Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= brP-2010
(828 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein. 182 2e-45
M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein. 182 2e-45
M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein. 182 2e-45
CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein. 182 2e-45
BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal ... 182 2e-45
BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal ... 182 2e-45
BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein. 182 2e-45
BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic pepti... 181 3e-45
AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4 pro... 181 3e-45
AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor prot... 181 3e-45
AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein. 181 3e-45
M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein. 174 3e-43
J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein. 174 3e-43
BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein. 174 3e-43
BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein. 174 3e-43
AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein. 174 3e-43
BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein. 171 2e-42
AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3 pro... 171 2e-42
X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mR... 151 4e-36
M10152-1|AAD03461.1| 406|Homo sapiens renin protein. 150 7e-36
L00073-1|AAA60363.1| 406|Homo sapiens renin protein. 150 7e-36
CR536498-1|CAG38737.1| 406|Homo sapiens REN protein. 150 7e-36
BC047752-1|AAH47752.1| 406|Homo sapiens renin protein. 150 7e-36
BC033474-1|AAH33474.1| 406|Homo sapiens renin protein. 150 7e-36
AL592146-1|CAI16594.1| 406|Homo sapiens renin protein. 150 7e-36
AL592114-1|CAH71224.1| 406|Homo sapiens renin protein. 150 7e-36
AY436324-1|AAR03502.1| 403|Homo sapiens renin protein. 149 1e-35
M26901-1|AAA60364.1| 403|Homo sapiens renin protein. 147 4e-35
M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein. 144 3e-34
J00287-1|AAA98529.1| 388|Homo sapiens PEP protein. 144 3e-34
BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I (... 144 3e-34
U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein. 142 1e-33
M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein. 142 1e-33
M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein. 142 1e-33
J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein. 142 1e-33
BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinog... 142 1e-33
AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinog... 142 1e-33
BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein. 111 4e-24
AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternativ... 111 4e-24
AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinog... 60 7e-09
AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens ... 52 2e-06
AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein. 52 3e-06
BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving ... 50 1e-05
AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein. 50 1e-05
AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving ... 50 1e-05
AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein. 50 1e-05
AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic ... 50 1e-05
AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1 pro... 50 1e-05
AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein. 50 1e-05
AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein. 50 1e-05
AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein. 50 1e-05
AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease ... 50 1e-05
AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein. 50 1e-05
DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving ... 46 1e-04
BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving ... 46 1e-04
BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving ... 46 1e-04
AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic ... 46 1e-04
AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase prot... 46 1e-04
AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2 pro... 46 1e-04
AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein. 46 1e-04
AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving ... 46 1e-04
AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant... 46 1e-04
AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein. 46 1e-04
AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein. 33 0.95
D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein. 32 2.9
AK126456-1|BAC86557.1| 199|Homo sapiens protein ( Homo sapiens ... 32 2.9
AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving ... 32 2.9
AC099344-1|AAY14825.1| 47|Homo sapiens unknown protein. 32 2.9
AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving ... 32 2.9
L12701-1|AAA53504.2| 333|Homo sapiens engrailed protein protein. 31 5.1
BC104972-1|AAI04973.1| 333|Homo sapiens engrailed homeobox 2 pr... 31 5.1
BC104970-1|AAI04971.1| 333|Homo sapiens engrailed homeobox 2 pr... 31 5.1
AC008060-1|AAQ96875.1| 333|Homo sapiens unknown protein. 31 5.1
>X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 182 bits (442), Expect = 2e-45
Identities = 92/202 (45%), Positives = 124/202 (61%), Gaps = 13/202 (6%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAF 148
SGSLSG+LS D V+V GG+KV RQ F EA +PG+ F+AAKFDGILGMA+
Sbjct: 144 SGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAY 203
Query: 149 STIAVDHVTPVFDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVP 325
I+V++V PVFDN++ LV Q +FSFYL+RDP A +D +Y+G L +
Sbjct: 204 PRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLN 263
Query: 326 LLRDTYWEFHMDSVNV-NASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFG 502
+ R YW+ H+D V V + C +GC AI DTGTSL+ GP EV L A+GA + G
Sbjct: 264 VTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQG 323
Query: 503 QYVVDCSLIPHLPRVTFTIAGK 568
+Y++ C + LP +T + GK
Sbjct: 324 EYMIPCEKVSTLPAITLKLGGK 345
Score = 36.7 bits (81), Expect = 0.10
Identities = 13/20 (65%), Positives = 16/20 (80%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G T+CLSGFM +D+P P GP
Sbjct: 362 GKTLCLSGFMGMDIPPPSGP 381
>M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 182 bits (442), Expect = 2e-45
