KWMTBOMO02932

Protein

Length

1,650 amino acids

Protein family membership

DNA ligase, ATP-dependent (IPR000977)

Domains and repeats

Domain
70 - 501
Tetratricopeptide-like helical domain (IPR011990)
645 - 679
Tetratricopeptide-like helical domain (IPR011990)
708 - 748
Tetratricopeptide-like helical domain (IPR011990)
995 - 1,245
DNA ligase, ATP-dependent, central (IPR012310)
Domain
137 - 170
Tetratricopeptide repeat-containing domain (IPR013026)
352 - 454
Tetratricopeptide repeat-containing domain (IPR013026)
719 - 752
Tetratricopeptide repeat-containing domain (IPR013026)
756 - 986
DNA ligase, ATP-dependent, N-terminal (IPR012308)
1,217 - 1,360
Nucleic acid-binding, OB-fold (IPR012340)
DNA ligase, ATP-dependent, C-terminal (IPR012309)
1,402 - 1,488
BRCT domain (IPR001357)
1,564 - 1,650
BRCT domain (IPR001357)
Repeat
71 - 104
Tetratricopeptide repeat (IPR019734)
137 - 170
Tetratricopeptide repeat (IPR019734)
387 - 420
Tetratricopeptide repeat (IPR019734)
719 - 752
Tetratricopeptide repeat (IPR019734)

1 200 400 600 800 1000 1200 1400 1650

Detailed signature matches

IPR000977

DNA ligase, ATP-dependent
1. TIGR00574
  
  830 - 1,358
  
  TIGRFAMs
  TIGR00574 (TIGR00574)
IPR011990

Tetratricopeptide-like helical domain
1. SSF48452 (TPR-like)
  
  135 - 449
  
  SUPERFAMILY
  SSF48452 (TPR-like)
  
  72 - 170
  
  SUPERFAMILY
  SSF48452 (TPR-like)
  
  387 - 447
  
  SUPERFAMILY
  SSF48452 (TPR-like)
  
  708 - 748
  
  SUPERFAMILY
  SSF48452 (TPR-like)
  
  645 - 679
  
  SUPERFAMILY
  SSF48452 (TPR-like)
2. G3DSA:1.25.40.10
  
  716 - 748
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
  
  354 - 501
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
  
  70 - 187
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
IPR013026

Tetratricopeptide repeat-containing domain
1. PS50293 (TPR_REGION)
  
  719 - 752
  
  PROSITE profiles
  PS50293 (TPR_REGION)
  
  352 - 454
  
  PROSITE profiles
  PS50293 (TPR_REGION)
  
  137 - 170
  
  PROSITE profiles
  PS50293 (TPR_REGION)
IPR012308

DNA ligase, ATP-dependent, N-terminal
1. G3DSA:1.10.32...
  
  756 - 954
  
  GENE3D
  G3DSA:1.10.3260.10 (G3DSA:1.10.3260.10)
2. PF04675 (DNA_ligase...)
  
  767 - 955
  
  Pfam
  PF04675 (DNA_ligase_A_N)
3. SSF117018 (ATP-depe...)
  
  758 - 986
  
  SUPERFAMILY
  SSF117018 (ATP-dependent DNA ligase DNA-binding domain)
IPR012310

DNA ligase, ATP-dependent, central
1. PF01068 (DNA_ligase...)
  
  995 - 1,207
  
  Pfam
  PF01068 (DNA_ligase_A_M)
2. PS50160 (DNA_LIGASE_A3)
  
  1,105 - 1,245
  
  PROSITE profiles
  PS50160 (DNA_LIGASE_A3)
IPR012340

Nucleic acid-binding, OB-fold
1. SSF50249 (Nucleic a...)
  
  1,217 - 1,360
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
IPR012309

DNA ligase, ATP-dependent, C-terminal
1. PF04679 (DNA_ligase...)
  
  1,234 - 1,343
  
  Pfam
  PF04679 (DNA_ligase_A_C)
IPR001357

BRCT domain
1. SM00292 (BRCT_7)
  
  1,564 - 1,640
  
  SMART
  SM00292 (BRCT_7)
  
  1,411 - 1,488
  
  SMART
  SM00292 (BRCT_7)
2. G3DSA:3.40.50...
  
