KWMTBOMO01437

Protein

Length

2,418 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
4 - 284
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
341 - 496
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
603 - 1,178
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
1,221 - 1,455
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
1,819 - 1,906
Armadillo-like helical (IPR011989)
2,361 - 2,382
Armadillo-like helical (IPR011989)
Domain
800 - 969
Domain of unknown function DUF3385, target of rapamycin protein (IPR024585)
1,383 - 1,416
Tetratricopeptide repeat-containing domain (IPR013026)
1,899 - 1,996
FKBP12-rapamycin binding domain (IPR009076)
2,386 - 2,418
FATC domain (IPR003152)
Domain
1,321 - 1,866
PIK-related kinase (IPR014009)
PIK-related kinase, FAT (IPR003151)
1,979 - 2,418
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)
Domain
1,329 - 1,438
Tetratricopeptide-like helical domain (IPR011990)
1,471 - 1,515
Tetratricopeptide-like helical domain (IPR011990)
1,635 - 1,723
Tetratricopeptide-like helical domain (IPR011990)
Repeat
1,383 - 1,416
Tetratricopeptide repeat (IPR019734)

1 500 1000 1500 2000 2418

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  341 - 411
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,221 - 1,455
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  603 - 1,178
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  4 - 284
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  9 - 284
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  644 - 743
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  341 - 496
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  932 - 1,032
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  1,281 - 1,328
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  1,093 - 1,137
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  744 - 846
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  2,361 - 2,382
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  1,819 - 1,906
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR024585

Domain of unknown function DUF3385, target of rapamycin protein
1. PF11865 (DUF3385)
  
  800 - 969
  
  Pfam
  PF11865 (DUF3385)
2. SM01346 (DUF3385_3)
  
  800 - 969
  
  SMART
  SM01346 (DUF3385_3)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,321 - 1,866
  
  PROSITE profiles
  PS51189 (FAT)
IPR011990

Tetratricopeptide-like helical domain
1. G3DSA:1.25.40.10
  
  1,635 - 1,723
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
  
  1,471 - 1,515
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
  
  1,329 - 1,438
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
IPR013026

Tetratricopeptide repeat-containing domain
1. PS50293 (TPR_REGION)
  
  1,383 - 1,416
  
  PROSITE profiles
  PS50293 (TPR_REGION)
IPR003151

PIK-related kinase, FAT
1. PF02259 (FAT)
  
  1,456 - 1,792
  
  Pfam
  PF02259 (FAT)
IPR009076

FKBP12-rapamycin binding domain
1. G3DSA:1.20.12...
  
  1,907 - 1,994
  
  GENE3D
  G3DSA:1.20.120.150 (G3DSA:1.20.120.150)
2. PF08771 (FRB_dom)
  
  1,899 - 1,996
  
  Pfam
  PF08771 (FRB_dom)
3. SSF47212 (FKBP12-ra...)
  
  1,903 - 1,995
  
  SUPERFAMILY
  SSF47212 (FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP))
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  2,180 - 2,320
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  1,979 - 2,143
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. G3DSA:1.10.10...
  
  2,383 - 2,410
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
  
  2,187 - 2,317
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
  
  2,116 - 2,130
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
2. SM00146 (pi3k_hr1_6)
  
  2,067 - 2,371
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  2,066 - 2,316
  
  Pfam
  PF00454 (PI3_PI4_kinase)
4. PS50290 (PI3_4_KINA...)
  
  2,066 - 2,418
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,386 - 2,418
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,389 - 2,418
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,386 - 2,418
  
  PROSITE profiles
  PS51190 (FATC)
IPR019734

Tetratricopeptide repeat
1. PS50005 (TPR)
  
  1,383 - 1,416
  
  PROSITE profiles
  PS50005 (TPR)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,209 - 2,229
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)
2. PS00915 (PI3_4_KINA...)
  
  2,070 - 2,084
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

Coil

1,174 - 1,194

COILS
Coil (Coil)
G3DSA:3.30.10...

1,995 - 2,115

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
SM01345 (Rapamycin_...)