Identities = 92/202 (45%), Positives = 124/202 (61%), Gaps = 13/202 (6%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAF 148
SGSLSG+LS D V+V GG+KV RQ F EA +PG+ F+AAKFDGILGMA+
Sbjct: 144 SGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAY 203
Query: 149 STIAVDHVTPVFDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVP 325
I+V++V PVFDN++ LV Q +FSFYL+RDP A +D +Y+G L +
Sbjct: 204 PRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLN 263
Query: 326 LLRDTYWEFHMDSVNV-NASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFG 502
+ R YW+ H+D V V + C +GC AI DTGTSL+ GP EV L A+GA + G
Sbjct: 264 VTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQG 323
Query: 503 QYVVDCSLIPHLPRVTFTIAGK 568
+Y++ C + LP +T + GK
Sbjct: 324 EYMIPCEKVSTLPAITLKLGGK 345
Score = 36.7 bits (81), Expect = 0.10
Identities = 13/20 (65%), Positives = 16/20 (80%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G T+CLSGFM +D+P P GP
Sbjct: 362 GKTLCLSGFMGMDIPPPSGP 381
>M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 182 bits (442), Expect = 2e-45
Identities = 92/202 (45%), Positives = 124/202 (61%), Gaps = 13/202 (6%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAF 148
SGSLSG+LS D V+V GG+KV RQ F EA +PG+ F+AAKFDGILGMA+
Sbjct: 144 SGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAY 203
Query: 149 STIAVDHVTPVFDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVP 325
I+V++V PVFDN++ LV Q +FSFYL+RDP A +D +Y+G L +
Sbjct: 204 PRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLN 263
Query: 326 LLRDTYWEFHMDSVNV-NASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFG 502
+ R YW+ H+D V V + C +GC AI DTGTSL+ GP EV L A+GA + G
Sbjct: 264 VTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQG 323
Query: 503 QYVVDCSLIPHLPRVTFTIAGK 568
+Y++ C + LP +T + GK
Sbjct: 324 EYMIPCEKVSTLPAITLKLGGK 345
Score = 36.7 bits (81), Expect = 0.10
Identities = 13/20 (65%), Positives = 16/20 (80%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G T+CLSGFM +D+P P GP
Sbjct: 362 GKTLCLSGFMGMDIPPPSGP 381
>CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 182 bits (442), Expect = 2e-45
Identities = 92/202 (45%), Positives = 124/202 (61%), Gaps = 13/202 (6%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAF 148
SGSLSG+LS D V+V GG+KV RQ F EA +PG+ F+AAKFDGILGMA+
Sbjct: 144 SGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAY 203
Query: 149 STIAVDHVTPVFDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVP 325
I+V++V PVFDN++ LV Q +FSFYL+RDP A +D +Y+G L +
Sbjct: 204 PRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLN 263
Query: 326 LLRDTYWEFHMDSVNV-NASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFG 502
+ R YW+ H+D V V + C +GC AI DTGTSL+ GP EV L A+GA + G
Sbjct: 264 VTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQG 323
Query: 503 QYVVDCSLIPHLPRVTFTIAGK 568
+Y++ C + LP +T + GK
Sbjct: 324 EYMIPCEKVSTLPAITLKLGGK 345
Score = 36.7 bits (81), Expect = 0.10
Identities = 13/20 (65%), Positives = 16/20 (80%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G T+CLSGFM +D+P P GP
Sbjct: 362 GKTLCLSGFMGMDIPPPSGP 381
>BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 182 bits (442), Expect = 2e-45
Identities = 92/202 (45%), Positives = 124/202 (61%), Gaps = 13/202 (6%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAF 148
SGSLSG+LS D V+V GG+KV RQ F EA +PG+ F+AAKFDGILGMA+
Sbjct: 144 SGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAY 203
Query: 149 STIAVDHVTPVFDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVP 325
I+V++V PVFDN++ LV Q +FSFYL+RDP A +D +Y+G L +
Sbjct: 204 PRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLN 263
Query: 326 LLRDTYWEFHMDSVNV-NASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFG 502
+ R YW+ H+D V V + C +GC AI DTGTSL+ GP EV L A+GA + G
Sbjct: 264 VTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQG 323
Query: 503 QYVVDCSLIPHLPRVTFTIAGK 568
+Y++ C + LP +T + GK
Sbjct: 324 EYMIPCEKVSTLPAITLKLGGK 345
Score = 36.7 bits (81), Expect = 0.10
Identities = 13/20 (65%), Positives = 16/20 (80%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G T+CLSGFM +D+P P GP
Sbjct: 362 GKTLCLSGFMGMDIPPPSGP 381
>BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 182 bits (442), Expect = 2e-45
Identities = 92/202 (45%), Positives = 124/202 (61%), Gaps = 13/202 (6%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAF 148
SGSLSG+LS D V+V GG+KV RQ F EA +PG+ F+AAKFDGILGMA+
Sbjct: 144 SGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAY 203
Query: 149 STIAVDHVTPVFDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVP 325
I+V++V PVFDN++ LV Q +FSFYL+RDP A +D +Y+G L +
Sbjct: 204 PRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLN 263
Query: 326 LLRDTYWEFHMDSVNV-NASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFG 502
+ R YW+ H+D V V + C +GC AI DTGTSL+ GP EV L A+GA + G
Sbjct: 264 VTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQG 323
Query: 503 QYVVDCSLIPHLPRVTFTIAGK 568
+Y++ C + LP +T + GK
Sbjct: 324 EYMIPCEKVSTLPAITLKLGGK 345
Score = 36.7 bits (81), Expect = 0.10
Identities = 13/20 (65%), Positives = 16/20 (80%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G T+CLSGFM +D+P P GP
Sbjct: 362 GKTLCLSGFMGMDIPPPSGP 381
>BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 182 bits (442), Expect = 2e-45
Identities = 92/202 (45%), Positives = 124/202 (61%), Gaps = 13/202 (6%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAF 148
SGSLSG+LS D V+V GG+KV RQ F EA +PG+ F+AAKFDGILGMA+
Sbjct: 144 SGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAY 203
Query: 149 STIAVDHVTPVFDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVP 325
I+V++V PVFDN++ LV Q +FSFYL+RDP A +D +Y+G L +
Sbjct: 204 PRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLN 263
Query: 326 LLRDTYWEFHMDSVNV-NASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFG 502
+ R YW+ H+D V V + C +GC AI DTGTSL+ GP EV L A+GA + G
Sbjct: 264 VTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQG 323
Query: 503 QYVVDCSLIPHLPRVTFTIAGK 568
+Y++ C + LP +T + GK
Sbjct: 324 EYMIPCEKVSTLPAITLKLGGK 345
Score = 36.7 bits (81), Expect = 0.10
Identities = 13/20 (65%), Positives = 16/20 (80%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G T+CLSGFM +D+P P GP
Sbjct: 362 GKTLCLSGFMGMDIPPPSGP 381
>BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic
peptidase protein.
