KWMTBOMO00487

Protein

Length

223 amino acids

Protein family membership

Peroxiredoxin, AhpC-type (IPR024706)

Domains and repeats

Domain
1 - 217
Thioredoxin-like fold (IPR012336)
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant (IPR000866)
Thioredoxin domain (IPR013766)
Domain
163 - 202
Peroxiredoxin, C-terminal (IPR019479)

1 50 100 150 223

Detailed signature matches

IPR024706

Peroxiredoxin, AhpC-type
1. PIRSF000239 (AHPC)
  
  1 - 219
  
  PIRSF
  PIRSF000239 (AHPC)
IPR012336

Thioredoxin-like fold
1. SSF52833 (Thioredox...)
  
  1 - 217
  
  SUPERFAMILY
  SSF52833 (Thioredoxin-like)
2. G3DSA:3.40.30.10
  
  3 - 162
  
  GENE3D
  G3DSA:3.40.30.10 (G3DSA:3.40.30.10)
IPR013766

Thioredoxin domain
1. PS51352 (THIOREDOXIN_2)
  
  2 - 166
  
  PROSITE profiles
  PS51352 (THIOREDOXIN_2)
IPR000866

Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
1. PF00578 (AhpC-TSA)
  
  5 - 141
  
  Pfam
  PF00578 (AhpC-TSA)
IPR019479

Peroxiredoxin, C-terminal
1. PF10417 (1-cysPrx_C)
  
  163 - 202
  
  Pfam
  PF10417 (1-cysPrx_C)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

163 - 222

GENE3D
G3DSA:3.30.1020.10 (G3DSA:3.30.1020.10)
SFLDS00024 (Peroxir...)

5 - 169

SFLD
SFLDS00024 (Peroxiredoxin)
cd03016 (PRX_1cys)

4 - 218

CDD
cd03016 (PRX_1cys)

Residue annotation

dimer interface cd...

4L

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

42P

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

45T

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

46T

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

47E

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

50R

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

82D

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

85S

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

112G

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

127T

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

141R

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

142L

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

143S

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

145L

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

146Y

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

147P

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

149T

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

150T

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

151G

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

152R

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

153N

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

154F

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

156E

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

159R

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

163S

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

164L

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

173A

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

174T

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

176V

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

177D

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

214Y

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)

217K

dimer interface
4L, 42P, 45T, 46T, 47E, 50R, 82D, 85S, 112G, 127T, 141R, 142L, 143S, 145L, 146Y, 147P, 149T, 150T, 151G, 152R, 153N, 154F, 156E, 159R, 163S, 164L, 173A, 174T, 176V, 177D, 214Y, 217K
CDD
cd03016 (PRX_1cys)
decamer (pentamer ...

16T

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

70C

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

71D

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

72S

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

74S

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

75S

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

77L

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

78E

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

80C

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

81K

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

94P

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

103E

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

104K

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

114I

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

125P

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

126L

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

189T

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)

207P

decamer (pentamer of dimers) interface
16T, 70C, 71D, 72S, 74S, 75S, 77L, 78E, 80C, 81K, 94P, 103E, 104K, 114I, 125P, 126L, 189T, 207P
CDD
cd03016 (PRX_1cys)
SFLDS00024

41T

SFLD_Res01
41T, 44C
SFLD
SFLDS00024 (Peroxiredoxin)

44C

SFLD_Res01
41T, 44C
SFLD
SFLDS00024 (Peroxiredoxin)
catalytic triad cd...

41T

catalytic triad
41T, 44C, 129R
CDD
cd03016 (PRX_1cys)

44C

catalytic triad
41T, 44C, 129R
CDD
cd03016 (PRX_1cys)

129R

catalytic triad
41T, 44C, 129R
CDD
cd03016 (PRX_1cys)

GO term prediction

Biological Process

GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0051920 peroxiredoxin activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features