KWMTBOMO01375

Protein

Length

360 amino acids

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
61 - 311
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 360

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PF00106 (adh_short)
  
  69 - 263
  
  Pfam
  PF00106 (adh_short)
2. PR00080 (SDRFAMILY)
  
  216 - 235
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  196 - 204
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  143 - 154
  
  PRINTS
  PR00080 (SDRFAMILY)
3. PR00081 (GDHRDH)
  
  216 - 235
  
  PRINTS
  PR00081 (GDHRDH)
  
  240 - 257
  
  PRINTS
  PR00081 (GDHRDH)
  
  190 - 206
  
  PRINTS
  PR00081 (GDHRDH)
  
  143 - 154
  
  PRINTS
  PR00081 (GDHRDH)
  
  69 - 86
  
  PRINTS
  PR00081 (GDHRDH)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  63 - 311
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  61 - 277
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

no IPR

Unintegrated signatures

cd05339 (17beta-HSD...)

82 - 309

CDD
cd05339 (17beta-HSDXI-like_SDR_c)
mobidb-lite (disord...)

333 - 360

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative NAD(P) bi...

98D

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

99I

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

100N

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

123V

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

124D

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

125L

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

151N

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

152A

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

153G

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

174V

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

201I

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

202A

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

203S

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

216Y

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

220K

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

249P

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

250Y

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

251F

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

252I

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

255T

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

256G

putative NAD(P) binding site
98D, 99I, 100N, 123V, 124D, 125L, 151N, 152A, 153G, 174V, 201I, 202A, 203S, 216Y, 220K, 249P, 250Y, 251F, 252I, 255T, 256G
CDD
cd05339 (17beta-HSDXI-like_SDR_c)
homodimer interfac...

128R

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

132Y

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

164P

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

165D

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

168I

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

169Q

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

172F

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

176I

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

177L

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

180F

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

181W

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

184K

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

213L

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

214V

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

215D

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

217C

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

218S

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

221A

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

222A

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

225G

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

226F

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

228E

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

229A

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

230L

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

232V

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

233E

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

256G

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

257M

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

258F

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

297V

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

298L

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

301F

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

305V

homodimer interface
128R, 132Y, 164P, 165D, 168I, 169Q, 172F, 176I, 177L, 180F, 181W, 184K, 213L, 214V, 215D, 217C, 218S, 221A, 222A, 225G, 226F, 228E, 229A, 230L, 232V, 233E, 256G, 257M, 258F, 297V, 298L, 301F, 305V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)
active site cd05339

175N

active site
175N, 203S, 216Y, 220K
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

203S

active site
175N, 203S, 216Y, 220K
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

216Y

active site
175N, 203S, 216Y, 220K
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

220K

active site
175N, 203S, 216Y, 220K
CDD
cd05339 (17beta-HSDXI-like_SDR_c)
substrate binding ...

184K

substrate binding site
184K, 187L, 230L, 233E, 239V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

187L

substrate binding site
184K, 187L, 230L, 233E, 239V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

230L

substrate binding site
184K, 187L, 230L, 233E, 239V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

233E

substrate binding site
184K, 187L, 230L, 233E, 239V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

239V

substrate binding site
184K, 187L, 230L, 233E, 239V
CDD
cd05339 (17beta-HSDXI-like_SDR_c)

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO01375

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component