Length = 420
Score = 181 bits (440), Expect = 3e-45
Identities = 89/190 (46%), Positives = 118/190 (62%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+ V P
Sbjct: 143 TGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPP 202
Query: 182 FDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
D +V GL+ +PVFSFYLNRDP SDPAHY L VP+ YW+ HM
Sbjct: 203 MDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHM 262
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
+ V V CA+GC+AI DTGTSLI GP++E+ AL+AA+G + G+Y++ CS IP
Sbjct: 263 ERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEIPK 322
Query: 536 LPRVTFTIAG 565
LP V+F + G
Sbjct: 323 LPAVSFLLGG 332
Score = 34.3 bits (75), Expect = 0.55
Identities = 14/20 (70%), Positives = 15/20 (75%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G +CLSGF ALDVP P GP
Sbjct: 350 GVRLCLSGFQALDVPPPAGP 369
>AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4
protein.
Length = 420
Score = 181 bits (440), Expect = 3e-45
Identities = 89/190 (46%), Positives = 118/190 (62%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+ V P
Sbjct: 143 TGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPP 202
Query: 182 FDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
D +V GL+ +PVFSFYLNRDP SDPAHY L VP+ YW+ HM
Sbjct: 203 MDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHM 262
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
+ V V CA+GC+AI DTGTSLI GP++E+ AL+AA+G + G+Y++ CS IP
Sbjct: 263 ERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEIPK 322
Query: 536 LPRVTFTIAG 565
LP V+F + G
Sbjct: 323 LPAVSFLLGG 332
Score = 34.3 bits (75), Expect = 0.55
Identities = 14/20 (70%), Positives = 15/20 (75%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G +CLSGF ALDVP P GP
Sbjct: 350 GVRLCLSGFQALDVPPPAGP 369
>AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor
protein.
Length = 420
Score = 181 bits (440), Expect = 3e-45
Identities = 89/190 (46%), Positives = 118/190 (62%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+ V P
Sbjct: 143 TGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPP 202
Query: 182 FDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
D +V GL+ +PVFSFYLNRDP SDPAHY L VP+ YW+ HM
Sbjct: 203 MDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHM 262
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
+ V V CA+GC+AI DTGTSLI GP++E+ AL+AA+G + G+Y++ CS IP
Sbjct: 263 ERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEIPK 322
Query: 536 LPRVTFTIAG 565
LP V+F + G
Sbjct: 323 LPAVSFLLGG 332
Score = 34.3 bits (75), Expect = 0.55
Identities = 14/20 (70%), Positives = 15/20 (75%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G +CLSGF ALDVP P GP
Sbjct: 350 GVRLCLSGFQALDVPPPAGP 369
>AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein.
Length = 420
Score = 181 bits (440), Expect = 3e-45
Identities = 89/190 (46%), Positives = 118/190 (62%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+ V P
Sbjct: 143 TGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPP 202
Query: 182 FDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
D +V GL+ +PVFSFYLNRDP SDPAHY L VP+ YW+ HM
Sbjct: 203 MDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHM 262
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
+ V V CA+GC+AI DTGTSLI GP++E+ AL+AA+G + G+Y++ CS IP
Sbjct: 263 ERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEIPK 322
Query: 536 LPRVTFTIAG 565
LP V+F + G
Sbjct: 323 LPAVSFLLGG 332
Score = 34.3 bits (75), Expect = 0.55
Identities = 14/20 (70%), Positives = 15/20 (75%)
Frame = +3
Query: 621 GHTVCLSGFMALDVPKPMGP 680
G +CLSGF ALDVP P GP
Sbjct: 350 GVRLCLSGFQALDVPPPAGP 369
>M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 174 bits (424), Expect = 3e-43
Identities = 86/190 (45%), Positives = 122/190 (64%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGILG+ + ++AV VTPV
Sbjct: 141 TGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPV 200
Query: 182 FDNMVAXGLVQ-PVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDNM+A LV P+FS Y++ +P D +H+ G L VP+ + YW+ +
Sbjct: 201 FDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIAL 260
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
D++ V + FC++GC AI DTGTSLI GPS +++ L A+GA + G+Y V+C+ +
Sbjct: 261 DNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVD-GEYAVECANLNV 319
Query: 536 LPRVTFTIAG 565
+P VTFTI G
Sbjct: 320 MPDVTFTING 329
>J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein.
Length = 396
Score = 174 bits (424), Expect = 3e-43
Identities = 86/190 (45%), Positives = 122/190 (64%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGILG+ + ++AV VTPV
Sbjct: 141 TGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPV 200
Query: 182 FDNMVAXGLVQ-PVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDNM+A LV P+FS Y++ +P D +H+ G L VP+ + YW+ +
Sbjct: 201 FDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIAL 260
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
D++ V + FC++GC AI DTGTSLI GPS +++ L A+GA + G+Y V+C+ +
Sbjct: 261 DNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVD-GEYAVECANLNV 319
Query: 536 LPRVTFTIAG 565
+P VTFTI G
Sbjct: 320 MPDVTFTING 329
>BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 174 bits (424), Expect = 3e-43
Identities = 86/190 (45%), Positives = 122/190 (64%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGILG+ + ++AV VTPV
Sbjct: 141 TGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPV 200
Query: 182 FDNMVAXGLVQ-PVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDNM+A LV P+FS Y++ +P D +H+ G L VP+ + YW+ +
Sbjct: 201 FDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIAL 260
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
D++ V + FC++GC AI DTGTSLI GPS +++ L A+GA + G+Y V+C+ +
Sbjct: 261 DNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVD-GEYAVECANLNV 319
Query: 536 LPRVTFTIAG 565
+P VTFTI G
Sbjct: 320 MPDVTFTING 329
>BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 174 bits (424), Expect = 3e-43
Identities = 86/190 (45%), Positives = 122/190 (64%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGILG+ + ++AV VTPV
Sbjct: 141 TGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPV 200
Query: 182 FDNMVAXGLVQ-PVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDNM+A LV P+FS Y++ +P D +H+ G L VP+ + YW+ +
Sbjct: 201 FDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIAL 260
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
D++ V + FC++GC AI DTGTSLI GPS +++ L A+GA + G+Y V+C+ +
Sbjct: 261 DNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVD-GEYAVECANLNV 319
Query: 536 LPRVTFTIAG 565
+P VTFTI G
Sbjct: 320 MPDVTFTING 329
>AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein.
