KWMTBOMO00007

Protein

Length

1,276 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
156 - 345
Adenylate cyclase, N-terminal (IPR032628)
541 - 629
Adenylate cyclase, conserved domain (IPR009398)
Domain
310 - 531
Nucleotide cyclase (IPR029787)
Adenylyl cyclase class-3/4/guanylyl cyclase (IPR001054)
859 - 1,090
Nucleotide cyclase (IPR029787)
Adenylyl cyclase class-3/4/guanylyl cyclase (IPR001054)

1 200 400 600 800 1000 1276

Detailed signature matches

IPR032628

Adenylate cyclase, N-terminal
1. PF16214 (AC_N)
  
  156 - 345
  
  Pfam
  PF16214 (AC_N)
IPR029787

Nucleotide cyclase
1. SSF55073 (Nucleotid...)
  
  344 - 529
  
  SUPERFAMILY
  SSF55073 (Nucleotide cyclase)
  
  898 - 1,087
  
  SUPERFAMILY
  SSF55073 (Nucleotide cyclase)
IPR001054

Adenylyl cyclase class-3/4/guanylyl cyclase
1. PS50125 (GUANYLATE_...)
  
  904 - 1,043
  
  PROSITE profiles
  PS50125 (GUANYLATE_CYCLASE_2)
  
  356 - 483
  
  PROSITE profiles
  PS50125 (GUANYLATE_CYCLASE_2)
2. SM00044 (cyc_6)
  
  310 - 509
  
  SMART
  SM00044 (cyc_6)
  
  859 - 1,072
  
  SMART
  SM00044 (cyc_6)
3. G3DSA:3.30.70...
  
  893 - 1,090
  
  GENE3D
  G3DSA:3.30.70.1230 (G3DSA:3.30.70.1230)
  
  342 - 531
  
  GENE3D
  G3DSA:3.30.70.1230 (G3DSA:3.30.70.1230)
4. PF00211 (Guanylate_cyc)
  
  896 - 1,089
  
  Pfam
  PF00211 (Guanylate_cyc)
  
  348 - 508
  
  Pfam
  PF00211 (Guanylate_cyc)
IPR009398

Adenylate cyclase, conserved domain
1. PF06327 (DUF1053)
  
  541 - 629
  
  Pfam
  PF06327 (DUF1053)
IPR018297

Adenylyl cyclase class-4/guanylyl cyclase, conserved site
1. PS00452 (GUANYLATE_...)
  
  1,020 - 1,043
  
  PROSITE patterns
  PS00452 (GUANYLATE_CYCLASE_1)

no IPR

Unintegrated signatures

Coil

374 - 394

COILS
Coil (Coil)

850 - 870

COILS
Coil (Coil)
cd07302 (CHD)

903 - 1,087

CDD
cd07302 (CHD)

354 - 509

CDD
cd07302 (CHD)
mobidb-lite (disord...)

1,098 - 1,173

MobiDB Lite
mobidb-lite (disorder_prediction)

560 - 581

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

nucleotidyl bindin...

359F

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

361D

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

362I

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

363C

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

364G

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

365F

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

366T

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

401K

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

403L

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

404G

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

405D

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

408Y

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

470D

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

471V

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

472W

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

476V

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

477T

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

480N

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)

481Y

nucleotidyl binding site
359F, 361D, 362I, 363C, 364G, 365F, 366T, 401K, 403L, 404G, 405D, 408Y, 470D, 471V, 472W, 476V, 477T, 480N, 481Y
CDD
cd07302 (CHD)
metal binding site...

361D

metal binding site
361D, 405D
CDD
cd07302 (CHD)

405D

metal binding site
361D, 405D
CDD
cd07302 (CHD)
dimer interface cd...

366T

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

378V

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

381L

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

382N

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

385F

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

389D

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

401K

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

402L

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

458H

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

461V

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

471V

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

472W

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

473S

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

474N

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)

477T

dimer interface
366T, 378V, 381L, 382N, 385F, 389D, 401K, 402L, 458H, 461V, 471V, 472W, 473S, 474N, 477T
CDD
cd07302 (CHD)
nucleotidyl bindin...

907F

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

909S

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

910I

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

911P

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

912N

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

913F

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

914S

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

956K

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

958T

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

959G

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

960A

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

963M

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

1,030D

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

1,031I

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

1,032W

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

1,036V

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

1,037N

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

1,040S

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

1,041R

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)

1,077K

nucleotidyl binding site
907F, 909S, 910I, 911P, 912N, 913F, 914S, 956K, 958T, 959G, 960A, 963M, 1,030D, 1,031I, 1,032W, 1,036V, 1,037N, 1,040S, 1,041R, 1,077K
CDD
cd07302 (CHD)
metal binding site...

909S

metal binding site
909S, 960A
CDD
cd07302 (CHD)

960A

metal binding site
909S, 960A
CDD
cd07302 (CHD)
dimer interface cd...

914S

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

930L

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

933L

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

934N

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

937I

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

941D

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

956K

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

957S

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

1,018V

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

1,021V

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

1,031I

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

1,032W

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

1,033G

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

1,034N

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

1,037N

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

1,077K

dimer interface
914S, 930L, 933L, 934N, 937I, 941D, 956K, 957S, 1,018V, 1,021V, 1,031I, 1,032W, 1,033G, 1,034N, 1,037N, 1,077K
CDD
cd07302 (CHD)

GO term prediction

Biological Process

GO:0006171 cAMP biosynthetic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

Molecular Function

GO:0004016 adenylate cyclase activity
GO:0016849 phosphorus-oxygen lyase activity

Cellular Component

GO:0005886 plasma membrane

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Entry type

Status

Per-residue features