KWMTBOMO02061

Protein

Length

430 amino acids

Protein family membership

Adenosylhomocysteinase (IPR000043)

Domains and repeats

Domain
190 - 350
S-adenosyl-L-homocysteine hydrolase, NAD binding domain (IPR015878)
Domain
190 - 350
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 350 400 430

Detailed signature matches

IPR000043

Adenosylhomocysteinase
1. TIGR00936
  
  5 - 422
  
  TIGRFAMs
  TIGR00936 (TIGR00936)
2. PF05221 (AdoHcyase)
  
  5 - 140
  
  Pfam
  PF05221 (AdoHcyase)
3. SM00996 (AdoHcyase_2)
  
  4 - 429
  
  SMART
  SM00996 (AdoHcyase_2)
4. MF_00563 (AdoHcyase)
  
  1 - 422
  
  HAMAP
  MF_00563 (AdoHcyase)
5. PIRSF001109 (SAHH)
  
  1 - 430
  
  PIRSF
  PIRSF001109 (SAHH)
6. cd00401 (SAHH)
  
  14 - 417
  
  CDD
  cd00401 (SAHH)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  190 - 350
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  229 - 301
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain
1. SM00997 (AdoHcyase_...)
  
  190 - 350
  
  SMART
  SM00997 (AdoHcyase_NAD_2)
2. PF00670 (AdoHcyase_NAD)
  
  190 - 350
  
  Pfam
  PF00670 (AdoHcyase_NAD)
IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site
1. PS00739 (ADOHCYASE_2)
  
  212 - 228
  
  PROSITE patterns
  PS00739 (ADOHCYASE_2)
2. PS00738 (ADOHCYASE_1)
  
  76 - 90
  
  PROSITE patterns
  PS00738 (ADOHCYASE_1)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

3 - 228

GENE3D
G3DSA:3.40.50.1480 (G3DSA:3.40.50.1480)

319 - 430

GENE3D
G3DSA:3.40.50.1480 (G3DSA:3.40.50.1480)
SSF52283 (Formate/g...)

3 - 189

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)

351 - 430

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)

Residue annotation

homotetramer inter...

15W

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

18K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

22L

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

25K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

26E

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

161H

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

164Y

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

165K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

181D

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

183V

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

187K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

188F

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

192Y

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

195R

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

196E

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

200D

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

203K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

204R

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

207D

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

208I

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

209M

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

210I

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

211A

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

212G

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

213K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

221G

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

222D

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

225K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

234F

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

235G

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

237R

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

242E

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

243I

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

244D

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

245P

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

246I

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

247N

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

248A

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

249L

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

250Q

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

252A

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

253M

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

254E

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

255G

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

257Q

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

258V

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

259T

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

260T

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

263E

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

276G

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

277N

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

278I

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

279D

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

280I

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

290K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

291D

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

292D

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

303C

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

319I

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

320K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

325R

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

349T

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

352S

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

354F

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

355V

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

358N

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

383T

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

389D

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

390E

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

393A

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

394A

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

397L

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

400L

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

401G

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

403K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

404L

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

405T

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

407L

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

410K

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

411Q

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

414Y

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)

415I

homotetramer interface
15W, 18K, 22L, 25K, 26E, 161H, 164Y, 165K, 181D, 183V, 187K, 188F, 192Y, 195R, 196E, 200D, 203K, 204R, 207D, 208I, 209M, 210I, 211A, 212G, 213K, 221G, 222D, 225K, 234F, 235G, 237R, 242E, 243I, 244D, 245P, 246I, 247N, 248A, 249L, 250Q, 252A, 253M, 254E, 255G, 257Q, 258V, 259T, 260T, 263E, 276G, 277N, 278I, 279D, 280I, 290K, 291D, 292D, 303C, 319I, 320K, 325R, 349T, 352S, 354F, 355V, 358N, 383T, 389D, 390E, 393A, 394A, 397L, 400L, 401G, 403K, 404L, 405T, 407L, 410K, 411Q, 414Y, 415I
CDD
cd00401 (SAHH)
catalytic site cd0...

53H

catalytic site
53H, 130D, 155E, 189D
CDD
cd00401 (SAHH)

130D

catalytic site
53H, 130D, 155E, 189D
CDD
cd00401 (SAHH)

155E

catalytic site
53H, 130D, 155E, 189D
CDD
cd00401 (SAHH)

189D

catalytic site
53H, 130D, 155E, 189D
CDD
cd00401 (SAHH)
ligand binding sit...

53H

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

55T

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

57Q

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

58T

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

130D

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

155E

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

156T

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

185K

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

189D

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

345L

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

350G

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

351H

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

356M

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)

360F

ligand binding site
53H, 55T, 57Q, 58T, 130D, 155E, 156T, 185K, 189D, 345L, 350G, 351H, 356M, 360F
CDD
cd00401 (SAHH)
NAD binding site c...

156T

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

157T

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

158T

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

190N

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

194C

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

219G

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

221G

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

222D

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

223V

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

241T

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

242E

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

243I

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

244D

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

247N

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

274T

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

275T

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

276G

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

277N

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

280I

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

298I

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

299G

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

300H

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

342L

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

344N

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

351H

NAD binding site
156T, 157T, 158T, 190N, 194C, 219G, 221G, 222D, 223V, 241T, 242E, 243I, 244D, 247N, 274T, 275T, 276G, 277N, 280I, 298I, 299G, 300H, 342L, 344N, 351H
CDD
cd00401 (SAHH)

GO term prediction

Biological Process

GO:0006730 one-carbon metabolic process
GO:0019510 S-adenosylhomocysteine catabolic process

Molecular Function

GO:0004013 adenosylhomocysteinase activity
GO:0051287 NAD binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features