Length = 396
Score = 174 bits (424), Expect = 3e-43
Identities = 86/190 (45%), Positives = 122/190 (64%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGILG+ + ++AV VTPV
Sbjct: 141 TGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPV 200
Query: 182 FDNMVAXGLVQ-PVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDNM+A LV P+FS Y++ +P D +H+ G L VP+ + YW+ +
Sbjct: 201 FDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIAL 260
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
D++ V + FC++GC AI DTGTSLI GPS +++ L A+GA + G+Y V+C+ +
Sbjct: 261 DNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVD-GEYAVECANLNV 319
Query: 536 LPRVTFTIAG 565
+P VTFTI G
Sbjct: 320 MPDVTFTING 329
>BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein.
Length = 464
Score = 171 bits (417), Expect = 2e-42
Identities = 84/190 (44%), Positives = 115/190 (60%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G + G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P
Sbjct: 139 TGRVDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPP 198
Query: 182 FDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
D +V GL+ +PVFSFY NRDP SDPAHY L VP+ YW+ HM
Sbjct: 199 LDVLVEQGLLDKPVFSFYFNRDPEVADGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHM 258
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
+ V V + CAQGC+AI DTGT +I GP++E+ AL+AA+G + G+Y++ CS IP
Sbjct: 259 ERVKVGSRLTLCAQGCAAILDTGTPVIVGPTEEIRALHAAIGGIPLLAGEYIIRCSEIPK 318
Query: 536 LPRVTFTIAG 565
LP V+ I G
Sbjct: 319 LPAVSLLIGG 328
>AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3
protein.
Length = 450
Score = 171 bits (417), Expect = 2e-42
Identities = 84/190 (44%), Positives = 115/190 (60%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G + G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P
Sbjct: 143 TGRVDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPP 202
Query: 182 FDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
D +V GL+ +PVFSFY NRDP SDPAHY L VP+ YW+ HM
Sbjct: 203 LDVLVEQGLLDKPVFSFYFNRDPEVADGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHM 262
Query: 359 DSVNVNAS-RFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
+ V V + CAQGC+AI DTGT +I GP++E+ AL+AA+G + G+Y++ CS IP
Sbjct: 263 ERVKVGSRLTLCAQGCAAILDTGTPVIVGPTEEIRALHAAIGGIPLLAGEYIIRCSEIPK 322
Query: 536 LPRVTFTIAG 565
LP V+ I G
Sbjct: 323 LPAVSLLIGG 332
>X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mRNA
fragment for renin (aa 105-401). ).
Length = 300
Score = 151 bits (365), Expect = 4e-36
Identities = 78/193 (40%), Positives = 112/193 (58%), Gaps = 4/193 (2%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 44 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPI 102
Query: 182 FDNMVAXGLV-QPVFSFYLNRDP--GATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEF 352
FDN+++ G++ + VFSFY NRD + SDP HY G+ + L++ W+
Sbjct: 103 FDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI 162
Query: 353 HMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLI 529
M V+V +S C GC A+ DTG S I+G + +E L A+GA YVV C+
Sbjct: 163 QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKEKRLFDYVVKCNEG 222
Query: 530 PHLPRVTFTIAGK 568
P LP ++F + GK
Sbjct: 223 PTLPDISFHLGGK 235
>M10152-1|AAD03461.1| 406|Homo sapiens renin protein.
Length = 406
Score = 150 bits (363), Expect = 7e-36
Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 4/193 (2%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 151 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPI 209
Query: 182 FDNMVAXG-LVQPVFSFYLNRDP--GATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEF 352
FDN+++ G L + VFSFY NRD + SDP HY G+ + L++ W+
Sbjct: 210 FDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI 269
Query: 353 HMDSVNVNASR-FCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLI 529
M V+V +S C GC A+ DTG S I+G + +E L A+GA F YVV C+
Sbjct: 270 QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEG 328
Query: 530 PHLPRVTFTIAGK 568
P LP ++F + GK
Sbjct: 329 PTLPDISFHLGGK 341
>L00073-1|AAA60363.1| 406|Homo sapiens renin protein.
Length = 406
Score = 150 bits (363), Expect = 7e-36
Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 4/193 (2%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 151 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPI 209
Query: 182 FDNMVAXG-LVQPVFSFYLNRDP--GATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEF 352
FDN+++ G L + VFSFY NRD + SDP HY G+ + L++ W+
Sbjct: 210 FDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI 269
Query: 353 HMDSVNVNASR-FCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLI 529
M V+V +S C GC A+ DTG S I+G + +E L A+GA F YVV C+
Sbjct: 270 QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEG 328
Query: 530 PHLPRVTFTIAGK 568
P LP ++F + GK
Sbjct: 329 PTLPDISFHLGGK 341
>CR536498-1|CAG38737.1| 406|Homo sapiens REN protein.
Length = 406
Score = 150 bits (363), Expect = 7e-36
Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 4/193 (2%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 151 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPI 209
Query: 182 FDNMVAXG-LVQPVFSFYLNRDP--GATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEF 352
FDN+++ G L + VFSFY NRD + SDP HY G+ + L++ W+
Sbjct: 210 FDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI 269
Query: 353 HMDSVNVNASR-FCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLI 529
M V+V +S C GC A+ DTG S I+G + +E L A+GA F YVV C+
Sbjct: 270 QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEG 328
Query: 530 PHLPRVTFTIAGK 568
P LP ++F + GK
Sbjct: 329 PTLPDISFHLGGK 341
>BC047752-1|AAH47752.1| 406|Homo sapiens renin protein.
