KWMTBOMO00497

Protein

Length

327 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
7 - 109
NAD(P)-binding domain (IPR016040)
105 - 288
NAD(P)-binding domain (IPR016040)
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)
Domain
8 - 313
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)

1 50 100 150 200 250 300 327

Detailed signature matches

IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  105 - 287
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  110 - 288
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
  
  7 - 109
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  8 - 313
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  111 - 287
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR029752

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
1. PS00065 (D_2_HYDROX...)
  
  147 - 174
  
  PROSITE patterns
  PS00065 (D_2_HYDROXYACID_DH_1)

no IPR

Unintegrated signatures

SSF52283 (Formate/g...)

7 - 126

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
cd12173 (PGDH_4)

8 - 310

CDD
cd12173 (PGDH_4)

Residue annotation

ligand binding sit...

53R

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)

54S

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)

74R

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)

76G

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)

77A

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)

101N

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)

235R

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)

285H

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)

288A

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)

294Q

ligand binding site
53R, 54S, 74R, 76G, 77A, 101N, 235R, 285H, 288A, 294Q
CDD
cd12173 (PGDH_4)
NAD binding site c...

77A

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

101N

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

105A

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

151G

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

153G

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

154R

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

155V

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

173F

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

174D

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

175P

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

176F

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

205H

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

206T

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

207P

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

212T

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

233V

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

234G

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

235R

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

259D

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

260V

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

285H

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

287G

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)

288A

NAD binding site
77A, 101N, 105A, 151G, 153G, 154R, 155V, 173F, 174D, 175P, 176F, 205H, 206T, 207P, 212T, 233V, 234G, 235R, 259D, 260V, 285H, 287G, 288A
CDD
cd12173 (PGDH_4)
dimerization inter...

103L

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

104S

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

107E

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

108L

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

110C

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

111T

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

114L

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

115V

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

118R

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

120V

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

121V

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

123A

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

124S

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

127L

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

128K

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

130G

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

131R

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

132W

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

134R

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

137Y

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

138T

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

139G

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

140S

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

141E

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

142L

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

143A

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

145K

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

162R

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

165A

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

166F

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

261F

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

264E

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

265P

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

266P

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

272L

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

275I

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

276Q

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

277Q

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

278P

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

280V

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

281I

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

282A

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

283T

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

284P

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

285H

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

286L

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

287G

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

289S

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

290T

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

291K

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

292E

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)

296R

dimerization interface
103L, 104S, 107E, 108L, 110C, 111T, 114L, 115V, 118R, 120V, 121V, 123A, 124S, 127L, 128K, 130G, 131R, 132W, 134R, 137Y, 138T, 139G, 140S, 141E, 142L, 143A, 145K, 162R, 165A, 166F, 261F, 264E, 265P, 266P, 272L, 275I, 276Q, 277Q, 278P, 280V, 281I, 282A, 283T, 284P, 285H, 286L, 287G, 289S, 290T, 291K, 292E, 296R
CDD
cd12173 (PGDH_4)
catalytic site cd1...

235R

catalytic site
235R, 264E, 285H
CDD
cd12173 (PGDH_4)

264E

catalytic site
235R, 264E, 285H
CDD
cd12173 (PGDH_4)

285H

catalytic site
235R, 264E, 285H
CDD
cd12173 (PGDH_4)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component