KWMTBOMO02120

Protein

Length

824 amino acids

Protein family membership

Transcription initiation factor IIF, beta subunit (IPR003196)

Domains and repeats

Domain
3 - 120
Transcription Factor IIF, Rap30/Rap74, interaction (IPR011039)
177 - 244
Winged helix-turn-helix DNA-binding domain (IPR011991)
553 - 622
Pre-C2HC domain (IPR006579)

1 100 200 300 400 500 600 700 824

Detailed signature matches

IPR003196

Transcription initiation factor IIF, beta subunit
1. PF02270 (TFIIF_beta)
  
  104 - 241
  
  Pfam
  PF02270 (TFIIF_beta)
  
  3 - 89
  
  Pfam
  PF02270 (TFIIF_beta)
IPR011039

Transcription Factor IIF, Rap30/Rap74, interaction
1. SSF50916 (Rap30/74 ...)
  
  3 - 120
  
  SUPERFAMILY
  SSF50916 (Rap30/74 interaction domains)
IPR011991

Winged helix-turn-helix DNA-binding domain
1. G3DSA:1.10.10.10
  
  177 - 244
  
  GENE3D
  G3DSA:1.10.10.10 (G3DSA:1.10.10.10)
2. SSF46785 ("Winged h...)
  
  177 - 243
  
  SUPERFAMILY
  SSF46785 ("Winged helix" DNA-binding domain)
IPR006579

Pre-C2HC domain
1. PF07530 (PRE_C2HC)
  
  555 - 621
  
  Pfam
  PF07530 (PRE_C2HC)
2. SM00596 (115neu5)
  
  553 - 622
  
  SMART
  SM00596 (115neu5)

no IPR

Unintegrated signatures

cd07980 (TFIIF_beta)

3 - 120

CDD
cd07980 (TFIIF_beta)
mobidb-lite (disord...)

368 - 469

MobiDB Lite
mobidb-lite (disorder_prediction)

742 - 761

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

heterodimer interf...

8N

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

10G

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

13V

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

14W

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

15L

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

16V

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

17K

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

18V

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

19P

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

20K

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

23A

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

26W

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

29A

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

34E

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

35V

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

36G

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

37K

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

38L

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

39K

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

40I

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

41S

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

42R

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

49K

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

82T

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

83Q

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

84S

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

85L

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

86G

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

87V

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

88F

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

89S

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

106L

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

108M

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

109E

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

115K

heterodimer interface
8N, 10G, 13V, 14W, 15L, 16V, 17K, 18V, 19P, 20K, 23A, 26W, 29A, 34E, 35V, 36G, 37K, 38L, 39K, 40I, 41S, 42R, 49K, 82T, 83Q, 84S, 85L, 86G, 87V, 88F, 89S, 106L, 108M, 109E, 115K
CDD
cd07980 (TFIIF_beta)

GO term prediction

Biological Process

GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter

Molecular Function

GO:0003824 catalytic activity

Cellular Component

GO:0005674 transcription factor TFIIF complex

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Entry type

Status

Per-residue features