Length = 406
Score = 150 bits (363), Expect = 7e-36
Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 4/193 (2%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 151 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPI 209
Query: 182 FDNMVAXG-LVQPVFSFYLNRDP--GATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEF 352
FDN+++ G L + VFSFY NRD + SDP HY G+ + L++ W+
Sbjct: 210 FDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI 269
Query: 353 HMDSVNVNASR-FCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLI 529
M V+V +S C GC A+ DTG S I+G + +E L A+GA F YVV C+
Sbjct: 270 QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEG 328
Query: 530 PHLPRVTFTIAGK 568
P LP ++F + GK
Sbjct: 329 PTLPDISFHLGGK 341
>BC033474-1|AAH33474.1| 406|Homo sapiens renin protein.
Length = 406
Score = 150 bits (363), Expect = 7e-36
Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 4/193 (2%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 151 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPI 209
Query: 182 FDNMVAXG-LVQPVFSFYLNRDP--GATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEF 352
FDN+++ G L + VFSFY NRD + SDP HY G+ + L++ W+
Sbjct: 210 FDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI 269
Query: 353 HMDSVNVNASR-FCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLI 529
M V+V +S C GC A+ DTG S I+G + +E L A+GA F YVV C+
Sbjct: 270 QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEG 328
Query: 530 PHLPRVTFTIAGK 568
P LP ++F + GK
Sbjct: 329 PTLPDISFHLGGK 341
>AL592146-1|CAI16594.1| 406|Homo sapiens renin protein.
Length = 406
Score = 150 bits (363), Expect = 7e-36
Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 4/193 (2%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 151 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPI 209
Query: 182 FDNMVAXG-LVQPVFSFYLNRDP--GATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEF 352
FDN+++ G L + VFSFY NRD + SDP HY G+ + L++ W+
Sbjct: 210 FDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI 269
Query: 353 HMDSVNVNASR-FCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLI 529
M V+V +S C GC A+ DTG S I+G + +E L A+GA F YVV C+
Sbjct: 270 QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEG 328
Query: 530 PHLPRVTFTIAGK 568
P LP ++F + GK
Sbjct: 329 PTLPDISFHLGGK 341
>AL592114-1|CAH71224.1| 406|Homo sapiens renin protein.
Length = 406
Score = 150 bits (363), Expect = 7e-36
Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 4/193 (2%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 151 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPI 209
Query: 182 FDNMVAXG-LVQPVFSFYLNRDP--GATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEF 352
FDN+++ G L + VFSFY NRD + SDP HY G+ + L++ W+
Sbjct: 210 FDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI 269
Query: 353 HMDSVNVNASR-FCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLI 529
M V+V +S C GC A+ DTG S I+G + +E L A+GA F YVV C+
Sbjct: 270 QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEG 328
Query: 530 PHLPRVTFTIAGK 568
P LP ++F + GK
Sbjct: 329 PTLPDISFHLGGK 341
>AY436324-1|AAR03502.1| 403|Homo sapiens renin protein.
Length = 403
Score = 149 bits (361), Expect = 1e-35
Identities = 79/191 (41%), Positives = 112/191 (58%), Gaps = 2/191 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 151 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPI 209
Query: 182 FDNMVAXG-LVQPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDN+++ G L + VFSFY NR+ + SDP HY G+ + L++ W+ M
Sbjct: 210 FDNIISQGVLKEDVFSFYYNRN-SQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQM 268
Query: 359 DSVNVNASR-FCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
V+V +S C GC A+ DTG S I+G + +E L A+GA F YVV C+ P
Sbjct: 269 KGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEGPT 327
Query: 536 LPRVTFTIAGK 568
LP ++F + GK
Sbjct: 328 LPDISFHLGGK 338
>M26901-1|AAA60364.1| 403|Homo sapiens renin protein.
Length = 403
Score = 147 bits (357), Expect = 4e-35
Identities = 79/191 (41%), Positives = 112/191 (58%), Gaps = 2/191 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM F A+ VTP+
Sbjct: 151 TGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAQFDGVVGMGFIEQAIGRVTPI 209
Query: 182 FDNMVAXG-LVQPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDN+++ G L + VFSFY NR+ + SDP HY G+ + L++ W+ M
Sbjct: 210 FDNIISQGVLKEDVFSFYYNRN-SQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQM 268
Query: 359 DSVNVNASR-FCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
V+V +S C GC A+ DTG S I+G + +E L A+GA F YVV C+ P
Sbjct: 269 KGVSVGSSTLLCEDGCLALVDTGASYISGSTSCIEKLMEALGAKKRLF-DYVVKCNEGPT 327
Query: 536 LPRVTFTIAGK 568
LP ++F + GK
Sbjct: 328 LPDISFHLGGK 338
>M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein.
Length = 388
Score = 144 bits (350), Expect = 3e-34
Identities = 77/190 (40%), Positives = 110/190 (57%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GS++G L D V VGG+ Q F + +EPG A FDGILG+A+ +I+ TPV
Sbjct: 139 TGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPV 198
Query: 182 FDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDN+ GLV Q +FS YL+ D + + D ++Y G L VP+ + YW+ +
Sbjct: 199 FDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGI--DSSYYTGSLNWVPVTVEGYWQITV 256
Query: 359 DSVNVNASRF-CAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
DS+ +N CA+GC AI DTGTSL+ GP+ + + + +GA+ + G VV CS I
Sbjct: 257 DSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISS 316
Query: 536 LPRVTFTIAG 565
LP + FTI G
Sbjct: 317 LPDIVFTING 326
>J00287-1|AAA98529.1| 388|Homo sapiens PEP protein.
