KWMTBOMO00819

Protein

Length

2,865 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
212 - 269
Zinc finger, CCHC-type (IPR001878)
604 - 783
Reverse transcriptase domain (IPR000477)
1,145 - 1,319
Ribonuclease H-like domain (IPR012337)
Integrase, catalytic core (IPR001584)
1,618 - 1,675
Zinc finger, CCHC-type (IPR001878)
2,010 - 2,189
Reverse transcriptase domain (IPR000477)
2,551 - 2,725
Ribonuclease H-like domain (IPR012337)
Integrase, catalytic core (IPR001584)

1 500 1000 1500 2000 2500 2865

Detailed signature matches

IPR001878

Zinc finger, CCHC-type
1. G3DSA:4.10.60.10
  
  212 - 268
  
  GENE3D
  G3DSA:4.10.60.10 (G3DSA:4.10.60.10)
  
  1,618 - 1,674
  
  GENE3D
  G3DSA:4.10.60.10 (G3DSA:4.10.60.10)
2. SM00343 (c2hcfinal6)
  
  1,659 - 1,675
  
  SMART
  SM00343 (c2hcfinal6)
  
  1,623 - 1,639
  
  SMART
  SM00343 (c2hcfinal6)
  
  217 - 233
  
  SMART
  SM00343 (c2hcfinal6)
  
  253 - 269
  
  SMART
  SM00343 (c2hcfinal6)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  2,029 - 2,189
  
  Pfam
  PF00078 (RVT_1)
  
  623 - 783
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  2,010 - 2,189
  
  PROSITE profiles
  PS50878 (RT_POL)
  
  604 - 783
  
  PROSITE profiles
  PS50878 (RT_POL)
IPR012337

Ribonuclease H-like domain
1. G3DSA:3.30.42...
  
  2,560 - 2,717
  
  GENE3D
  G3DSA:3.30.420.10 (G3DSA:3.30.420.10)
  
  1,154 - 1,311
  
  GENE3D
  G3DSA:3.30.420.10 (G3DSA:3.30.420.10)
2. SSF53098 (Ribonucle...)
  
  1,151 - 1,301
  
  SUPERFAMILY
  SSF53098 (Ribonuclease H-like)
  
  2,557 - 2,707
  
  SUPERFAMILY
  SSF53098 (Ribonuclease H-like)
IPR001584

Integrase, catalytic core
1. PS50994 (INTEGRASE)
  
  1,145 - 1,319
  
  PROSITE profiles
  PS50994 (INTEGRASE)
  
  2,551 - 2,725
  
  PROSITE profiles
  PS50994 (INTEGRASE)
2. PF00665 (rve)
  
  1,152 - 1,264
  
  Pfam
  PF00665 (rve)
  
  2,558 - 2,670
  
  Pfam
  PF00665 (rve)

no IPR

Unintegrated signatures

Coil

2,741 - 2,765

COILS
Coil (Coil)

1,335 - 1,359

COILS
Coil (Coil)
G3DSA:3.10.10.10

1,985 - 2,123

GENE3D
G3DSA:3.10.10.10 (G3DSA:3.10.10.10)

579 - 717

GENE3D
G3DSA:3.10.10.10 (G3DSA:3.10.10.10)
SSF56672 (DNA/RNA p...)

551 - 980

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)

1,957 - 2,386

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd01647 (RT_LTR)

2,013 - 2,189

CDD
cd01647 (RT_LTR)

607 - 783

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

2,283 - 2,402

CDD
cd09274 (RNase_HI_RT_Ty3)

877 - 996

CDD
cd09274 (RNase_HI_RT_Ty3)

Residue annotation

putative NTP bindi...

