KWMTBOMO00710

Protein

Length

839 amino acids

Protein family membership

Hydroxymethylglutaryl-CoA reductase, class I/II (IPR002202)
- Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type (IPR004554)

Domains and repeats

Domain
62 - 218
Sterol-sensing domain (IPR000731)
398 - 531
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain (IPR009029)
648 - 806
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain (IPR009029)
Domain
403 - 483
Hydroxymethylglutaryl-CoA reductase, N-terminal (IPR023282)
534 - 650
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain (IPR009023)
Domain
485 - 530
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain (IPR023074)
650 - 819
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain (IPR023074)

1 100 200 300 400 500 600 700 839

Detailed signature matches

IPR002202

Hydroxymethylglutaryl-CoA reductase, class I/II
1. PR00071 (HMGCOARDTASE)
  
  591 - 609
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  682 - 708
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  501 - 521
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  631 - 656
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  474 - 495
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  737 - 758
  
  PRINTS
  PR00071 (HMGCOARDTASE)
2. PS50065 (HMG_COA_RE...)
  
  412 - 817
  
  PROSITE profiles
  PS50065 (HMG_COA_REDUCTASE_4)
3. PF00368 (HMG-CoA_red)
  
  441 - 817
  
  Pfam
  PF00368 (HMG-CoA_red)
IPR004554

Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
1. TIGR00533
  
  411 - 817
  
  TIGRFAMs
  TIGR00533 (TIGR00533)
2. cd00643 (HMG-CoA_re...)
  
  413 - 817
  
  CDD
  cd00643 (HMG-CoA_reductase_classI)
IPR000731

Sterol-sensing domain
1. PS50156 (SSD)
  
  62 - 217
  
  PROSITE profiles
  PS50156 (SSD)
2. PF12349 (Sterol-sen...)
  
  87 - 218
  
  Pfam
  PF12349 (Sterol-sensing)
IPR009029

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
1. SSF56542 (Substrate...)
  
  648 - 806
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
  
  398 - 531
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
IPR023282

Hydroxymethylglutaryl-CoA reductase, N-terminal
1. G3DSA:1.10.32...
  
  403 - 483
  
  GENE3D
  G3DSA:1.10.3270.10 (G3DSA:1.10.3270.10)
IPR023074

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
1. G3DSA:3.90.77...
  
  650 - 819
  
  GENE3D
  G3DSA:3.90.770.10 (G3DSA:3.90.770.10)
  
  485 - 530
  
  GENE3D
  G3DSA:3.90.770.10 (G3DSA:3.90.770.10)
IPR009023

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
1. SSF55035 (NAD-bindi...)
  
  534 - 650
  
  SUPERFAMILY
  SSF55035 (NAD-binding domain of HMG-CoA reductase)
2. G3DSA:3.30.70...
  
  534 - 649
  
  GENE3D
  G3DSA:3.30.70.420 (G3DSA:3.30.70.420)
IPR023076

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
1. PS00066 (HMG_COA_RE...)
  
  593 - 607
  
  PROSITE patterns
  PS00066 (HMG_COA_REDUCTASE_1)
2. PS01192 (HMG_COA_RE...)
  
  802 - 815
  
  PROSITE patterns
  PS01192 (HMG_COA_REDUCTASE_3)
3. PS00318 (HMG_COA_RE...)
  
  749 - 756
  
  PROSITE patterns
  PS00318 (HMG_COA_REDUCTASE_2)

no IPR

Unintegrated signatures

G3DSA:1.20.16...

143 - 227

GENE3D
G3DSA:1.20.1640.10 (G3DSA:1.20.1640.10)
PS51257 (PROKAR_LIP...)

1 - 28

PROSITE profiles
PS51257 (PROKAR_LIPOPROTEIN)

Residue annotation

tetramerization in...