Length = 388
Score = 144 bits (350), Expect = 3e-34
Identities = 77/190 (40%), Positives = 110/190 (57%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GS++G L D V VGG+ Q F + +EPG A FDGILG+A+ +I+ TPV
Sbjct: 139 TGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPV 198
Query: 182 FDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDN+ GLV Q +FS YL+ D + + D ++Y G L VP+ + YW+ +
Sbjct: 199 FDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGI--DSSYYTGSLNWVPVTVEGYWQITV 256
Query: 359 DSVNVNASRF-CAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
DS+ +N CA+GC AI DTGTSL+ GP+ + + + +GA+ + G VV CS I
Sbjct: 257 DSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISS 316
Query: 536 LPRVTFTIAG 565
LP + FTI G
Sbjct: 317 LPDIVFTING 326
>BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I
(pepsinogen A) protein.
Length = 388
Score = 144 bits (350), Expect = 3e-34
Identities = 77/190 (40%), Positives = 110/190 (57%), Gaps = 2/190 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GS++G L D V VGG+ Q F + +EPG A FDGILG+A+ +I+ TPV
Sbjct: 139 TGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPV 198
Query: 182 FDNMVAXGLV-QPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDN+ GLV Q +FS YL+ D + + D ++Y G L VP+ + YW+ +
Sbjct: 199 FDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGI--DSSYYTGSLNWVPVTVEGYWQITV 256
Query: 359 DSVNVNASRF-CAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPH 535
DS+ +N CA+GC AI DTGTSL+ GP+ + + + +GA+ + G VV CS I
Sbjct: 257 DSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISS 316
Query: 536 LPRVTFTIAG 565
LP + FTI G
Sbjct: 317 LPDIVFTING 326
>U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein.
Length = 388
Score = 142 bits (345), Expect = 1e-33
Identities = 74/191 (38%), Positives = 111/191 (58%), Gaps = 3/191 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
SGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 136 SGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTA 195
Query: 182 FDNMVAXG-LVQPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
MV G L PVFS YL+ G++ D + Y G + P+ ++ YW+ +
Sbjct: 196 MQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGV-DSSLYTGQIYWAPVTQELYWQIGI 254
Query: 359 DS--VNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIP 532
+ + AS +C++GC AI DTGTSL+ P + + AL A GA +GQ++V+C+ I
Sbjct: 255 EEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQ 314
Query: 533 HLPRVTFTIAG 565
+LP +TF I G
Sbjct: 315 NLPSLTFIING 325
>M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein.
Length = 388
Score = 142 bits (345), Expect = 1e-33
Identities = 74/191 (38%), Positives = 111/191 (58%), Gaps = 3/191 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
SGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 136 SGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTA 195
Query: 182 FDNMVAXG-LVQPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
MV G L PVFS YL+ G++ D + Y G + P+ ++ YW+ +
Sbjct: 196 MQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGV-DSSLYTGQIYWAPVTQELYWQIGI 254
Query: 359 DS--VNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIP 532
+ + AS +C++GC AI DTGTSL+ P + + AL A GA +GQ++V+C+ I
Sbjct: 255 EEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQ 314
Query: 533 HLPRVTFTIAG 565
+LP +TF I G
Sbjct: 315 NLPSLTFIING 325
>M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein.
Length = 385
Score = 142 bits (345), Expect = 1e-33
Identities = 74/191 (38%), Positives = 111/191 (58%), Gaps = 3/191 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
SGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 133 SGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTA 192
Query: 182 FDNMVAXG-LVQPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
MV G L PVFS YL+ G++ D + Y G + P+ ++ YW+ +
Sbjct: 193 MQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGV-DSSLYTGQIYWAPVTQELYWQIGI 251
Query: 359 DS--VNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIP 532
+ + AS +C++GC AI DTGTSL+ P + + AL A GA +GQ++V+C+ I
Sbjct: 252 EEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQ 311
Query: 533 HLPRVTFTIAG 565
+LP +TF I G
Sbjct: 312 NLPSLTFIING 322
>J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein.
Length = 388
Score = 142 bits (345), Expect = 1e-33
Identities = 74/191 (38%), Positives = 111/191 (58%), Gaps = 3/191 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
SGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 136 SGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTA 195
Query: 182 FDNMVAXG-LVQPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
MV G L PVFS YL+ G++ D + Y G + P+ ++ YW+ +
Sbjct: 196 MQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGV-DSSLYTGQIYWAPVTQELYWQIGI 254
Query: 359 DS--VNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIP 532
+ + AS +C++GC AI DTGTSL+ P + + AL A GA +GQ++V+C+ I
Sbjct: 255 EEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQ 314
Query: 533 HLPRVTFTIAG 565
+LP +TF I G
Sbjct: 315 NLPSLTFIING 325
>BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 142 bits (345), Expect = 1e-33
Identities = 74/191 (38%), Positives = 111/191 (58%), Gaps = 3/191 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
SGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 136 SGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTA 195
Query: 182 FDNMVAXG-LVQPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
MV G L PVFS YL+ G++ D + Y G + P+ ++ YW+ +
Sbjct: 196 MQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGV-DSSLYTGQIYWAPVTQELYWQIGI 254
Query: 359 DS--VNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIP 532
+ + AS +C++GC AI DTGTSL+ P + + AL A GA +GQ++V+C+ I
Sbjct: 255 EEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQ 314
Query: 533 HLPRVTFTIAG 565
+LP +TF I G
Sbjct: 315 NLPSLTFIING 325
>AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 142 bits (345), Expect = 1e-33
Identities = 74/191 (38%), Positives = 111/191 (58%), Gaps = 3/191 (1%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
SGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 136 SGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTA 195
Query: 182 FDNMVAXG-LVQPVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
MV G L PVFS YL+ G++ D + Y G + P+ ++ YW+ +
Sbjct: 196 MQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGV-DSSLYTGQIYWAPVTQELYWQIGI 254
Query: 359 DS--VNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIP 532
+ + AS +C++GC AI DTGTSL+ P + + AL A GA +GQ++V+C+ I
Sbjct: 255 EEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQ 314
Query: 533 HLPRVTFTIAG 565
+LP +TF I G
Sbjct: 315 NLPSLTFIING 325
>BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein.