670D

putative NTP binding site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 734D
CDD
cd01647 (RT_LTR)

671L

putative NTP binding site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 734D
CDD
cd01647 (RT_LTR)

672Q

putative NTP binding site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 734D
CDD
cd01647 (RT_LTR)

673S

putative NTP binding site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 734D
CDD
cd01647 (RT_LTR)

674G

putative NTP binding site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 734D
CDD
cd01647 (RT_LTR)

675Y

putative NTP binding site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 734D
CDD
cd01647 (RT_LTR)

704F

putative NTP binding site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 734D
CDD
cd01647 (RT_LTR)

734D

putative NTP binding site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 734D
CDD
cd01647 (RT_LTR)
putative active si...

670D

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

671L

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

672Q

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

673S

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

674G

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

675Y

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

704F

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

705G

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

732Y

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

734D

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

735E

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

779L

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)

780G

putative active site
670D, 671L, 672Q, 673S, 674G, 675Y, 704F, 705G, 732Y, 734D, 735E, 779L, 780G
CDD
cd01647 (RT_LTR)
putative nucleic a...

705G

putative nucleic acid binding site
705G
CDD
cd01647 (RT_LTR)
active site cd09274

881D

active site
881D, 922E, 947D, 990D
CDD
cd09274 (RNase_HI_RT_Ty3)

922E

active site
881D, 922E, 947D, 990D
CDD
cd09274 (RNase_HI_RT_Ty3)

947D

active site
881D, 922E, 947D, 990D
CDD
cd09274 (RNase_HI_RT_Ty3)

990D

active site
881D, 922E, 947D, 990D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

881D

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

882A

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

883S

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

884Q

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

917T

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

918V

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

919T

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

922E

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

947D

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

980Y

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)

994R

RNA/DNA hybrid binding site
881D, 882A, 883S, 884Q, 917T, 918V, 919T, 922E, 947D, 980Y, 994R
CDD
cd09274 (RNase_HI_RT_Ty3)
putative NTP bindi...

2,076D

putative NTP binding site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,140D
CDD
cd01647 (RT_LTR)

2,077L

putative NTP binding site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,140D
CDD
cd01647 (RT_LTR)

2,078Q

putative NTP binding site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,140D
CDD
cd01647 (RT_LTR)

2,079S

putative NTP binding site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,140D
CDD
cd01647 (RT_LTR)

2,080G

putative NTP binding site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,140D
CDD
cd01647 (RT_LTR)

2,081Y

putative NTP binding site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,140D
CDD
cd01647 (RT_LTR)

2,110F

putative NTP binding site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,140D
CDD
cd01647 (RT_LTR)

2,140D

putative NTP binding site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,140D
CDD
cd01647 (RT_LTR)
putative active si...

2,076D

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,077L

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,078Q

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,079S

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,080G

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,081Y

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,110F

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,111G

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,138Y

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,140D

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,141E

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,185L

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)

2,186G

putative active site
2,076D, 2,077L, 2,078Q, 2,079S, 2,080G, 2,081Y, 2,110F, 2,111G, 2,138Y, 2,140D, 2,141E, 2,185L, 2,186G
CDD
cd01647 (RT_LTR)
putative nucleic a...

2,111G

putative nucleic acid binding site
2,111G
CDD
cd01647 (RT_LTR)
active site cd09274

2,287D

active site
2,287D, 2,328E, 2,353D, 2,396D
CDD
cd09274 (RNase_HI_RT_Ty3)

2,328E

active site
2,287D, 2,328E, 2,353D, 2,396D
CDD
cd09274 (RNase_HI_RT_Ty3)

2,353D

active site
2,287D, 2,328E, 2,353D, 2,396D
CDD
cd09274 (RNase_HI_RT_Ty3)

2,396D

active site
2,287D, 2,328E, 2,353D, 2,396D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

2,287D

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,288A

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,289S

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,290Q

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,323T

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,324V

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,325T

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,328E

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,353D

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,386Y

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

2,400R

RNA/DNA hybrid binding site
2,287D, 2,288A, 2,289S, 2,290Q, 2,323T, 2,324V, 2,325T, 2,328E, 2,353D, 2,386Y, 2,400R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

GO:0015074 DNA integration

Molecular Function

GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO00819

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component