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Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= fbS20034
         (519 letters)

Database: human 
           237,096 sequences; 76,859,062 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

J04031-1|AAA59574.1|  935|Homo sapiens MTHFD protein.                  99   5e-21
BC050420-1|AAH50420.1|  935|Homo sapiens methylenetetrahydrofola...    99   5e-21
BC009806-1|AAH09806.1|  935|Homo sapiens methylenetetrahydrofola...    99   5e-21
X16396-1|CAA34431.1|  344|Homo sapiens protein ( Human mRNA for ...    71   3e-12
BC017054-1|AAH17054.2|  350|Homo sapiens methylenetetrahydrofola...    71   3e-12
BC015062-1|AAH15062.1|  248|Homo sapiens methylenetetrahydrofola...    71   3e-12
BC001548-1|AAH01548.1|  344|Homo sapiens methylene tetrahydrofol...    71   3e-12
AK223041-1|BAD96761.1|  344|Homo sapiens methylene tetrahydrofol...    71   3e-12
AK222826-1|BAD96546.1|  344|Homo sapiens methylene tetrahydrofol...    71   3e-12
AC073263-5|AAX93061.1|  344|Homo sapiens unknown protein.              71   3e-12
BC032771-1|AAH32771.1|  146|Homo sapiens MTHFD2L protein protein.      57   4e-08
BC110319-1|AAI10320.1|  900|Homo sapiens MTHFD1L protein protein.      51   2e-06
AY374131-1|AAQ82697.1|  275|Homo sapiens truncated C1-tetrahydro...    51   2e-06
AY374130-1|AAQ82696.1|  978|Homo sapiens C1-tetrahydrofolate syn...    51   2e-06
AL133260-2|CAI95678.1|  978|Homo sapiens methylenetetrahydrofola...    51   2e-06
AL117452-1|CAB55934.1|  917|Homo sapiens hypothetical protein pr...    51   2e-06
AL049694-3|CAI95774.1|  978|Homo sapiens methylenetetrahydrofola...    51   2e-06
AL035086-7|CAI42794.1|  978|Homo sapiens methylenetetrahydrofola...    51   2e-06
AL035086-6|CAI42793.1|  114|Homo sapiens methylenetetrahydrofola...    51   2e-06
AB127387-1|BAD93193.1|  978|Homo sapiens mitochondrial C1-tetrah...    51   2e-06
AL049694-4|CAI95775.1|  331|Homo sapiens methylenetetrahydrofola...    47   5e-05
AL035086-8|CAI42795.1|  331|Homo sapiens methylenetetrahydrofola...    47   5e-05
AK023167-1|BAB14441.1|  236|Homo sapiens ohydrolase (EC 1.5.1.15...    45   1e-04
BC037529-1|AAH37529.2|  106|Homo sapiens MTHFD2L protein protein.      42   0.001
AL035086-4|CAI42792.1|  120|Homo sapiens methylenetetrahydrofola...    42   0.001
AL035086-5|CAI42791.1|  120|Homo sapiens methylenetetrahydrofola...    38   0.028

>J04031-1|AAA59574.1|  935|Homo sapiens MTHFD protein.
          Length = 935

 Score =   99 bits (238), Expect = 5e-21
 Identities = 45/88 (51%), Positives = 66/88 (75%), Gaps = 1/88 (1%)
 Frame = +2

Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
           ++++  ITSLNE  +VHG +VQ+P  S+++ +   V +A++P+KDVDGL +IN GR+  G
Sbjct: 79  SEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARG 138

Query: 431 DLSG-XIPCTPAGCVELIXKTGVTIAGK 511
           DL+   IPCTP GC+ELI +TGV IAG+
Sbjct: 139 DLNDCFIPCTPKGCLELIKETGVPIAGR 166



 Score = 90.6 bits (215), Expect = 3e-18
 Identities = 43/75 (57%), Positives = 57/75 (76%)
 Frame = +3

Query: 27  AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
           A+I++G E++  I   L+ QVT+L+ +  GF PRLAI+QVG R DSN+YI +KLKAAE+I
Sbjct: 4   AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63

Query: 207 GIAAEHIRLPRDITE 251
           GI A HI+LPR  TE
Sbjct: 64  GIKATHIKLPRTTTE 78


>BC050420-1|AAH50420.1|  935|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
           protein.
          Length = 935

 Score =   99 bits (238), Expect = 5e-21
 Identities = 45/88 (51%), Positives = 66/88 (75%), Gaps = 1/88 (1%)
 Frame = +2

Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
           ++++  ITSLNE  +VHG +VQ+P  S+++ +   V +A++P+KDVDGL +IN GR+  G
Sbjct: 79  SEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARG 138

Query: 431 DLSG-XIPCTPAGCVELIXKTGVTIAGK 511
           DL+   IPCTP GC+ELI +TGV IAG+
Sbjct: 139 DLNDCFIPCTPKGCLELIKETGVPIAGR 166



 Score = 90.6 bits (215), Expect = 3e-18
 Identities = 43/75 (57%), Positives = 57/75 (76%)
 Frame = +3

Query: 27  AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
           A+I++G E++  I   L+ QVT+L+ +  GF PRLAI+QVG R DSN+YI +KLKAAE+I
Sbjct: 4   AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63

Query: 207 GIAAEHIRLPRDITE 251
           GI A HI+LPR  TE
Sbjct: 64  GIKATHIKLPRTTTE 78


>BC009806-1|AAH09806.1|  935|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
           protein.
          Length = 935

 Score =   99 bits (238), Expect = 5e-21
 Identities = 45/88 (51%), Positives = 66/88 (75%), Gaps = 1/88 (1%)
 Frame = +2

Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
           ++++  ITSLNE  +VHG +VQ+P  S+++ +   V +A++P+KDVDGL +IN GR+  G
Sbjct: 79  SEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARG 138

Query: 431 DLSG-XIPCTPAGCVELIXKTGVTIAGK 511
           DL+   IPCTP GC+ELI +TGV IAG+
Sbjct: 139 DLNDCFIPCTPKGCLELIKETGVPIAGR 166



 Score = 90.6 bits (215), Expect = 3e-18
 Identities = 43/75 (57%), Positives = 57/75 (76%)
 Frame = +3

Query: 27  AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
           A+I++G E++  I   L+ QVT+L+ +  GF PRLAI+QVG R DSN+YI +KLKAAE+I
Sbjct: 4   AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63

Query: 207 GIAAEHIRLPRDITE 251
           GI A HI+LPR  TE
Sbjct: 64  GIKATHIKLPRTTTE 78


>X16396-1|CAA34431.1|  344|Homo sapiens protein ( Human mRNA for
           NAD-dependent methylene tetrahydrofolate  dehydrogenase
           cyclohydrolase (EC 1.5.1.15).  ).
          Length = 344

 Score = 70.5 bits (165), Expect = 3e-12
 Identities = 38/86 (44%), Positives = 53/86 (61%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +LL  I  LN   +V G++VQ+P   +H  D  R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162

Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
               +P TP G  E+I +TG+   GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188



 Score = 43.6 bits (98), Expect = 4e-04
 Identities = 25/75 (33%), Positives = 42/75 (56%)
 Frame = +3

Query: 27  AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
           A +ISG ++A  I+ ++RQ+V    +      P L+++ VG    S+ Y+  K +AA  +
Sbjct: 31  AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 89

Query: 207 GIAAEHIRLPRDITE 251
           GI +E I  P  I+E
Sbjct: 90  GINSETIMKPASISE 104


>BC017054-1|AAH17054.2|  350|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
           protein.
          Length = 350

 Score = 70.5 bits (165), Expect = 3e-12
 Identities = 38/86 (44%), Positives = 53/86 (61%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +LL  I  LN   +V G++VQ+P   +H  D  R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 112 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 168

Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
               +P TP G  E+I +TG+   GK
Sbjct: 169 QYSMLPATPWGVWEIIKRTGIPTLGK 194



 Score = 43.6 bits (98), Expect = 4e-04
 Identities = 25/75 (33%), Positives = 42/75 (56%)
 Frame = +3

Query: 27  AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
           A +ISG ++A  I+ ++RQ+V    +      P L+++ VG    S+ Y+  K +AA  +
Sbjct: 37  AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95

Query: 207 GIAAEHIRLPRDITE 251
           GI +E I  P  I+E
Sbjct: 96  GINSETIMKPASISE 110


>BC015062-1|AAH15062.1|  248|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
           protein.
          Length = 248

 Score = 70.5 bits (165), Expect = 3e-12
 Identities = 38/86 (44%), Positives = 53/86 (61%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +LL  I  LN   +V G++VQ+P   +H  D  R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 10  ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 66

Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
               +P TP G  E+I +TG+   GK
Sbjct: 67  QYSMLPATPWGVWEIIKRTGIPTLGK 92