Length = 363
Score = 111 bits (266), Expect = 4e-24
Identities = 54/123 (43%), Positives = 77/123 (62%), Gaps = 1/123 (0%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGILG+ + ++AV VTPV
Sbjct: 141 TGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPV 200
Query: 182 FDNMVAXGLVQ-PVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDNM+A LV P+FS Y++ +P D +H+ G L VP+ + YW+ +
Sbjct: 201 FDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIAL 260
Query: 359 DSV 367
D++
Sbjct: 261 DNM 263
>AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternative
protein.
Length = 363
Score = 111 bits (266), Expect = 4e-24
Identities = 54/123 (43%), Positives = 77/123 (62%), Gaps = 1/123 (0%)
Frame = +2
Query: 2 SGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPV 181
+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGILG+ + ++AV VTPV
Sbjct: 141 TGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPV 200
Query: 182 FDNMVAXGLVQ-PVFSFYLNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHM 358
FDNM+A LV P+FS Y++ +P D +H+ G L VP+ + YW+ +
Sbjct: 201 FDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIAL 260
Query: 359 DSV 367
D++
Sbjct: 261 DNM 263
>AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 140
Score = 60.5 bits (140), Expect = 7e-09
Identities = 30/70 (42%), Positives = 41/70 (58%), Gaps = 1/70 (1%)
Frame = +2
Query: 44 VGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDNMVAXG-LVQPV 220
V ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T MV G L PV
Sbjct: 71 VQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPV 130
Query: 221 FSFYLNRDPG 250
FS YL+ G
Sbjct: 131 FSVYLSNQQG 140
>AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens
cDNA PSEC0239 fis, clone OVARC1000363, highly similar to
Homo sapiens aspartyl protease mRNA. ).
Length = 423
Score = 52.4 bits (120), Expect = 2e-06
Identities = 47/180 (26%), Positives = 84/180 (46%), Gaps = 17/180 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E G F+ +++GILG+A++T+A +
Sbjct: 57 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESGNFFLPGIQWNGILGLAYATLAKPSSSL 116
Query: 173 TPVFDNMVAXGLVQPVFSFYLNRDPG------ATTXXXXXXXXSDPAHYRGDLVRVPLLR 334
FD++V + VFS + R G T +P+ Y+GD+ P+
Sbjct: 117 ETFFDSLVTQANIPNVFSMQM-RGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKE 175
Query: 335 DTYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
+ Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 176 EWYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 233
>AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein.
Length = 468
Score = 51.6 bits (118), Expect = 3e-06
Identities = 48/190 (25%), Positives = 86/190 (45%), Gaps = 16/190 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIA 496
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASLL 329
Query: 497 FGQYVVDCSL 526
+ Q ++ L
Sbjct: 330 YIQPMMGAGL 339
>BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving
enzyme 2 protein.
Length = 518
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 328
>AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein.
Length = 518
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 328
>AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving
enzyme 2, EC 3.4.23. protein.
Length = 415
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 49 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 108
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 109 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 168
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 169 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 225
>AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein.
Length = 439
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 73 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 132
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 133 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 192
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 193 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 249
>AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic
proteinase Asp 1 protein.
Length = 518
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 328
>AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1
protein.
Length = 518
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 328
>AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein.
Length = 518
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 328
>AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein.
Length = 396
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 328
>AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 328
>AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease
protein.
Length = 518
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 328
>AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 49.6 bits (113), Expect = 1e-05
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFVAA-KFDGILGMAFSTIAV--DHV 172
GS +GF+ D VT+ G + E F+ K++GILG+A++T+A +
Sbjct: 152 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSL 211
Query: 173 TPVFDNMVAXGLVQPVFSFY-----LNRDPGATTXXXXXXXXSDPAHYRGDLVRVPLLRD 337
FD++V + VFS L T +P+ Y+GD+ P+ +
Sbjct: 212 ETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEE 271
Query: 338 TYWEFHM-------DSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAI 493
Y++ + S+N++ + A AI D+GT+L+ P K +A+ AV ++
Sbjct: 272 WYYQIEILKLEIGGQSLNLDCREYNAD--KAIVDSGTTLLRLPQKVFDAVVEAVARASL 328
>DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 135 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 194
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 195 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 254
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 255 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 313
>BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 135 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 194
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 195 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 254
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 255 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 313
>BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 135 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 194
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 195 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 254
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 255 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 313
>AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic
proteinase Asp 2 protein.
Length = 501
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 135 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 194
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 195 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 254
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 255 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 313
>AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase
protein.
Length = 501
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 135 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 194
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 195 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 254
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 255 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 313
>AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2
protein.
Length = 501
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 135 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 194
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 195 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 254
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 255 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 313
>AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein.
Length = 488
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 122 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 181
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 182 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 241
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 242 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 300
>AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving
enzyme protein.
Length = 501
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 135 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 194
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 195 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 254
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 255 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 313
>AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant 1
protein.
Length = 396
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 30 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 89
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 90 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 149
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 150 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 208
>AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein.
Length = 532
Score = 46.4 bits (105), Expect = 1e-04
Identities = 50/179 (27%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Frame = +2
Query: 5 GSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIAV--DHV 172
G G L TD V++ G V + A++E F+ + ++GILG+A++ IA D +
Sbjct: 166 GKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSL 225
Query: 173 TPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTXXXXXXXXSDPAHYRGDLVRVPL 328
P FD++V V +FS F LN+ A+ D + Y G L P+
Sbjct: 226 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 285
Query: 329 LRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGTSLIAGPSKEVEALNAAVGATA 490
R+ Y+E + V +N C + +I D+GT+ + P K EA ++ A +
Sbjct: 286 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 344
>AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein.
