 (G3DSA:3.60.10.10)
3. SSF56219 (DNase I-like)
  
  628 - 832
  
  SUPERFAMILY
  SSF56219 (DNase I-like)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  1,120 - 1,383
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  1,095 - 1,383
  
  PROSITE profiles
  PS50878 (RT_POL)
IPR012337

Ribonuclease H-like domain
1. G3DSA:3.30.42...
  
  1,823 - 1,965
  
  GENE3D
  G3DSA:3.30.420.10 (G3DSA:3.30.420.10)
2. SSF53098 (Ribonucle...)
  
  1,827 - 1,974
  
  SUPERFAMILY
  SSF53098 (Ribonuclease H-like)
IPR001584

Integrase, catalytic core
1. PS50994 (INTEGRASE)
  
  1,819 - 1,972
  
  PROSITE profiles
  PS50994 (INTEGRASE)
2. PF00665 (rve)
  
  1,828 - 1,932
  
  Pfam
  PF00665 (rve)
IPR012340

Nucleic acid-binding, OB-fold
1. SSF50249 (Nucleic a...)
  
  2,158 - 2,406
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
IPR027925

MCM N-terminal domain
1. PF14551 (MCM_N)
  
  2,159 - 2,245
  
  Pfam
  PF14551 (MCM_N)
IPR033762

MCM OB domain
1. PF17207 (MCM_OB)
  
  2,256 - 2,386
  
  Pfam
  PF17207 (MCM_OB)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  2,447 - 2,648
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  2,696 - 2,808
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
2. G3DSA:3.40.50...
  
  2,446 - 2,626
  
  GENE3D
  G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
IPR001208

MCM domain
1. PS50051 (MCM_2)
  
  2,437 - 2,643
  
  PROSITE profiles
  PS50051 (MCM_2)
2. PF00493 (MCM)
  
  2,428 - 2,793
  
  Pfam
  PF00493 (MCM)
3. PR01657 (MCMFAMILY)
  
  2,617 - 2,625
  
  PRINTS
  PR01657 (MCMFAMILY)
  
  2,538 - 2,552
  
  PRINTS
  PR01657 (MCMFAMILY)
  
  2,590 - 2,602
  
  PRINTS
  PR01657 (MCMFAMILY)
  
  2,566 - 2,579
  
  PRINTS
  PR01657 (MCMFAMILY)
  
  2,478 - 2,493
  
  PRINTS
  PR01657 (MCMFAMILY)
IPR003593

AAA+ ATPase domain
1. SM00382 (AAA_5)
  
  2,479 - 2,631
  
  SMART
  SM00382 (AAA_5)
IPR018525

Mini-chromosome maintenance, conserved site
1. PS00847 (MCM_1)
  
  2,546 - 2,554
  
  PROSITE patterns
  PS00847 (MCM_1)

no IPR

Unintegrated signatures

G3DSA:2.40.50...

2,254 - 2,281

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)

2,337 - 2,408

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
G3DSA:3.30.16...

2,152 - 2,238

GENE3D
G3DSA:3.30.1640.10 (G3DSA:3.30.1640.10)
SSF56672 (DNA/RNA p...)

1,539 - 1,651

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)

1,008 - 1,336

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00009 (AAA)

2,482 - 2,627

CDD
cd00009 (AAA)
cd01650 (RT_nLTR_like)

1,111 - 1,383

CDD
cd01650 (RT_nLTR_like)
cd09274 (RNase_HI_R...)

1,543 - 1,666

CDD
cd09274 (RNase_HI_RT_Ty3)
mobidb-lite (disord...)

495 - 523

MobiDB Lite
mobidb-lite (disorder_prediction)

548 - 572

MobiDB Lite
mobidb-lite (disorder_prediction)

2,096 - 2,130

MobiDB Lite
mobidb-lite (disorder_prediction)

2,037 - 2,080

MobiDB Lite
mobidb-lite (disorder_prediction)

1,017 - 1,051

MobiDB Lite
mobidb-lite (disorder_prediction)

2,805 - 2,874

MobiDB Lite
mobidb-lite (disorder_prediction)

174 - 281

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative NTP bindi...