456A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

457I

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

459Q

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

460L

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

465Y

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

470V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

473A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

474C

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

475C

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

476E

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

477N

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

478V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

479I

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

480G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

481Y

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

482I

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

483G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

484V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

485P

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

486V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

487G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

488Y

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

500M

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

505T

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

506T

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

507E

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

508G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

509A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

510L

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

511V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

512A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

527T

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

529V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

531E

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

542K

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

550H

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

582H

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

585V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

587G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

588A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

589T

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

591Y

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

628I

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

630L

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

631S

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

632G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

633N

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

634Y

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

636S

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

638K

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

639K

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

640A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

641A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

642A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

643I

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

645W

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

646I

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

647K

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

654V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

656E

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

658V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

677R

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

678C

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

680K

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

681I

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

682K

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

683N

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

684L

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

685S

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

686G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

687S

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

688A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

689L

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

695G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

696N

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

697N

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

698A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

701A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

702N

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

705T

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

709I

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

710A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

714D

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

715P

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

716A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

718N

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

719V

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

727N

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

729E

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

739Y

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

741T

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

743T

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

755G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

760G

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

761Q

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

763A

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

764C

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

766E

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

767I

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

803L

tetramerization interface
456A, 457I, 459Q, 460L, 465Y, 470V, 473A, 474C, 475C, 476E, 477N, 478V, 479I, 480G, 481Y, 482I, 483G, 484V, 485P, 486V, 487G, 488Y, 500M, 505T, 506T, 507E, 508G, 509A, 510L, 511V, 512A, 527T, 529V, 531E, 542K, 550H, 582H, 585V, 587G, 588A, 589T, 591Y, 628I, 630L, 631S, 632G, 633N, 634Y, 636S, 638K, 639K, 640A, 641A, 642A, 643I, 645W, 646I, 647K, 654V, 656E, 658V, 677R, 678C, 680K, 681I, 682K, 683N, 684L, 685S, 686G, 687S, 688A, 689L, 695G, 696N, 697N, 698A, 701A, 702N, 705T, 709I, 710A, 714D, 715P, 716A, 718N, 719V, 727N, 729E, 739Y, 741T, 743T, 755G, 760G, 761Q, 763A, 764C, 766E, 767I, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)
inhibitor binding ...

507E

inhibitor binding sites
507E, 510L, 513S, 682K, 698A, 699H, 702N, 799L, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

510L

inhibitor binding sites
507E, 510L, 513S, 682K, 698A, 699H, 702N, 799L, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

513S

inhibitor binding sites
507E, 510L, 513S, 682K, 698A, 699H, 702N, 799L, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

682K

inhibitor binding sites
507E, 510L, 513S, 682K, 698A, 699H, 702N, 799L, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

698A

inhibitor binding sites
507E, 510L, 513S, 682K, 698A, 699H, 702N, 799L, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

699H

inhibitor binding sites
507E, 510L, 513S, 682K, 698A, 699H, 702N, 799L, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

702N

inhibitor binding sites
507E, 510L, 513S, 682K, 698A, 699H, 702N, 799L, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

799L

inhibitor binding sites
507E, 510L, 513S, 682K, 698A, 699H, 702N, 799L, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)

803L

inhibitor binding sites
507E, 510L, 513S, 682K, 698A, 699H, 702N, 799L, 803L
CDD
cd00643 (HMG-CoA_reductase_classI)
catalytic residues...

507E

catalytic residues
507E, 638K, 714D, 812H
CDD
cd00643 (HMG-CoA_reductase_classI)

638K

catalytic residues
507E, 638K, 714D, 812H
CDD
cd00643 (HMG-CoA_reductase_classI)

714D

catalytic residues
507E, 638K, 714D, 812H
CDD
cd00643 (HMG-CoA_reductase_classI)

812H

catalytic residues
507E, 638K, 714D, 812H
CDD
cd00643 (HMG-CoA_reductase_classI)
substrate binding ...

507E

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

509A

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

510L

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

512A

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

513S

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

515N

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

516R

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

519K

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

669K

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

699H

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

702N

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

798S

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

799L

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

802A

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

808L

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

811S

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

812H

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)

815H

substrate binding pocket
507E, 509A, 510L, 512A, 513S, 515N, 516R, 519K, 669K, 699H, 702N, 798S, 799L, 802A, 808L, 811S, 812H, 815H
CDD
cd00643 (HMG-CoA_reductase_classI)
NADP(H) binding si...

537R

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

573S

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

574R

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

575F

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

598T

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

599G

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

600D

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

601A

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

602M

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

603G

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

604M

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

605N

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

606M

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

608S

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

637D

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

638K

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

714D

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

752V

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

753G

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

754G

NADP(H) binding site
537R, 573S, 574R, 575F, 598T, 599G, 600D, 601A, 602M, 603G, 604M, 605N, 606M, 608S, 637D, 638K, 714D, 752V, 753G, 754G
CDD
cd00643 (HMG-CoA_reductase_classI)

GO term prediction

Biological Process

GO:0008299 isoprenoid biosynthetic process
GO:0015936 coenzyme A metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0050662 coenzyme binding

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features