Length = 1428
Score = 33.5 bits (73), Expect = 0.95
Identities = 18/61 (29%), Positives = 29/61 (47%)
Frame = -3
Query: 691 GSXAGPMGLGTSSAMKPDRHTVCPKLCHPGAXSSLPSSVKSFPGDGKGDSRQVRYEAAVH 512
G+ GP G +P+ + + P +P + ++ PGDG G SRQ + EA +
Sbjct: 17 GAVLGPEAAGPERE-EPECGSSGGGMSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIR 75
Query: 511 D 509
D
Sbjct: 76 D 76
>D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein.
Length = 1388
Score = 31.9 bits (69), Expect = 2.9
Identities = 13/36 (36%), Positives = 20/36 (55%)
Frame = -3
Query: 616 LCHPGAXSSLPSSVKSFPGDGKGDSRQVRYEAAVHD 509
+ P +P + ++ PGDG G SRQ + EA + D
Sbjct: 1 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRD 36
>AK126456-1|BAC86557.1| 199|Homo sapiens protein ( Homo sapiens
cDNA FLJ44492 fis, clone UTERU2035331. ).
Length = 199
Score = 31.9 bits (69), Expect = 2.9
Identities = 11/26 (42%), Positives = 15/26 (57%)
Frame = +1
Query: 604 PGGTISGTRCACPASWRWTCPNPWAP 681
PG ++ C CP +WR CP P +P
Sbjct: 103 PGFQLTEHGCTCPDTWRHLCPCPLSP 128
>AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving
enzyme type C protein.
Length = 457
Score = 31.9 bits (69), Expect = 2.9
Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 13/141 (9%)
Frame = +2
Query: 107 FVAAKFDGILGMAFSTIAVDHVTPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTX 262
+ K++G LG + + D + P FD++V V +FS F LN+ A+
Sbjct: 132 YTQGKWEGELG---TDLPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVG 188
Query: 263 XXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGT 427
D + Y G L P+ R+ Y+E + V +N C + +I D+GT
Sbjct: 189 GSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT 248
Query: 428 SLIAGPSKEVEALNAAVGATA 490
+ + P K EA ++ A +
Sbjct: 249 TNLRLPKKVFEAAVKSIKAAS 269
>AC099344-1|AAY14825.1| 47|Homo sapiens unknown protein.
Length = 47
Score = 31.9 bits (69), Expect = 2.9
Identities = 13/36 (36%), Positives = 20/36 (55%)
Frame = -3
Query: 616 LCHPGAXSSLPSSVKSFPGDGKGDSRQVRYEAAVHD 509
+ P +P + ++ PGDG G SRQ + EA + D
Sbjct: 1 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRD 36
>AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving
enzyme I-457 protein.
Length = 457
Score = 31.9 bits (69), Expect = 2.9
Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 13/141 (9%)
Frame = +2
Query: 107 FVAAKFDGILGMAFSTIAVDHVTPVFDNMVAXGLVQPVFS-------FYLNRDPG-ATTX 262
+ K++G LG + + D + P FD++V V +FS F LN+ A+
Sbjct: 132 YTQGKWEGELG---TDLPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVG 188
Query: 263 XXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF---CAQ--GCSAIADTGT 427
D + Y G L P+ R+ Y+E + V +N C + +I D+GT
Sbjct: 189 GSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT 248
Query: 428 SLIAGPSKEVEALNAAVGATA 490
+ + P K EA ++ A +
Sbjct: 249 TNLRLPKKVFEAAVKSIKAAS 269
>L12701-1|AAA53504.2| 333|Homo sapiens engrailed protein protein.
Length = 333
Score = 31.1 bits (67), Expect = 5.1
Identities = 12/25 (48%), Positives = 16/25 (64%)
Frame = -3
Query: 613 CHPGAXSSLPSSVKSFPGDGKGDSR 539
C PGA LP++ PGDG+G S+
Sbjct: 135 CAPGAGGPLPAAGSDSPGDGEGGSK 159
>BC104972-1|AAI04973.1| 333|Homo sapiens engrailed homeobox 2
protein.
Length = 333
Score = 31.1 bits (67), Expect = 5.1
Identities = 12/25 (48%), Positives = 16/25 (64%)
Frame = -3
Query: 613 CHPGAXSSLPSSVKSFPGDGKGDSR 539
C PGA LP++ PGDG+G S+
Sbjct: 135 CAPGAGGPLPAAGSDSPGDGEGGSK 159
>BC104970-1|AAI04971.1| 333|Homo sapiens engrailed homeobox 2
protein.
Length = 333
Score = 31.1 bits (67), Expect = 5.1
Identities = 12/25 (48%), Positives = 16/25 (64%)
Frame = -3
Query: 613 CHPGAXSSLPSSVKSFPGDGKGDSR 539
C PGA LP++ PGDG+G S+
Sbjct: 135 CAPGAGGPLPAAGSDSPGDGEGGSK 159
>AC008060-1|AAQ96875.1| 333|Homo sapiens unknown protein.
Length = 333
Score = 31.1 bits (67), Expect = 5.1
Identities = 12/25 (48%), Positives = 16/25 (64%)
Frame = -3
Query: 613 CHPGAXSSLPSSVKSFPGDGKGDSR 539
C PGA LP++ PGDG+G S+
Sbjct: 135 CAPGAGGPLPAAGSDSPGDGEGGSK 159
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 118,094,768
Number of Sequences: 237096
Number of extensions: 2658667
Number of successful extensions: 10448
Number of sequences better than 10.0: 73
Number of HSP's better than 10.0 without gapping: 9056
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 10305
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10370898348
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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