KWMTBOMO00913

Protein

Length

444 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
3 - 144
MAD homology 1, Dwarfin-type (IPR003619)
MAD homology, MH1 (IPR013019)
206 - 444
SMAD/FHA domain (IPR008984)
SMAD domain-like (IPR017855)
SMAD domain, Dwarfin-type (IPR001132)

1 50 100 150 200 250 300 350 400 444

Detailed signature matches

IPR003619

MAD homology 1, Dwarfin-type
1. PF03165 (MH1)
  
  31 - 131
  
  Pfam
  PF03165 (MH1)
2. SM00523 (dwAneu5)
  
  25 - 135
  
  SMART
  SM00523 (dwAneu5)
IPR013019

MAD homology, MH1
1. SSF56366 (SMAD MH1 ...)
  
  8 - 131
  
  SUPERFAMILY
  SSF56366 (SMAD MH1 domain)
2. PS51075 (MH1)
  
  7 - 137
  
  PROSITE profiles
  PS51075 (MH1)
3. G3DSA:3.90.52...
  
  3 - 144
  
  GENE3D
  G3DSA:3.90.520.10 (G3DSA:3.90.520.10)
IPR008984

SMAD/FHA domain
1. SSF49879 (SMAD/FHA ...)
  
  206 - 435
  
  SUPERFAMILY
  SSF49879 (SMAD/FHA domain)
IPR017855

SMAD domain-like
1. G3DSA:2.60.20...
  
  245 - 444
  
  GENE3D
  G3DSA:2.60.200.10 (G3DSA:2.60.200.10)
IPR001132

SMAD domain, Dwarfin-type
1. PS51076 (MH2)
  
  251 - 444
  
  PROSITE profiles
  PS51076 (MH2)
2. SM00524 (dwBultra2)
  
  249 - 420
  
  SMART
  SM00524 (dwBultra2)
3. PF03166 (MH2)
  
  250 - 420
  
  Pfam
  PF03166 (MH2)

no IPR

Unintegrated signatures

cd10985 (MH2_SMAD_2_3)

243 - 433

CDD
cd10985 (MH2_SMAD_2_3)

Residue annotation

trimer interface c...

260N

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

265E

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

266T

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

268H

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

279F

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

280T

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

281D

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

282P

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

283S

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

287R

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

291G

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

294S

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

296V

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

297N

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

303E

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

304Q

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

306R

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

307R

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

308H

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

311K

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

380E

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

383F

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

386T

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

390T

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

392R

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

396V

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

397K

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

398G

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

403Y

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

405R

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

409T

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

414W

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

416E

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

418H

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

420N

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

423L

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

424Q

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

426L

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

427D

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

430L

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

431T

trimer interface
260N, 265E, 266T, 268H, 279F, 280T, 281D, 282P, 283S, 287R, 291G, 294S, 296V, 297N, 303E, 304Q, 306R, 307R, 308H, 311K, 380E, 383F, 386T, 390T, 392R, 396V, 397K, 398G, 403Y, 405R, 409T, 414W, 416E, 418H, 420N, 423L, 424Q, 426L, 427D, 430L, 431T
CDD
cd10985 (MH2_SMAD_2_3)

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0007179 transforming growth factor beta receptor signaling pathway

Molecular Function

GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding

Cellular Component

GO:0005622 intracellular
GO:0005667 transcription factor complex

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Entry type

Status

Per-residue features