  1,584 - 1,649
  
  GENE3D
  G3DSA:3.40.50.10190 (G3DSA:3.40.50.10190)
  
  1,411 - 1,486
  
  GENE3D
  G3DSA:3.40.50.10190 (G3DSA:3.40.50.10190)
3. PS50172 (BRCT)
  
  1,584 - 1,650
  
  PROSITE profiles
  PS50172 (BRCT)
4. SSF52113 (BRCT domain)
  
  1,564 - 1,650
  
  SUPERFAMILY
  SSF52113 (BRCT domain)
  
  1,402 - 1,484
  
  SUPERFAMILY
  SSF52113 (BRCT domain)
5. cd00027 (BRCT)
  
  1,416 - 1,484
  
  CDD
  cd00027 (BRCT)
IPR019734

Tetratricopeptide repeat
1. PS50005 (TPR)
  
  137 - 170
  
  PROSITE profiles
  PS50005 (TPR)
  
  719 - 752
  
  PROSITE profiles
  PS50005 (TPR)
  
  387 - 420
  
  PROSITE profiles
  PS50005 (TPR)
2. SM00028 (tpr_5)
  
  719 - 752
  
  SMART
  SM00028 (tpr_5)
  
  71 - 104
  
  SMART
  SM00028 (tpr_5)
  
  137 - 170
  
  SMART
  SM00028 (tpr_5)
  
  387 - 420
  
  SMART
  SM00028 (tpr_5)
IPR016059

DNA ligase, ATP-dependent, conserved site
1. PS00333 (DNA_LIGASE_A2)
  
  1,183 - 1,207
  
  PROSITE patterns
  PS00333 (DNA_LIGASE_A2)

no IPR

Unintegrated signatures

G3DSA:2.40.50...

1,217 - 1,360

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
G3DSA:3.30.14...

1,008 - 1,024

GENE3D
G3DSA:3.30.1490.70 (G3DSA:3.30.1490.70)

1,161 - 1,214

GENE3D
G3DSA:3.30.1490.70 (G3DSA:3.30.1490.70)
G3DSA:3.30.47...

1,025 - 1,155

GENE3D
G3DSA:3.30.470.30 (G3DSA:3.30.470.30)
SSF56091 (DNA ligas...)

951 - 1,208

SUPERFAMILY
SSF56091 (DNA ligase/mRNA capping enzyme, catalytic domain)
cd07903 (Adenylatio...)

983 - 1,212

CDD
cd07903 (Adenylation_DNA_ligase_IV)

Residue annotation

active site cd07903

1,019E

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,020K

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,021K

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,022F

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,024G

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,025E

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,026R

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,041K

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,081E

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,092F

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,117F

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,183E

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,186V

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,188K

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,203W

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,205K

active site
1,019E, 1,020K, 1,021K, 1,022F, 1,024G, 1,025E, 1,026R, 1,041K, 1,081E, 1,092F, 1,117F, 1,183E, 1,186V, 1,188K, 1,203W, 1,205K
CDD
cd07903 (Adenylation_DNA_ligase_IV)
DNA binding site c...

1,021K

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,024G

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,025E

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,026R

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,040S

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,041K

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,042K

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,044H

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,048F

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,096S

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,097M

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,100N

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,101I

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,102K

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,183E

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,205K

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)

1,207K

DNA binding site
1,021K, 1,024G, 1,025E, 1,026R, 1,040S, 1,041K, 1,042K, 1,044H, 1,048F, 1,096S, 1,097M, 1,100N, 1,101I, 1,102K, 1,183E, 1,205K, 1,207K
CDD
cd07903 (Adenylation_DNA_ligase_IV)
Dimer interface cd...

1,431T

Dimer interface
1,431T, 1,435K, 1,438E, 1,441G, 1,443Q
CDD
cd00027 (BRCT)

1,435K

Dimer interface
1,431T, 1,435K, 1,438E, 1,441G, 1,443Q
CDD
cd00027 (BRCT)

1,438E

Dimer interface
1,431T, 1,435K, 1,438E, 1,441G, 1,443Q
CDD
cd00027 (BRCT)

1,441G

Dimer interface
1,431T, 1,435K, 1,438E, 1,441G, 1,443Q
CDD
cd00027 (BRCT)

1,443Q

Dimer interface
1,431T, 1,435K, 1,438E, 1,441G, 1,443Q
CDD
cd00027 (BRCT)
BRCT sequence moti...

1,480W

BRCT sequence motif
1,480W, 1,484L
CDD
cd00027 (BRCT)

1,484L

BRCT sequence motif
1,480W, 1,484L
CDD
cd00027 (BRCT)

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

Molecular Function

GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features