KWMTBOMO03007

Protein

Length

490 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
7 - 308
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)
391 - 422
Serine/threonine-protein kinase OSR1/WNK, CCT domain (IPR024678)

1 50 100 150 200 250 300 350 400 450 490

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  7 - 308
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. SM00220 (serkin_6)
  
  15 - 289
  
  SMART
  SM00220 (serkin_6)
2. PS50011 (PROTEIN_KI...)
  
  15 - 289
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
3. PF00069 (Pkinase)
  
  15 - 289
  
  Pfam
  PF00069 (Pkinase)
IPR024678

Serine/threonine-protein kinase OSR1/WNK, CCT domain
1. PF12202 (OSR1_C)
  
  391 - 422
  
  Pfam
  PF12202 (OSR1_C)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  21 - 44
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)

no IPR

Unintegrated signatures

G3DSA:1.10.51...

78 - 296

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.10.20.90

390 - 488

GENE3D
G3DSA:3.10.20.90 (G3DSA:3.10.20.90)
G3DSA:3.30.20...

11 - 77

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd06610 (STKc_OSR1_...)

13 - 289

CDD
cd06610 (STKc_OSR1_SPAK)
mobidb-lite (disord...)

309 - 383

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

21I

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

22G

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

23V

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

24G

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

25A

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

29V

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

42A

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

44K

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

74V

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

90L

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

91R

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

92L

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

93L

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

96G

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

97S

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

100D

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

146K

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

148G

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

149N

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

151L

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)

162D

ATP binding site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 146K, 148G, 149N, 151L, 162D
CDD
cd06610 (STKc_OSR1_SPAK)
active site cd06610

21I

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

22G

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

23V

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

24G

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

25A

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

29V

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

42A

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

44K

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

74V

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

90L

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

91R

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

92L

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

93L

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

96G

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

97S

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

100D

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

144D

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

146K

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

147A

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

148G

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

149N

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

151L

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

161A

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

162D

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

165V

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

184F

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

185V

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

186G

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

187T

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

189C

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

217E

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

226H

active site
21I, 22G, 23V, 24G, 25A, 29V, 42A, 44K, 74V, 90L, 91R, 92L, 93L, 96G, 97S, 100D, 144D, 146K, 147A, 148G, 149N, 151L, 161A, 162D, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)
polypeptide substr...

24G

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

25A

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

144D

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

146K

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

147A

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

148G

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

165V

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

184F

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

185V

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

186G

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

187T

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

189C

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

217E

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)

226H

polypeptide substrate binding site
24G, 25A, 144D, 146K, 147A, 148G, 165V, 184F, 185V, 186G, 187T, 189C, 217E, 226H
CDD
cd06610 (STKc_OSR1_SPAK)
dimer interface cd...

145I

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

146K

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

170A

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

171T

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

172G

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

185V

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

186G

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

187T

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

188P

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

189C

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

190W

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

191M

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

192A

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

193P

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

194E

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

195V

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

196M

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

197E

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

198Q

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

200H

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

201G

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

202Y

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

206A

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

209W

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

210S

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

213I

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

214T

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

217E

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

223A

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

230P

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

233V

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

234L

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

235M

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

237T

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

238L

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

272K

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

274P

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

275T

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)

277R

dimer interface
145I, 146K, 170A, 171T, 172G, 185V, 186G, 187T, 188P, 189C, 190W, 191M, 192A, 193P, 194E, 195V, 196M, 197E, 198Q, 200H, 201G, 202Y, 206A, 209W, 210S, 213I, 214T, 217E, 223A, 230P, 233V, 234L, 235M, 237T, 238L, 272K, 274P, 275T, 277R
CDD
cd06610 (STKc_OSR1_SPAK)
activation loop (A...

161A

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

162D

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

163F

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

164G

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

165V

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

166S

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

167A

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

168W

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

169L

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

170A

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

171T

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

172G

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

173R

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

174D

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

181R

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

182H

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

183T

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

184F

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

185V

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

186G

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

187T

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

188P

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

189C

activation loop (A-loop)
161A, 162D, 163F, 164G, 165V, 166S, 167A, 168W, 169L, 170A, 171T, 172G, 173R, 174D, 181R, 182H, 183T, 184F, 185V, 186G, 187T, 188P, 189C
CDD
cd06610 (STKc_OSR1_SPAK)

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component