>BC001548-1|AAH01548.1|  344|Homo sapiens methylene tetrahydrofolate
           dehydrogenase 2, precursor protein.
          Length = 344

 Score = 70.5 bits (165), Expect = 3e-12
 Identities = 38/86 (44%), Positives = 53/86 (61%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +LL  I  LN   +V G++VQ+P   +H  D  R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162

Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
               +P TP G  E+I +TG+   GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188



 Score = 43.6 bits (98), Expect = 4e-04
 Identities = 25/75 (33%), Positives = 42/75 (56%)
 Frame = +3

Query: 27  AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
           A +ISG ++A  I+ ++RQ+V    +      P L+++ VG    S+ Y+  K +AA  +
Sbjct: 31  AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 89

Query: 207 GIAAEHIRLPRDITE 251
           GI +E I  P  I+E
Sbjct: 90  GINSETIMKPASISE 104


>AK223041-1|BAD96761.1|  344|Homo sapiens methylene tetrahydrofolate
           dehydrogenase 2 precursor variant protein.
          Length = 344

 Score = 70.5 bits (165), Expect = 3e-12
 Identities = 38/86 (44%), Positives = 53/86 (61%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +LL  I  LN   +V G++VQ+P   +H  D  R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162

Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
               +P TP G  E+I +TG+   GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188



 Score = 41.9 bits (94), Expect = 0.001
 Identities = 25/75 (33%), Positives = 41/75 (54%)
 Frame = +3

Query: 27  AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
           A +ISG ++A  I+ ++RQ+V    +      P L+++ VG    S+ Y+  K +AA   
Sbjct: 31  AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVA 89

Query: 207 GIAAEHIRLPRDITE 251
           GI +E I  P  I+E
Sbjct: 90  GINSETIMKPASISE 104


>AK222826-1|BAD96546.1|  344|Homo sapiens methylene tetrahydrofolate
           dehydrogenase 2 precursor variant protein.
          Length = 344

 Score = 70.5 bits (165), Expect = 3e-12
 Identities = 38/86 (44%), Positives = 53/86 (61%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +LL  I  LN   +V G++VQ+P   +H  D  R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162

Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
               +P TP G  E+I +TG+   GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188



 Score = 41.9 bits (94), Expect = 0.001
 Identities = 24/75 (32%), Positives = 41/75 (54%)
 Frame = +3

Query: 27  AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
           A +ISG ++A  I+ ++RQ+V    +      P L+++  G    S+ Y+  K +AA  +
Sbjct: 31  AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILAGENPASHSYVLNKTRAAAVV 89

Query: 207 GIAAEHIRLPRDITE 251
           GI +E I  P  I+E
Sbjct: 90  GINSETIMKPASISE 104


>AC073263-5|AAX93061.1|  344|Homo sapiens unknown protein.
          Length = 344

 Score = 70.5 bits (165), Expect = 3e-12
 Identities = 38/86 (44%), Positives = 53/86 (61%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +LL  I  LN   +V G++VQ+P   +H  D  R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162

Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
               +P TP G  E+I +TG+   GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188



 Score = 43.6 bits (98), Expect = 4e-04
 Identities = 25/75 (33%), Positives = 42/75 (56%)
 Frame = +3

Query: 27  AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
           A +ISG ++A  I+ ++RQ+V    +      P L+++ VG    S+ Y+  K +AA  +
Sbjct: 31  AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 89

Query: 207 GIAAEHIRLPRDITE 251
           GI +E I  P  I+E
Sbjct: 90  GINSETIMKPASISE 104


>BC032771-1|AAH32771.1|  146|Homo sapiens MTHFD2L protein protein.
          Length = 146

 Score = 56.8 bits (131), Expect = 4e-08
 Identities = 30/74 (40%), Positives = 44/74 (59%)
 Frame = +2

Query: 290 PSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCTPAGC 469
           P V GI+VQ+P   DH  D   + + ++P+KDVDG + IN GR+ + D    IP T +  
Sbjct: 3   PRVSGILVQLPLP-DHV-DERTICNGIAPEKDVDGFHIINIGRLCL-DQHSLIPATASAV 59

Query: 470 VELIXKTGVTIAGK 511
            E+I +TG+   GK
Sbjct: 60  WEIIKRTGIQTFGK 73


>BC110319-1|AAI10320.1|  900|Homo sapiens MTHFD1L protein protein.
          Length = 900

 Score = 51.2 bits (117), Expect = 2e-06
 Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 61  EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 116

Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
                    A   +EL+ K+GV + GK
Sbjct: 117 AHECFVSPVAKAVIELLEKSGVNLDGK 143



 Score = 35.1 bits (77), Expect = 0.15
 Identities = 20/58 (34%), Positives = 32/58 (55%)
 Frame = +3

Query: 78  RQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
           ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D +E
Sbjct: 5   KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPDSSE 59


>AY374131-1|AAQ82697.1|  275|Homo sapiens truncated
           C1-tetrahydrofolate synthase protein.
          Length = 275

 Score = 51.2 bits (117), Expect = 2e-06
 Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194

Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
                    A   +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221



 Score = 35.5 bits (78), Expect = 0.11
 Identities = 22/63 (34%), Positives = 35/63 (55%)
 Frame = +3

Query: 63  IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
           I+N  ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D
Sbjct: 79  IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134

Query: 243 ITE 251
            +E
Sbjct: 135 SSE 137


>AY374130-1|AAQ82696.1|  978|Homo sapiens C1-tetrahydrofolate
           synthase protein.
          Length = 978

 Score = 51.2 bits (117), Expect = 2e-06
 Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194

Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
                    A   +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221



 Score = 35.5 bits (78), Expect = 0.11
 Identities = 22/63 (34%), Positives = 35/63 (55%)
 Frame = +3

Query: 63  IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
           I+N  ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D
Sbjct: 79  IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134

Query: 243 ITE 251
            +E
Sbjct: 135 SSE 137


>AL133260-2|CAI95678.1|  978|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1-like protein.
          Length = 978

 Score = 51.2 bits (117), Expect = 2e-06
 Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194

Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
                    A   +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221



 Score = 35.5 bits (78), Expect = 0.11
 Identities = 22/63 (34%), Positives = 35/63 (55%)
 Frame = +3

Query: 63  IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
           I+N  ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D
Sbjct: 79  IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134

Query: 243 ITE 251
            +E
Sbjct: 135 SSE 137


>AL117452-1|CAB55934.1|  917|Homo sapiens hypothetical protein
           protein.
          Length = 917

 Score = 51.2 bits (117), Expect = 2e-06
 Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 78  EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 133

Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
                    A   +EL+ K+GV + GK
Sbjct: 134 AHECFVSPVAKAVIELLEKSGVNLDGK 160



 Score = 35.5 bits (78), Expect = 0.11
 Identities = 22/63 (34%), Positives = 35/63 (55%)
 Frame = +3

Query: 63  IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
           I+N  ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D
Sbjct: 18  IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 73

Query: 243 ITE 251
            +E
Sbjct: 74  SSE 76


>AL049694-3|CAI95774.1|  978|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1-like protein.
          Length = 978

 Score = 51.2 bits (117), Expect = 2e-06
 Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194

Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
                    A   +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221



 Score = 35.5 bits (78), Expect = 0.11
 Identities = 22/63 (34%), Positives = 35/63 (55%)
 Frame = +3

Query: 63  IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
           I+N  ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D
Sbjct: 79  IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134

Query: 243 ITE 251
            +E
Sbjct: 135 SSE 137


>AL035086-7|CAI42794.1|  978|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1-like protein.
          Length = 978

 Score = 51.2 bits (117), Expect = 2e-06
 Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194

Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
                    A   +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221



 Score = 35.5 bits (78), Expect = 0.11
 Identities = 22/63 (34%), Positives = 35/63 (55%)
 Frame = +3

Query: 63  IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
           I+N  ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D
Sbjct: 79  IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134

Query: 243 ITE 251
            +E
Sbjct: 135 SSE 137


>AL035086-6|CAI42793.1|  114|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1-like protein.
          Length = 114

 Score = 51.2 bits (117), Expect = 2e-06
 Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 29  EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 84

Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
                    A   +EL+ K+GV + GK
Sbjct: 85  AHECFVSPVAKAVIELLEKSGVNLDGK 111


>AB127387-1|BAD93193.1|  978|Homo sapiens mitochondrial
           C1-tetrahydrofolate synthetase protein.
          Length = 978

 Score = 51.2 bits (117), Expect = 2e-06
 Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194

Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
                    A   +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221



 Score = 35.5 bits (78), Expect = 0.11
 Identities = 22/63 (34%), Positives = 35/63 (55%)
 Frame = +3

Query: 63  IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
           I+N  ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D
Sbjct: 79  IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134

