KWMTBOMO01991

Protein

Length

2,817 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
1 - 155
Telomere-length maintenance and DNA damage repair (IPR021668)
1,756 - 2,348
PIK-related kinase (IPR014009)
2,394 - 2,817
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)
Domain
403 - 614
Armadillo-type fold (IPR016024)
657 - 1,050
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
1,128 - 1,171
Armadillo-like helical (IPR011989)
1,215 - 1,345
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
1,370 - 1,650
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
2,785 - 2,817
FATC domain (IPR003152)

1 500 1000 1500 2000 2500 2817

Detailed signature matches

IPR021668

Telomere-length maintenance and DNA damage repair
1. SM01342 (TAN_2)
  
  1 - 155
  
  SMART
  SM01342 (TAN_2)
2. PF11640 (TAN)
  
  8 - 154
  
  Pfam
  PF11640 (TAN)
IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  657 - 1,050
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  403 - 614
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,241 - 1,328
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,370 - 1,650
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  1,128 - 1,171
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  1,215 - 1,345
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  838 - 961
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  699 - 796
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  1,443 - 1,566
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,756 - 2,348
  
  PROSITE profiles
  PS51189 (FAT)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  2,603 - 2,754
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  2,394 - 2,562
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. G3DSA:1.10.10...
  
  2,534 - 2,549
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
  
  2,610 - 2,807
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
2. SM00146 (pi3k_hr1_6)
  
  2,486 - 2,786
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PS50290 (PI3_4_KINA...)
  
  2,484 - 2,817
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
4. PF00454 (PI3_PI4_ki...)
  
  2,488 - 2,737
  
  Pfam
  PF00454 (PI3_PI4_kinase)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,785 - 2,817
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,789 - 2,817
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,785 - 2,817
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,632 - 2,652
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)
2. PS00915 (PI3_4_KINA...)
  
  2,489 - 2,503
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

2,432 - 2,533

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
cd05171 (PIKKc_ATM)

2,457 - 2,739

CDD
cd05171 (PIKKc_ATM)

Residue annotation

ATP binding site c...

2,466V

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,468G

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,469I

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,470N

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,472P

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,488L

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,490K

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,493D

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,528Y

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,540L

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,541E

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,542W

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,543C

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,548P

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,652N

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,654L

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,665I

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)

2,666D

ATP binding site
2,466V, 2,468G, 2,469I, 2,470N, 2,472P, 2,488L, 2,490K, 2,493D, 2,528Y, 2,540L, 2,541E, 2,542W, 2,543C, 2,548P, 2,652N, 2,654L, 2,665I, 2,666D
CDD
cd05171 (PIKKc_ATM)
catalytic loop cd0...

2,644G

catalytic loop
2,644G, 2,645L, 2,646G, 2,647D, 2,648R, 2,649H, 2,650V, 2,651Q, 2,652N
CDD
cd05171 (PIKKc_ATM)

2,645L

catalytic loop
2,644G, 2,645L, 2,646G, 2,647D, 2,648R, 2,649H, 2,650V, 2,651Q, 2,652N
CDD
cd05171 (PIKKc_ATM)

2,646G

catalytic loop
2,644G, 2,645L, 2,646G, 2,647D, 2,648R, 2,649H, 2,650V, 2,651Q, 2,652N
CDD
cd05171 (PIKKc_ATM)

2,647D

catalytic loop
2,644G, 2,645L, 2,646G, 2,647D, 2,648R, 2,649H, 2,650V, 2,651Q, 2,652N
CDD
cd05171 (PIKKc_ATM)

2,648R

catalytic loop
2,644G, 2,645L, 2,646G, 2,647D, 2,648R, 2,649H, 2,650V, 2,651Q, 2,652N
CDD
cd05171 (PIKKc_ATM)

2,649H

catalytic loop
2,644G, 2,645L, 2,646G, 2,647D, 2,648R, 2,649H, 2,650V, 2,651Q, 2,652N
CDD
cd05171 (PIKKc_ATM)

2,650V

catalytic loop
2,644G, 2,645L, 2,646G, 2,647D, 2,648R, 2,649H, 2,650V, 2,651Q, 2,652N
CDD
cd05171 (PIKKc_ATM)

2,651Q

catalytic loop
2,644G, 2,645L, 2,646G, 2,647D, 2,648R, 2,649H, 2,650V, 2,651Q, 2,652N
CDD
cd05171 (PIKKc_ATM)

2,652N

catalytic loop
2,644G, 2,645L, 2,646G, 2,647D, 2,648R, 2,649H, 2,650V, 2,651Q, 2,652N
CDD
cd05171 (PIKKc_ATM)
activation loop (A...

2,666D

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,667F

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,668G

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,669I

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,670A

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,671F

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,672D

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,673Q

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,674G

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,675K

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,676A

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,677L

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,678T

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,679T

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,680P

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,681E

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,682T

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,683V

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,684P

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,685F

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,686R

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,687L

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

2,688T

activation loop (A-loop)
2,666D, 2,667F, 2,668G, 2,669I, 2,670A, 2,671F, 2,672D, 2,673Q, 2,674G, 2,675K, 2,676A, 2,677L, 2,678T, 2,679T, 2,680P, 2,681E, 2,682T, 2,683V, 2,684P, 2,685F, 2,686R, 2,687L, 2,688T
CDD
cd05171 (PIKKc_ATM)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0016301 kinase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

KWMTBOMO01991

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component