1,899 - 1,998

SMART
SM01345 (Rapamycin_bind_3)
cd05169 (PIKKc_TOR)

2,037 - 2,317

CDD
cd05169 (PIKKc_TOR)

Residue annotation

ATP binding site c...

2,047I

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,049S

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,050K

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,051Q

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,053P

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,069L

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,071K

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,074E

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,109Y

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,121I

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,122G

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,123W

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,124V

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,129T

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,229N

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,231M

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,242I

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)

2,243D

ATP binding site
2,047I, 2,049S, 2,050K, 2,051Q, 2,053P, 2,069L, 2,071K, 2,074E, 2,109Y, 2,121I, 2,122G, 2,123W, 2,124V, 2,129T, 2,229N, 2,231M, 2,242I, 2,243D
CDD
cd05169 (PIKKc_TOR)
mLST8 interface cd...

2,158A

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,159S

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,160D

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,163K

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,164L

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,165M

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,166L

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,168H

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,170V

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,171E

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)

2,174E

mLST8 interface
2,158A, 2,159S, 2,160D, 2,163K, 2,164L, 2,165M, 2,166L, 2,168H, 2,170V, 2,171E, 2,174E
CDD
cd05169 (PIKKc_TOR)
catalytic loop cd0...

2,221G

catalytic loop
2,221G, 2,222L, 2,223G, 2,224D, 2,225R, 2,226H, 2,227P, 2,228S, 2,229N
CDD
cd05169 (PIKKc_TOR)

2,222L

catalytic loop
2,221G, 2,222L, 2,223G, 2,224D, 2,225R, 2,226H, 2,227P, 2,228S, 2,229N
CDD
cd05169 (PIKKc_TOR)

2,223G

catalytic loop
2,221G, 2,222L, 2,223G, 2,224D, 2,225R, 2,226H, 2,227P, 2,228S, 2,229N
CDD
cd05169 (PIKKc_TOR)

2,224D

catalytic loop
2,221G, 2,222L, 2,223G, 2,224D, 2,225R, 2,226H, 2,227P, 2,228S, 2,229N
CDD
cd05169 (PIKKc_TOR)

2,225R

catalytic loop
2,221G, 2,222L, 2,223G, 2,224D, 2,225R, 2,226H, 2,227P, 2,228S, 2,229N
CDD
cd05169 (PIKKc_TOR)

2,226H

catalytic loop
2,221G, 2,222L, 2,223G, 2,224D, 2,225R, 2,226H, 2,227P, 2,228S, 2,229N
CDD
cd05169 (PIKKc_TOR)

2,227P

catalytic loop
2,221G, 2,222L, 2,223G, 2,224D, 2,225R, 2,226H, 2,227P, 2,228S, 2,229N
CDD
cd05169 (PIKKc_TOR)

2,228S

catalytic loop
2,221G, 2,222L, 2,223G, 2,224D, 2,225R, 2,226H, 2,227P, 2,228S, 2,229N
CDD
cd05169 (PIKKc_TOR)

2,229N

catalytic loop
2,221G, 2,222L, 2,223G, 2,224D, 2,225R, 2,226H, 2,227P, 2,228S, 2,229N
CDD
cd05169 (PIKKc_TOR)
activation loop (A...

2,243D

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,244F

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,245G

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,246D

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,247C

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,248F

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,249E

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,250V

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,251T

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,252Q

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,253T

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,254R

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,255E

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,256K

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,257F

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,258P

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,259E

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,260K

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,261I

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,262P

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,263F

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,264R

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,265L

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

2,266T

activation loop (A-loop)
2,243D, 2,244F, 2,245G, 2,246D, 2,247C, 2,248F, 2,249E, 2,250V, 2,251T, 2,252Q, 2,253T, 2,254R, 2,255E, 2,256K, 2,257F, 2,258P, 2,259E, 2,260K, 2,261I, 2,262P, 2,263F, 2,264R, 2,265L, 2,266T
CDD
cd05169 (PIKKc_TOR)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005488 binding
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0044877 macromolecular complex binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

KWMTBOMO01437

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component