KWMTBOMO00380

Protein

Length

255 amino acids

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
2 - 252
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 255

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PF00106 (adh_short)
  
  6 - 204
  
  Pfam
  PF00106 (adh_short)
2. PR00080 (SDRFAMILY)
  
  142 - 150
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  162 - 181
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  77 - 88
  
  PRINTS
  PR00080 (SDRFAMILY)
3. PR00081 (GDHRDH)
  
  183 - 200
  
  PRINTS
  PR00081 (GDHRDH)
  
  77 - 88
  
  PRINTS
  PR00081 (GDHRDH)
  
  6 - 23
  
  PRINTS
  PR00081 (GDHRDH)
  
  162 - 181
  
  PRINTS
  PR00081 (GDHRDH)
  
  136 - 152
  
  PRINTS
  PR00081 (GDHRDH)
  
  217 - 237
  
  PRINTS
  PR00081 (GDHRDH)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  2 - 251
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  2 - 252
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
IPR020904

Short-chain dehydrogenase/reductase, conserved site
1. PS00061 (ADH_SHORT)
  
  149 - 177
  
  PROSITE patterns
  PS00061 (ADH_SHORT)

no IPR

Unintegrated signatures

cd05371 (HSD10-like...)

3 - 255

CDD
cd05371 (HSD10-like_SDR_c)

Residue annotation

NAD binding site c...

11G

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

14S

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

15G

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

16L

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

35D

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

36L

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

57V

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

58D

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

59V

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

85C

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

86A

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

87G

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

114V

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

147T

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

148A

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

149S

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

162Y

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

166K

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

192P

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

193G

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

194L

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

195F

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

197T

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

198P

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

199M

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)

200M

NAD binding site
11G, 14S, 15G, 16L, 35D, 36L, 57V, 58D, 59V, 85C, 86A, 87G, 114V, 147T, 148A, 149S, 162Y, 166K, 192P, 193G, 194L, 195F, 197T, 198P, 199M, 200M
CDD
cd05371 (HSD10-like_SDR_c)
homotetramer inter...

93R

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

94V

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

95Y

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

97F

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

102P

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

103F

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

105L

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

108F

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

109Q

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

112I

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

116L

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

117I

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

120F

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

121N

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

124R

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

127V

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

128G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

131G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

138D

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

139G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

140Q

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

152A

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

153F

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

154D

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

155G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

156Q

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

157I

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

158G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

160A

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

163S

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

164A

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

167A

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

168G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

171G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

172M

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

174L

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

175P

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

176L

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

178R

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

179D

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

181A

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

182K

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

183Q

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

184G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

186R

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

195F

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

216P

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

217F

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

218P

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

220R

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

221L

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

222G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

226E

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

229L

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

230L

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

233S

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

235I

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

236Q

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

237N

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

238P

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

239M

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

240L

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

241N

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

242G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

243E

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

244T

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

245I

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

246R

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

247L

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

248D

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

249G

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

250S

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

252R

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

253M

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

254Q

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

255P

homotetramer interface
93R, 94V, 95Y, 97F, 102P, 103F, 105L, 108F, 109Q, 112I, 116L, 117I, 120F, 121N, 124R, 127V, 128G, 131G, 138D, 139G, 140Q, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 174L, 175P, 176L, 178R, 179D, 181A, 182K, 183Q, 184G, 186R, 195F, 216P, 217F, 218P, 220R, 221L, 222G, 226E, 229L, 230L, 233S, 235I, 236Q, 237N, 238P, 239M, 240L, 241N, 242G, 243E, 244T, 245I, 246R, 247L, 248D, 249G, 250S, 252R, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)
homodimer interfac...

93R

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

94V

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

95Y

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

102P

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

103F

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

105L

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

108F

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

112I

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

117I

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

120F

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

121N

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

124R

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

152A

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

153F

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

154D

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

155G

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

156Q

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

157I

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

158G

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

160A

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

163S

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

164A

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

167A

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

168G

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

171G

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

172M

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

175P

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

176L

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

178R

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

179D

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

253M

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

254Q

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)

255P

homodimer interface
93R, 94V, 95Y, 102P, 103F, 105L, 108F, 112I, 117I, 120F, 121N, 124R, 152A, 153F, 154D, 155G, 156Q, 157I, 158G, 160A, 163S, 164A, 167A, 168G, 171G, 172M, 175P, 176L, 178R, 179D, 253M, 254Q, 255P
CDD
cd05371 (HSD10-like_SDR_c)
active site cd05371

115N

active site
115N, 149S, 162Y, 166K
CDD
cd05371 (HSD10-like_SDR_c)

149S

active site
115N, 149S, 162Y, 166K
CDD
cd05371 (HSD10-like_SDR_c)

162Y

active site
115N, 149S, 162Y, 166K
CDD
cd05371 (HSD10-like_SDR_c)

166K

active site
115N, 149S, 162Y, 166K
CDD
cd05371 (HSD10-like_SDR_c)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO00380

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component