1,200D

putative NTP binding site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,288D
CDD
cd01650 (RT_nLTR_like)

1,201I

putative NTP binding site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,288D
CDD
cd01650 (RT_nLTR_like)

1,202A

putative NTP binding site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,288D
CDD
cd01650 (RT_nLTR_like)

1,203K

putative NTP binding site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,288D
CDD
cd01650 (RT_nLTR_like)

1,204A

putative NTP binding site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,288D
CDD
cd01650 (RT_nLTR_like)

1,205F

putative NTP binding site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,288D
CDD
cd01650 (RT_nLTR_like)

1,259Q

putative NTP binding site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,288D
CDD
cd01650 (RT_nLTR_like)

1,288D

putative NTP binding site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,288D
CDD
cd01650 (RT_nLTR_like)
putative active si...

1,200D

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,201I

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,202A

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,203K

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,204A

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,205F

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,259Q

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,260G

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,286F

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,288D

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,289D

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,379L

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)

1,380G

putative active site
1,200D, 1,201I, 1,202A, 1,203K, 1,204A, 1,205F, 1,259Q, 1,260G, 1,286F, 1,288D, 1,289D, 1,379L, 1,380G
CDD
cd01650 (RT_nLTR_like)
putative nucleic a...

1,260G

putative nucleic acid binding site
1,260G
CDD
cd01650 (RT_nLTR_like)
active site cd09274

1,546D

active site
1,546D, 1,587E, 1,612D, 1,660D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,587E

active site
1,546D, 1,587E, 1,612D, 1,660D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,612D

active site
1,546D, 1,587E, 1,612D, 1,660D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,660D

active site
1,546D, 1,587E, 1,612D, 1,660D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

1,546D

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,547A

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,548S

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,549D

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,582S

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,583V

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,584I

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,587E

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,612D

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,650Y

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,664R

RNA/DNA hybrid binding site
1,546D, 1,547A, 1,548S, 1,549D, 1,582S, 1,583V, 1,584I, 1,587E, 1,612D, 1,650Y, 1,664R
CDD
cd09274 (RNase_HI_RT_Ty3)
Walker A motif cd0...

2,487G

Walker A motif
2,487G, 2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S
CDD
cd00009 (AAA)

2,488D

Walker A motif
2,487G, 2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S
CDD
cd00009 (AAA)

2,489P

Walker A motif
2,487G, 2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S
CDD
cd00009 (AAA)

2,490S

Walker A motif
2,487G, 2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S
CDD
cd00009 (AAA)

2,491V

Walker A motif
2,487G, 2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S
CDD
cd00009 (AAA)

2,492A

Walker A motif
2,487G, 2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S
CDD
cd00009 (AAA)

2,493K

Walker A motif
2,487G, 2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S
CDD
cd00009 (AAA)

2,494S

Walker A motif
2,487G, 2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S
CDD
cd00009 (AAA)
ATP binding site c...

2,488D

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)

2,489P

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)

2,490S

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)

2,491V

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)

2,492A

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)

2,493K

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)

2,494S

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)

2,495Q

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)

2,551D

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)

2,595N

ATP binding site
2,488D, 2,489P, 2,490S, 2,491V, 2,492A, 2,493K, 2,494S, 2,495Q, 2,551D, 2,595N
CDD
cd00009 (AAA)
Walker B motif cd0...

2,547V

Walker B motif
2,547V, 2,548V, 2,549C, 2,550I, 2,551D, 2,552E
CDD
cd00009 (AAA)

2,548V

Walker B motif
2,547V, 2,548V, 2,549C, 2,550I, 2,551D, 2,552E
CDD
cd00009 (AAA)

2,549C

Walker B motif
2,547V, 2,548V, 2,549C, 2,550I, 2,551D, 2,552E
CDD
cd00009 (AAA)

2,550I

Walker B motif
2,547V, 2,548V, 2,549C, 2,550I, 2,551D, 2,552E
CDD
cd00009 (AAA)

2,551D

Walker B motif
2,547V, 2,548V, 2,549C, 2,550I, 2,551D, 2,552E
CDD
cd00009 (AAA)

2,552E

Walker B motif
2,547V, 2,548V, 2,549C, 2,550I, 2,551D, 2,552E
CDD
cd00009 (AAA)
arginine finger cd...

2,620R

arginine finger
2,620R
CDD
cd00009 (AAA)

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0015074 DNA integration

Molecular Function

GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0005524 ATP binding

Cellular Component

GO:0005634 nucleus
GO:0042555 MCM complex

Filter view on

Entry type

Status

Per-residue features