KWMTBOMO00493

Protein

Length

610 amino acids

Protein family membership

Enolase (IPR000941)

Domains and repeats

Domain
78 - 145
Myc-type, basic helix-loop-helix (bHLH) domain (IPR011598)
180 - 315
Enolase N-terminal domain-like (IPR029017)
Enolase, N-terminal (IPR020811)
Domain
305 - 609
Enolase C-terminal domain-like (IPR029065)
Enolase, C-terminal TIM barrel domain (IPR020810)

1 100 200 300 400 500 610

Detailed signature matches

IPR000941

Enolase
1. MF_00318 (Enolase)
  
  178 - 595
  
  HAMAP
  MF_00318 (Enolase)
2. cd03313 (enolase)
  
  185 - 594
  
  CDD
  cd03313 (enolase)
3. PR00148 (ENOLASE)
  
  284 - 300
  
  PRINTS
  PR00148 (ENOLASE)
  
  495 - 506
  
  PRINTS
  PR00148 (ENOLASE)
  
  341 - 354
  
  PRINTS
  PR00148 (ENOLASE)
  
  547 - 564
  
  PRINTS
  PR00148 (ENOLASE)
  
  518 - 532
  
  PRINTS
  PR00148 (ENOLASE)
  
  212 - 226
  
  PRINTS
  PR00148 (ENOLASE)
IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain
1. G3DSA:4.10.28...
  
  78 - 140
  
  GENE3D
  G3DSA:4.10.280.10 (G3DSA:4.10.280.10)
2. SM00353 (finulus)
  
  89 - 141
  
  SMART
  SM00353 (finulus)
3. PF00010 (HLH)
  
  84 - 135
  
  Pfam
  PF00010 (HLH)
4. PS50888 (BHLH)
  
  83 - 135
  
  PROSITE profiles
  PS50888 (BHLH)
5. SSF47459 (HLH, heli...)
  
  83 - 145
  
  SUPERFAMILY
  SSF47459 (HLH, helix-loop-helix DNA-binding domain)
IPR029017

Enolase N-terminal domain-like
1. G3DSA:3.30.39...
  
  180 - 303
  
  GENE3D
  G3DSA:3.30.390.10 (G3DSA:3.30.390.10)
2. SSF54826 (Enolase N...)
  
  180 - 315
  
  SUPERFAMILY
  SSF54826 (Enolase N-terminal domain-like)
IPR020811

Enolase, N-terminal
1. SM01193 (Enolase_N_3)
  
  180 - 311
  
  SMART
  SM01193 (Enolase_N_3)
2. PF03952 (Enolase_N)
  
  181 - 311
  
  Pfam
  PF03952 (Enolase_N)
IPR029065

Enolase C-terminal domain-like
1. SSF51604 (Enolase C...)
  
  320 - 606
  
  SUPERFAMILY
  SSF51604 (Enolase C-terminal domain-like)
2. G3DSA:3.20.20...
  
  305 - 607
  
  GENE3D
  G3DSA:3.20.20.120 (G3DSA:3.20.20.120)
IPR020810

Enolase, C-terminal TIM barrel domain
1. SM01192 (Enolase_C_3)
  
  319 - 609
  
  SMART
  SM01192 (Enolase_C_3)
2. PF00113 (Enolase_C)
  
  320 - 607
  
  Pfam
  PF00113 (Enolase_C)

no IPR

Unintegrated signatures

cd00083 (HLH)

87 - 140

CDD
cd00083 (HLH)
mobidb-lite (disord...)

49 - 91

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

DNA binding region...

91R

DNA binding region
91R, 92E, 93R, 95R, 118R, 121K
CDD
cd00083 (HLH)

92E

DNA binding region
91R, 92E, 93R, 95R, 118R, 121K
CDD
cd00083 (HLH)

93R

DNA binding region
91R, 92E, 93R, 95R, 118R, 121K
CDD
cd00083 (HLH)

95R

DNA binding region
91R, 92E, 93R, 95R, 118R, 121K
CDD
cd00083 (HLH)

118R

DNA binding region
91R, 92E, 93R, 95R, 118R, 121K
CDD
cd00083 (HLH)

121K

DNA binding region
91R, 92E, 93R, 95R, 118R, 121K
CDD
cd00083 (HLH)
E-box/N-box specif...

92E

E-box/N-box specificity site
92E
CDD
cd00083 (HLH)
dimerization inter...

98S

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

99I

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

102A

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

103F

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

105G

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

106L

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

122V

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

125L

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

129I

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

131Y

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

132I

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

136G

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

138L

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)

139V

dimerization interface
98S, 99I, 102A, 103F, 105G, 106L, 122V, 125L, 129I, 131Y, 132I, 136G, 138L, 139V
CDD
cd00083 (HLH)
dimer interface cd...

186R

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

187Q

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

188I

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

189F

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

190D

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

191S

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

192T

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

193G

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

194V

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

198E

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

209R

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

336S

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

337S

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

338N

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

359M

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

360R

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

363S

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

364E

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

367R

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

368Y

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

383Y

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

384V

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

391S

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

393P

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

553D

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

554T

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

555E

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

578R

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

579S

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

580E

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

582V

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

583G

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

586N

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

589I

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

590R

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)

593E

dimer interface
186R, 187Q, 188I, 189F, 190D, 191S, 192T, 193G, 194V, 198E, 209R, 336S, 337S, 338N, 359M, 360R, 363S, 364E, 367R, 368Y, 383Y, 384V, 391S, 393P, 553D, 554T, 555E, 578R, 579S, 580E, 582V, 583G, 586N, 589I, 590R, 593E
CDD
cd03313 (enolase)
metal binding site...

217S

metal binding site
217S, 422N, 471E, 496N
CDD
cd03313 (enolase)

422N

metal binding site
217S, 422N, 471E, 496N
CDD
cd03313 (enolase)

471E

metal binding site
217S, 422N, 471E, 496N
CDD
cd03313 (enolase)

496N

metal binding site
217S, 422N, 471E, 496N
CDD
cd03313 (enolase)
substrate binding ...

335L

substrate binding pocket
335L, 387S, 521R, 549D, 550R, 551W, 572K
CDD
cd03313 (enolase)

387S

substrate binding pocket
335L, 387S, 521R, 549D, 550R, 551W, 572K
CDD
cd03313 (enolase)

521R

substrate binding pocket
335L, 387S, 521R, 549D, 550R, 551W, 572K
CDD
cd03313 (enolase)

549D

substrate binding pocket
335L, 387S, 521R, 549D, 550R, 551W, 572K
CDD
cd03313 (enolase)

550R

substrate binding pocket
335L, 387S, 521R, 549D, 550R, 551W, 572K
CDD
cd03313 (enolase)

551W

substrate binding pocket
335L, 387S, 521R, 549D, 550R, 551W, 572K
CDD
cd03313 (enolase)

572K

substrate binding pocket
335L, 387S, 521R, 549D, 550R, 551W, 572K
CDD
cd03313 (enolase)

GO term prediction

Biological Process

GO:0006096 glycolytic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0046983 protein dimerization activity

Cellular Component

GO:0000015 phosphopyruvate hydratase complex

Filter view on

Entry type

Status

Per-residue features