Query: 243 ITE 251
            +E
Sbjct: 135 SSE 137


>AL049694-4|CAI95775.1|  331|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1-like protein.
          Length = 331

 Score = 46.8 bits (106), Expect = 5e-05
 Identities = 29/88 (32%), Positives = 52/88 (59%), Gaps = 2/88 (2%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 98  EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 153

Query: 434 LSGXIPCTPA-GCVELIXKT-GVTIAGK 511
                    A   +EL+ K+ GV + GK
Sbjct: 154 AHECFVSPVAKAVIELLEKSVGVNLDGK 181



 Score = 35.5 bits (78), Expect = 0.11
 Identities = 22/63 (34%), Positives = 35/63 (55%)
 Frame = +3

Query: 63  IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
           I+N  ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D
Sbjct: 38  IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 93

Query: 243 ITE 251
            +E
Sbjct: 94  SSE 96


>AL035086-8|CAI42795.1|  331|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1-like protein.
          Length = 331

 Score = 46.8 bits (106), Expect = 5e-05
 Identities = 29/88 (32%), Positives = 52/88 (59%), Gaps = 2/88 (2%)
 Frame = +2

Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
           +++ +I  +NE   VHG+ +Q+   S++   +++V +A+ P+KDVDG+  IN G++  GD
Sbjct: 98  EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 153

Query: 434 LSGXIPCTPA-GCVELIXKT-GVTIAGK 511
                    A   +EL+ K+ GV + GK
Sbjct: 154 AHECFVSPVAKAVIELLEKSVGVNLDGK 181



 Score = 35.5 bits (78), Expect = 0.11
 Identities = 22/63 (34%), Positives = 35/63 (55%)
 Frame = +3

Query: 63  IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
           I+N  ++ ++ L+ K   F+P LAI+Q G   D N+   +    AE+ G+   HI LP D
Sbjct: 38  IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 93

Query: 243 ITE 251
            +E
Sbjct: 94  SSE 96


>AK023167-1|BAB14441.1|  236|Homo sapiens ohydrolase (EC 1.5.1.15). 
           protein.
          Length = 236

 Score = 45.2 bits (102), Expect = 1e-04
 Identities = 21/56 (37%), Positives = 33/56 (58%)
 Frame = +2

Query: 344 DAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCTPAGCVELIXKTGVTIAGK 511
           D   + + ++P+KDVDG + IN GR+ + D    IP T +   E+I +TG+   GK
Sbjct: 43  DERTICNGIAPEKDVDGFHIINIGRLCL-DQHSLIPATASAVWEIIKRTGIQTFGK 97


>BC037529-1|AAH37529.2|  106|Homo sapiens MTHFD2L protein protein.
          Length = 106

 Score = 41.9 bits (94), Expect = 0.001
 Identities = 17/43 (39%), Positives = 29/43 (67%)
 Frame = +3

Query: 123 PRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
           P L+I+ VG    S+ Y+R K++AA  +GI +E I  P+D+++
Sbjct: 24  PHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPKDVSQ 66


>AL035086-4|CAI42792.1|  120|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1-like protein.
          Length = 120

 Score = 41.9 bits (94), Expect = 0.001
 Identities = 21/56 (37%), Positives = 34/56 (60%), Gaps = 1/56 (1%)
 Frame = +2

Query: 347 AHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCTPA-GCVELIXKTGVTIAGK 511
           +++V +A+ P+KDVDG+  IN G++  GD         A   +EL+ K+GV + GK
Sbjct: 11  SNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGK 66


>AL035086-5|CAI42791.1|  120|Homo sapiens methylenetetrahydrofolate
           dehydrogenase (NADP+ dependent) 1-like protein.
          Length = 120

 Score = 37.5 bits (83), Expect = 0.028
 Identities = 21/57 (36%), Positives = 34/57 (59%), Gaps = 2/57 (3%)
 Frame = +2

Query: 347 AHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCTPA-GCVELIXKT-GVTIAGK 511
           +++V +A+ P+KDVDG+  IN G++  GD         A   +EL+ K+ GV + GK
Sbjct: 10  SNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSVGVNLDGK 66


  Database: human
    Posted date:  Oct 23, 2007  1:18 PM
  Number of letters in database: 76,859,062
  Number of sequences in database:  237,096
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 63,707,558
Number of Sequences: 237096
Number of extensions: 1092535
Number of successful extensions: 3389
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 3276
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3366
length of database: 76,859,062
effective HSP length: 85
effective length of database: 56,705,902
effective search space used: 4933413474
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)

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